DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and Lztr1

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_006248769.1	Gene:	Lztr1 / 360745	RGDID:	1309100	Length:	862	Species:	Rattus norvegicus

Alignment Length:	356	Identity:	91/356 - (25%)
Similarity:	147/356 - (41%)	Gaps:	60/356 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GGPQRVNHAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALN------AHTMRWTLVPQQLDDAGV 67
            |||........||...:    .....:|:..::.::...||      .|  ||..:|...:..|.
  Rat     5 GGPTGPGALTGGVSSKV----APSVDFDHSCSDSVEYLTLNFGPFETVH--RWRRLPPCDEFVGA 63

  Fly    68 PLKYPLVPFQRYGHTVVAYKDRIYIWGGRNDENLCNTLYCFDPKTAQWSRPQVTGCLPGARDGHS 132
                     :|..||||||||.||::||.|.:.:.|.|..||.|...|.|...||..|..|..||
  Rat    64 ---------RRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHS 119

  Fly   133 ACVIGNSMYIFGGFVDEINEFS-----SDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQER 192
            |.|.|:||::|||:..:|...|     :|:......|.:|...:..|..|..|..|.:..| .::
  Rat   120 AVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVY-SDK 183

  Fly   193 MYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYVFGG 257
            ::||.|. |.::..:..     ..|...|.:...|.....:|::|....:..:.|....::||.|
  Rat   184 LWIFAGY-DGNARLNDM-----WTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSG 242

  Fly   258 YNGLLDQHFNDLYTFDPRTKLW------NLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPRSGS 316
            .:|.  :..|:|:.|:.:.|.|      :|:|.:...|..|.....:.....:::|||    :..
  Rat   243 QSGA--KITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGG----AAD 301

  Fly   317 SSSP-------------AAVSPT--QETGGA 332
            ::.|             ..|.|:  .|.|||
  Rat   302 NTLPNELHCYDVDFQTWEVVQPSSDSEVGGA 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	10/61 (16%)
		Kelch_6	13..60	CDD:290672	8/52 (15%)
		KELCH repeat	78..125	CDD:276965	23/46 (50%)
		Kelch_1	78..117	CDD:279660	20/38 (53%)
		KELCH repeat	128..170	CDD:276965	16/46 (35%)
		Kelch_3	137..188	CDD:290151	15/55 (27%)
		KELCH repeat	180..236	CDD:276965	11/55 (20%)
		Kelch_3	192..248	CDD:290151	9/55 (16%)
		Kelch_5	237..276	CDD:290565	9/38 (24%)
Lztr1	XP_006248769.1	KELCH repeat	65..111	CDD:276965	23/45 (51%)
		Kelch_3	74..123	CDD:290151	21/48 (44%)
		KELCH repeat	115..169	CDD:276965	17/53 (32%)
		Kelch_3	124..180	CDD:290151	15/55 (27%)
		Kelch_1	171..216	CDD:279660	10/51 (20%)
		Kelch_3	234..289	CDD:290151	13/56 (23%)
		Kelch_1	280..323	CDD:279660	6/46 (13%)
		KELCH repeat	281..323	CDD:276965	6/45 (13%)
		SPOP_C_like	571..631	CDD:269810
		BTB	662..761	CDD:279045
		BTB	665..762	CDD:197585
		SPOP_C_like	765..>800	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4693
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810