DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and Klhdc1

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_006240231.1	Gene:	Klhdc1 / 314190	RGDID:	1308211	Length:	406	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	93/355 - (26%)
Similarity:	143/355 - (40%)	Gaps:	102/355 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QRVNHAAVGVGDFIYSFGGYCTGYD---YRYNEPIDVHALNA-----HTMRWTLVPQQ------- 61
            :|..|.||..|.|:|.:|||.:..|   |..|:.|..:.:::     |.|...|.|..
  Rat    12 ERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEIWTYDVDSGLWKMHLMEGELPPSMSGSCGAC 76

  Fly    62 ----------LDDAGVPLKYPLVPFQRYGHTVV---------------------AYKDRIYIWGG 95
                      .||.|...:...|..:....|.:                     .||||:..:||
  Rat    77 INGRLYVFGGYDDKGYSNRLYFVDLRTRDGTYIWEKITKFEGQPPTPRDKLSCWVYKDRLIYFGG 141

  Fly    96 ----RNDE-NLC-----------------NTLYCFDPKTAQWSRPQVTGCL-PGARDGHSACVIG 137
                |:.| ..|                 |.::.||.||..||:|::.|.: |..|..||..|:|
  Rat   142 YGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLG 206

  Fly   138 NSMYIFGGFVDEINEFSSDVHSLNLDTMEWR-YVQTFGVPPSYRDFHASVAYEQERMYIFGGRGD 201
            |..|:|||.|  :....:|:|.|||||..|. .:...|..|.:|.:|...|...:::::|||...
  Rat   207 NKGYVFGGRV--LQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAIADDKLFLFGGLSA 269

  Fly   202 KHSPYHSQEETYCHEIVYLDMKTKVW----HRPFTAGKV----PVGRRSHSMFVYNKLIYVFGGY 258
            .:.|.   .:.:.|.|:     |..|    |.|:|..::    .:|:.:.        |.||||.
  Rat   270 DNIPL---SDGWIHNII-----TNCWKQLRHLPYTRPRLWHTACLGKENE--------IMVFGGS 318

  Fly   259 NG---LLDQ-HFNDLYTFDPRTKLWNLIRA 284
            ..   .||. |.|||..|  :|:.::|:|:
  Rat   319 KDNLLFLDTGHCNDLLIF--QTQPYSLLRS 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	21/80 (26%)
		Kelch_6	13..60	CDD:290672	17/54 (31%)
		KELCH repeat	78..125	CDD:276965	19/90 (21%)
		Kelch_1	78..117	CDD:279660	16/81 (20%)
		KELCH repeat	128..170	CDD:276965	19/42 (45%)
		Kelch_3	137..188	CDD:290151	19/51 (37%)
		KELCH repeat	180..236	CDD:276965	14/59 (24%)
		Kelch_3	192..248	CDD:290151	12/63 (19%)
		Kelch_5	237..276	CDD:290565	13/42 (31%)
Klhdc1	XP_006240231.1	PHA03098	<13..162	CDD:222983	32/148 (22%)
		KELCH repeat	13..66	CDD:276965	16/52 (31%)
		KELCH repeat	70..120	CDD:276965	5/49 (10%)
		KELCH repeat	124..194	CDD:276965	18/69 (26%)
		PLN02153	183..>323	CDD:177814	46/157 (29%)
		KELCH repeat	197..235	CDD:276965	18/39 (46%)
		KELCH repeat	248..295	CDD:276965	12/54 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920