DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and Lztr1

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001259114.1	Gene:	Lztr1 / 31037	FlyBaseID:	FBgn0040344	Length:	998	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	95/348 - (27%)
Similarity:	146/348 - (41%)	Gaps:	99/348 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 HALNAH------TMRWTLVPQQLDDAGVPLKYPLVPFQRYGHTVVAYKDRIYIWGGRNDENLCNT 104
            :|||..      |.:||.:.:..:..|.         :|..||||||||.::::||.|.:|:.|.
  Fly   223 NALNVDFTSYTATHQWTRMLECAEFVGA---------KRSKHTVVAYKDAMFVFGGDNGKNMLND 278

  Fly   105 LYCFDPKTAQWSRPQVTGCLPGARDGHSACVIGNSMYIFGGFVDEIN------------------ 151
            |..|..|...|.|...||..|..|..|||.|.|:||:||||:..:|:
  Fly   279 LIRFGVKDKSWGRACATGTPPAPRYHHSAVVAGSSMFIFGGYTGDIHSNSNLTNKNDLFEYKFQS 343

  Fly   152 ------EFS-------------------------------SDVHSLNL-DTMEWRYVQTFG-VPP 177
                  :||                               :|:.:||| ...:|..|...| .||
  Fly   344 AMWVEWKFSGRQPVPRSAHGAAVYDNKMWIYAGYDGNARLNDMWTLNLTGENQWEEVDQLGDRPP 408

  Fly   178 SYRDFHASVAYEQERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHR----PFTAG--KV 236
            :..:|..:||  ::.||:|.|:....         ..:.:.....||:.|.|    |...|  ..
  Fly   409 TCCNFPVAVA--RDAMYVFSGQSGLQ---------ITNSLFEFHFKTRTWRRISNEPVLRGATSA 462

  Fly   237 PVGRR-SHSMFVYNKLIYVFGGYNGLLDQHF-NDLYTFDPRTKLWNLIR--ANGKAPTARRRQCA 297
            |..|| .|:|..:::.:||||   |..|... |||:.:|..:::|::|:  .|...|:.|....:
  Fly   463 PPSRRYGHTMVHHDRFLYVFG---GSADSTLPNDLHCYDLDSQVWSVIQPEQNSDVPSGRVFHAS 524

  Fly   298 IVMGTRMFLFGGT---SPRSGSS 317
            .|:...|::||||   |.|.|.:
  Fly   525 AVICDAMYIFGGTVDNSVRRGDT 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	7/28 (25%)
		Kelch_6	13..60	CDD:290672	6/19 (32%)
		KELCH repeat	78..125	CDD:276965	21/46 (46%)
		Kelch_1	78..117	CDD:279660	18/38 (47%)
		KELCH repeat	128..170	CDD:276965	20/97 (21%)
		Kelch_3	137..188	CDD:290151	21/107 (20%)
		KELCH repeat	180..236	CDD:276965	13/61 (21%)
		Kelch_3	192..248	CDD:290151	15/62 (24%)
		Kelch_5	237..276	CDD:290565	15/40 (38%)
Lztr1	NP_001259114.1	PLN02153	237..554	CDD:177814	91/334 (27%)
		KELCH repeat	252..298	CDD:276965	21/45 (47%)
		Kelch_3	261..310	CDD:290151	19/48 (40%)
		Kelch_5	299..>329	CDD:290565	14/29 (48%)
		KELCH repeat	302..355	CDD:276965	15/52 (29%)
		Kelch_1	358..400	CDD:279660	5/41 (12%)
		KELCH repeat	359..407	CDD:276965	7/47 (15%)
		KELCH repeat	410..455	CDD:276965	11/55 (20%)
		Kelch_1	410..452	CDD:279660	11/52 (21%)
		Kelch_1	466..509	CDD:279660	16/45 (36%)
		KELCH repeat	467..509	CDD:276965	15/44 (34%)
		BTB	564..704	CDD:279045
		BTB	575..707	CDD:197585
		SPOP_C_like	707..766	CDD:269810
		BTB	798..898	CDD:279045
		BTB	802..902	CDD:197585
		SPOP_C_like	902..960	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9233
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.870