DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12081 and HCFC2

DIOPT Version :9

Sequence 1:NP_001259343.1 Gene:CG12081 / 31799 FlyBaseID:FBgn0030053 Length:403 Species:Drosophila melanogaster
Sequence 2:NP_037452.1 Gene:HCFC2 / 29915 HGNCID:24972 Length:792 Species:Homo sapiens


Alignment Length:263 Identity:79/263 - (30%)
Similarity:124/263 - (47%) Gaps:22/263 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 VPFQRYGHTVVAYKDRIYIWGGRNDENLCNTLYCFDPKTAQWSRPQVTGCLPGARDGHSACVIGN 138
            ||..|:||..||.::.:.|:||.| |.:.:.|:.::..|.||..|.|.|.:|.....|.....|.
Human    19 VPRARHGHRAVAIRELMIIFGGGN-EGIADELHVYNTATNQWFLPAVRGDIPPGCAAHGFVCDGT 82

  Fly   139 SMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTF----GVPPSYRDFHASVAYEQERMYIFGGR 199
            .:.:|||.| |...:|::::.|......|:.|:..    |:||..|..|:...| ..:.|:|||.
Human    83 RILVFGGMV-EYGRYSNELYELQASRWLWKKVKPHPPPSGLPPCPRLGHSFSLY-GNKCYLFGGL 145

  Fly   200 GDKHSPYHSQEETYCHEIVYLDMK----TKVWHRPFTAGKVPVGRRSHSMFVYNK------LIYV 254
            .::....::....|.::...|:::    ...|..|.|.|.||..|.||:..:|.|      .:||
Human   146 ANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVTKGVVPSPRESHTAVIYCKKDSGSPKMYV 210

  Fly   255 FGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPRSG--SS 317
            |||..|   ...:||:..|..|..|:.....|..|..|....|.|:|.:|::|||..|..|  :.
Human   211 FGGMCG---ARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTE 272

  Fly   318 SSP 320
            :||
Human   273 TSP 275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12081NP_001259343.1 KELCH repeat 13..69 CDD:276965
Kelch_6 13..60 CDD:290672
KELCH repeat 78..125 CDD:276965 17/46 (37%)
Kelch_1 78..117 CDD:279660 14/38 (37%)
KELCH repeat 128..170 CDD:276965 10/41 (24%)
Kelch_3 137..188 CDD:290151 15/54 (28%)
KELCH repeat 180..236 CDD:276965 13/59 (22%)
Kelch_3 192..248 CDD:290151 15/59 (25%)
Kelch_5 237..276 CDD:290565 15/44 (34%)
HCFC2NP_037452.1 PLN02193 <2..262 CDD:177844 73/248 (29%)
KELCH repeat 23..69 CDD:276965 17/46 (37%)
Kelch 1 34..79 14/45 (31%)
Kelch 2 83..130 13/47 (28%)
KELCH repeat 127..186 CDD:276965 13/59 (22%)
Kelch_3 136..198 CDD:290151 15/61 (25%)
KELCH repeat 190..241 CDD:276965 17/53 (32%)
Kelch 3 207..255 16/50 (32%)
Kelch_3 207..253 CDD:290151 15/48 (31%)
KELCH repeat 245..312 CDD:276965 12/31 (39%)
Kelch_3 254..323 CDD:290151 9/22 (41%)
Kelch 4 257..303 8/19 (42%)
Kelch_5 312..354 CDD:290565
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..447
FN3 <618..672 CDD:238020
FN3 678..778 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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