DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and Rabepk

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_038960698.1	Gene:	Rabepk / 296649	RGDID:	1310612	Length:	397	Species:	Rattus norvegicus

Alignment Length:	352	Identity:	93/352 - (26%)
Similarity:	143/352 - (40%)	Gaps:	75/352 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RVNHAA-----VGVGD--FIYSFGGYCTGYDYRYNEPIDVHALNAHTMRWTLVPQQLDDAGVPLK 70
            ||.|:.     ||..:  .::..||......:.     |||.::..|.||....::
  Rat    56 RVGHSCSYFPPVGEAEKGKVFIVGGANPNQSFS-----DVHTMDLGTHRWDTATRE--------- 106

  Fly    71 YPLVPFQRYGHTVV---AYKDRIYIWGGRNDENLCNTLYCFDPKTAQWSRPQVTGCLPGARDGH- 131
             .|:|  ||.|...   .....|:::||.:.....|.|...:|:...||.|:||||.|..|..|
  Rat   107 -GLLP--RYEHASFLPSCSPHSIWVFGGADQSGNRNCLQVMNPEARTWSTPEVTGCPPSPRTFHT 168

  Fly   132 SACVIGNSMYIFGGF------VDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQ 190
            |:..|||.:|:|||.      |.::.     :|..:.:|:.|...:|.|.|||.|..||.|| ..
  Rat   169 SSAAIGNHLYVFGGGERGAQPVQDVK-----LHVFDANTLTWAQPETHGSPPSPRHGHAMVA-AG 227

  Fly   191 ERMYIFGG-RGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYV 254
            .:::|.|| .||:..     ::.:|     :|:....|.:....|..|||..:|:.......:||
  Rat   228 TKLFIHGGLAGDRFF-----DDLHC-----IDIGDMSWQKLGPTGTAPVGCAAHAAVAVGHHVYV 282

  Fly   255 FGGY--NGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTAR--RRQCAI---VMGTRMFLFGGTSP 312
            |||.  .|.|    |.:|.:....:.|.:::.:...|..|  ...|.|   ||.      ...:.
  Rat   283 FGGMTATGAL----NTMYKYHTEKQHWTILQFDTSLPPGRLDHSMCVIPWPVMS------ASDTE 337

  Fly   313 RSGS-------SSSPAAVSPTQETGGA 332
            .|||       ....||..|...:||:
  Rat   338 DSGSVILSLQDEKGDAAEKPETRSGGS 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	13/62 (21%)
		Kelch_6	13..60	CDD:290672	13/53 (25%)
		KELCH repeat	78..125	CDD:276965	16/49 (33%)
		Kelch_1	78..117	CDD:279660	10/41 (24%)
		KELCH repeat	128..170	CDD:276965	14/48 (29%)
		Kelch_3	137..188	CDD:290151	19/56 (34%)
		KELCH repeat	180..236	CDD:276965	14/56 (25%)
		Kelch_3	192..248	CDD:290151	13/56 (23%)
		Kelch_5	237..276	CDD:290565	13/40 (33%)
Rabepk	XP_038960698.1	Kelch_2	55..105	CDD:400133	13/53 (25%)
		KELCH repeat	111..160	CDD:276965	15/48 (31%)
		Kelch_3	124..172	CDD:404319	17/47 (36%)
		PLN02193	<151..>319	CDD:177844	56/187 (30%)
		KELCH repeat	164..215	CDD:276965	16/55 (29%)
		KELCH repeat	218..263	CDD:276965	13/55 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920