DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and Klhdc1

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_839984.1	Gene:	Klhdc1 / 271005	MGIID:	2672853	Length:	406	Species:	Mus musculus

Alignment Length:	355	Identity:	95/355 - (26%)
Similarity:	139/355 - (39%)	Gaps:	102/355 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QRVNHAAVGVGDFIYSFGGYCTGYD---YRYNE-----PIDVHALNAHTMRWTLVPQQ------- 61
            :|..|.||..|.|:|.:|||.:..|   |..|:     .||......|.|...|.|..
Mouse    12 ERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEMWTYDIDSGLWKMHLMEGELPPSMSGSCGAC 76

  Fly    62 ----------LDDAGVPLKYPLV---------------------PFQRYGHTVVAYKDRIYIWGG 95
                      .||.|...:...|                     |..|...:...||||:..:||
Mouse    77 IHGRLYVFGGYDDKGYSNRLYFVNLRTRDGTYTWEKITKFDGQPPTPRDKLSCWVYKDRLIYFGG 141

  Fly    96 ----RNDE-NLC-----------------NTLYCFDPKTAQWSRPQVTGCL-PGARDGHSACVIG 137
                |:.| ..|                 |.::.||.||..||:|::.|.: |..|..||..|:|
Mouse   142 YGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLG 206

  Fly   138 NSMYIFGGFVDEINEFSSDVHSLNLDTMEWR-YVQTFGVPPSYRDFHASVAYEQERMYIFGGRGD 201
            |..|:|||.|  :....:|:|.|||||..|. .:...|..|.:|.:|...|...:::::|||...
Mouse   207 NKGYVFGGRV--LQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNA 269

  Fly   202 KHSPYHSQEETYCHEIVYLDMKTKVW----HRPFTAGKV----PVGRRSHSMFVYNKLIYVFGGY 258
            .:.|.   .:.:.|.|.     |..|    |.|:|..::    .:|:.:.        |.||||.
Mouse   270 DNIPL---SDGWIHNIT-----TNCWKQLRHLPYTRPRLWHTACLGKENE--------IMVFGGS 318

  Fly   259 NG---LLDQ-HFNDLYTFDPRTKLWNLIRA 284
            ..   .||. |.|||..|  :|:.::|:|:
Mouse   319 KDNLLFLDTGHCNDLLIF--QTQPYSLLRS 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	22/80 (28%)
		Kelch_6	13..60	CDD:290672	18/54 (33%)
		KELCH repeat	78..125	CDD:276965	19/69 (28%)
		Kelch_1	78..117	CDD:279660	16/60 (27%)
		KELCH repeat	128..170	CDD:276965	19/42 (45%)
		Kelch_3	137..188	CDD:290151	19/51 (37%)
		KELCH repeat	180..236	CDD:276965	14/59 (24%)
		Kelch_3	192..248	CDD:290151	12/63 (19%)
		Kelch_5	237..276	CDD:290565	13/42 (31%)
Klhdc1	NP_839984.1	KELCH repeat	13..66	CDD:276965	17/52 (33%)
		Kelch_5	13..54	CDD:290565	15/40 (38%)
		Kelch 1	24..76		14/51 (27%)
		KELCH repeat	70..120	CDD:276965	4/49 (8%)
		Kelch_3	79..124	CDD:290151	5/44 (11%)
		Kelch 2	80..134		7/53 (13%)
		Kelch 3	135..181		10/45 (22%)
		Kelch_3	<170..205	CDD:290151	13/34 (38%)
		KELCH repeat	197..245	CDD:276965	20/49 (41%)
		Kelch_3	206..256	CDD:290151	19/51 (37%)
		Kelch 4	208..258		18/51 (35%)
		Kelch_4	247..295	CDD:290154	12/55 (22%)
		KELCH repeat	248..295	CDD:276965	12/54 (22%)
		Kelch 5	260..307		11/54 (20%)
		Kelch 6	311..361		15/46 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920