DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and tea1

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_588351.1	Gene:	tea1 / 2539047	PomBaseID:	SPCC1223.06	Length:	1147	Species:	Schizosaccharomyces pombe

Alignment Length:	418	Identity:	103/418 - (24%)
Similarity:	166/418 - (39%)	Gaps:	108/418 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LWTVHL------------DGGPQRVNHAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMR 54
            ||.::|            :....|:.||::.:|:....||| .|.:|....:...::.||..::.
pombe   111 LWVLNLATSQFTSLRSLGETPSPRLGHASILIGNAFIVFGG-LTNHDVADRQDNSLYLLNTSSLV 174

  Fly    55 WTLVPQQLDDAGVPLKYPLVPFQRYGHTVVAYKDRIYIWGGRNDENLCNTLYCFD-----PKTAQ 114
            |    |:.:.:|..      |..|||||:.....:|.::|||..:...|.|.|||     ...::
pombe   175 W----QKANASGAR------PSGRYGHTISCLGSKICLFGGRLLDYYFNDLVCFDLNNLNTSDSR 229

  Fly   115 WSRPQVTGCLPGARDGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSY 179
            |....|....|.||.||.|....:.:||||| .|..| |.:|:...:.....|..|:||||.|:.
pombe   230 WELASVVNDPPPARAGHVAFTFSDKLYIFGG-TDGAN-FFNDLWCYHPKQSAWSKVETFGVAPNP 292

  Fly   180 RDFHASVAYEQERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHR----PFTAGKVPVGR 240
            |..||:...| ..:|:||||        :.:.|:.:::....:.:|.|::    |||    |..|
pombe   293 RAGHAASVVE-GILYVFGGR--------ASDGTFLNDLYAFRLSSKHWYKLSDLPFT----PSPR 344

  Fly   241 RSHSMFVYNKLIYVFGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQ---------- 295
            .||::......:.:.||..|......| :|..|  |..:.|    |..||...||
pombe   345 SSHTLSCSGLTLVLIGGKQGKGASDSN-VYMLD--TSRFRL----GSVPTTSGRQRNTSFFSNST 402

  Fly   296 --------CAIVMGTRMFLFGGTSPRS----------GSSSS---------------------PA 321
                    ..::..:|:..:.|:..||          |||:|                     |:
pombe   403 GNTNPSAFNGLLTSSRIPSYNGSKVRSTSHPSRQQYIGSSNSRFNTRHQTISTPVSGRASNDLPS 467

  Fly   322 AVSPTQETGGAAAAGGVVPPGVALIDYS 349
            .|.||:..     :..::.|...|..:|
pombe   468 PVVPTRSN-----SSSILQPSYNLNSHS 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	14/55 (25%)
		Kelch_6	13..60	CDD:290672	12/46 (26%)
		KELCH repeat	78..125	CDD:276965	16/51 (31%)
		Kelch_1	78..117	CDD:279660	15/43 (35%)
		KELCH repeat	128..170	CDD:276965	14/41 (34%)
		Kelch_3	137..188	CDD:290151	19/50 (38%)
		KELCH repeat	180..236	CDD:276965	15/59 (25%)
		Kelch_3	192..248	CDD:290151	15/59 (25%)
		Kelch_5	237..276	CDD:290565	10/38 (26%)
tea1	NP_588351.1	KELCH repeat	80..131	CDD:276965	3/19 (16%)
		Kelch_3	92..142	CDD:290151	6/30 (20%)
		KELCH repeat	134..181	CDD:276965	13/51 (25%)
		Kelch_3	143..194	CDD:290151	17/61 (28%)
		Kelch_2	187..236	CDD:284956	15/48 (31%)
		KELCH repeat	188..239	CDD:276965	16/50 (32%)
		Kelch_1	242..287	CDD:279660	17/46 (37%)
		KELCH repeat	243..290	CDD:276965	19/48 (40%)
		Kelch_4	292..338	CDD:290154	12/54 (22%)
		KELCH repeat	293..338	CDD:276965	12/53 (23%)
		SbcC	594..>1121	CDD:223496
		ATP-synt_B	<608..726	CDD:304375
		RILP-like	<866..952	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001118
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.900