DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12081 and KLHDC10

DIOPT Version :10

Sequence 1:NP_572494.1 Gene:CG12081 / 31799 FlyBaseID:FBgn0030053 Length:403 Species:Drosophila melanogaster
Sequence 2:NP_055812.1 Gene:KLHDC10 / 23008 HGNCID:22194 Length:442 Species:Homo sapiens


Alignment Length:379 Identity:91/379 - (24%)
Similarity:154/379 - (40%) Gaps:59/379 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 PQRVNHAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMRW---TLVPQQLDDAGVPLKYP 72
            |.|..|..|.....:|.||||...||.......:.:.|.....|:   |.|..|:...|      
Human    90 PARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG------ 148

  Fly    73 LVPFQRYGHTVVAYKDRIYIWGGR---------NDENLCNTLYCFDPKTAQWSRPQVTGCLPGAR 128
            .:|.:....::|.:.:.:.::||.         ||.::||..|      .:|:.....|..|...
Human   149 YMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKY------KRWALLSCRGKKPSRI 207

  Fly   129 DGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVP---PSYRDFHASVAYEQ 190
            .|.:..:|..|:|:|||....|  :|:|:|.|:|:|.||..::...:.   |..|..| .:|::.
Human   208 YGQAMAIINGSLYVFGGTTGYI--YSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRH-EIAHDG 269

  Fly   191 ERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWH----RPFTAGKVPVGRRSHSMFVYNKL 251
            :|:||.|| |...:.|.      .::|...:::|..|.    :|......|..||.||.......
Human   270 QRIYILGG-GTSWTAYS------LNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKND 327

  Fly   252 IYVFGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTR-MFLFGGTSPRSG 315
            :::.|||||  :....|::..:.:|..|  ::.....|......||.|.... |::.||.     
Human   328 VFICGGYNG--EVILGDIWKLNLQTFQW--VKLPATMPEPVYFHCAAVTPAGCMYIHGGV----- 383

  Fly   316 SSSSPAAVSPTQETGGAAAAGGVVPPGVALIDYSDLHVLDFEPTLKTLATMVVL 369
                 ..:...:.||.......|||   :|::.:...:|...|.|..|:...:|
Human   384 -----VNIHENKRTGSLFKIWLVVP---SLLELAWEKLLAAFPNLANLSRTQLL 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12081NP_572494.1 NanM 13..306 CDD:442289 77/312 (25%)
KELCH repeat 13..69 CDD:276965 16/58 (28%)
KELCH repeat 78..125 CDD:276965 10/55 (18%)
KELCH repeat 128..170 CDD:276965 16/41 (39%)
KELCH repeat 180..236 CDD:276965 14/59 (24%)
KLHDC10NP_055812.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..57
Kelch 1. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 87..154 18/69 (26%)
NanM 89..401 CDD:442289 82/346 (24%)
KELCH repeat 92..150 CDD:276965 16/63 (25%)
KELCH repeat 154..204 CDD:276965 10/55 (18%)
Kelch 2. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 155..198 9/48 (19%)
Kelch 3. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 199..260 19/62 (31%)
KELCH repeat 208..256 CDD:276965 16/49 (33%)
KELCH repeat 260..313 CDD:276965 14/60 (23%)
Kelch 4. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 261..319 16/65 (25%)
KELCH repeat 316..362 CDD:276965 12/49 (24%)
Kelch 5. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 320..364 10/47 (21%)
Kelch 6. /evidence=ECO:0000269|PubMed:39548056, ECO:0007744|PDB:9D8P 365..403 9/47 (19%)
Interaction with CUL2. /evidence=ECO:0000269|PubMed:23102700 401..442 9/32 (28%)
Blue background indicates that the domain is not in the aligned region.

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