DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and KLHDC8B

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_006713078.1	Gene:	KLHDC8B / 200942	HGNCID:	28557	Length:	371	Species:	Homo sapiens

Alignment Length:	329	Identity:	76/329 - (23%)
Similarity:	111/329 - (33%)	Gaps:	75/329 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 YPLVPFQR-YGHTVVAYKD-RIYIWGGRNDENL-CNTLYCFDPKTAQWSRPQVTGCLPGARDGHS 132
            :|.:|..| ||  .||::| .:.:.||.....| .:|....|..:..|   .....||.||.|.:
Human    14 FPPMPTCRVYG--TVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTW---LALAPLPTARAGAA 73

  Fly   133 ACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQT-----FGVPPSYR-DFHASVAYEQE 191
            |.|:|..:.:.|| |||:....:.|.:..:|...|....|     .||....| ::.........
Human    74 AVVLGKQVLVVGG-VDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERGEWPPKEGTSDG 137

  Fly   192 RMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYVF- 255
            .:|..||.|...:| .:|...|       :.:...|   .:...:|......|.|::...|||.
Human   138 MVYALGGMGPDTAP-QAQVRVY-------EPRRDCW---LSLPSMPTPCYGASTFLHGNKIYVLG 191

  Fly   256 ------GGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPRS 314
                  ||..|.|.  ......||...:.|.      :.|:...|:.          |.|.:...
Human   192 TPIPLTGGRQGKLP--VTAFEAFDLEARTWT------RHPSLPSRRA----------FAGCAMAE 238

  Fly   315 GSSSSPAAVSPTQETGGAAAAGGVVPPGVALIDYSDLHVLDFEPTLKTLATMVVLKHQLDISGLP 379
            ||..|               .||:..||.        |.....|.......|..|:|. ..:.||
Human   239 GSVFS---------------LGGLQQPGP--------HNFYSRPHFVNTVEMFDLEHG-SWTKLP 279

  Fly   380 RSFR 383
            ||.|
Human   280 RSLR 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965
		Kelch_6	13..60	CDD:290672
		KELCH repeat	78..125	CDD:276965	12/49 (24%)
		Kelch_1	78..117	CDD:279660	12/41 (29%)
		KELCH repeat	128..170	CDD:276965	13/41 (32%)
		Kelch_3	137..188	CDD:290151	13/56 (23%)
		KELCH repeat	180..236	CDD:276965	9/56 (16%)
		Kelch_3	192..248	CDD:290151	11/55 (20%)
		Kelch_5	237..276	CDD:290565	12/45 (27%)
KLHDC8B	XP_006713078.1	PRK14131	1..321	CDD:237617	76/329 (23%)
		Kelch_6	20..69	CDD:290672	14/53 (26%)
		KELCH repeat	21..65	CDD:276965	12/48 (25%)
		Kelch_1	68..114	CDD:279660	15/46 (33%)
		KELCH repeat	69..114	CDD:276965	14/45 (31%)
		KELCH repeat	117..173	CDD:276965	11/66 (17%)
		Kelch	139..184	CDD:128874	11/55 (20%)
		KELCH repeat	175..227	CDD:276965	13/59 (22%)
		Kelch	186..239	CDD:128874	14/70 (20%)
		Kelch_1	228..279	CDD:279660	15/84 (18%)
		KELCH repeat	229..279	CDD:276965	14/83 (17%)
		Kelch_6	288..336	CDD:290672
		KELCH repeat	288..334	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920