DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and F53E4.1

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001368706.1	Gene:	F53E4.1 / 180050	WormBaseID:	WBGene00009978	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	440	Identity:	177/440 - (40%)
Similarity:	251/440 - (57%)	Gaps:	56/440 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WTVHLDGGPQRVNHAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMRW-TLVPQQLDDAG 66
            |||||:|||:|||||::.||..||||||||:|......:|:|||.||....|| .:.|..:.:..
Worm    10 WTVHLEGGPRRVNHASIAVGSRIYSFGGYCSGEVTDAKDPLDVHVLNTENYRWIKMNPGYVYNNR 74

  Fly    67 VPLK-------------YPLVPFQRYGHTVVAYKDRIYIWGGRNDE-NLCNTLYCFDPKTAQWSR 117
            :..|             :..||:||||||||.|:.:.|:||||||: ..||.|:.:||:...|.:
Worm    75 IITKATIESPYSDSDKMFGAVPYQRYGHTVVEYQGKAYVWGGRNDDYGACNLLHEYDPEYNVWKK 139

  Fly   118 PQVTGCLPGARDGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDF 182
            .::.|.:|.:||||:|.|..|.|::|||:.::...||.:.:..:..|..||.:.|...||.:|||
Worm   140 VEIEGFVPPSRDGHTAVVWNNQMFVFGGYEEDAQRFSQETYVFDFATSTWREMHTKNDPPRWRDF 204

  Fly   183 H-ASVAYEQERMYIFGGR-------GDKHSPYHSQEETYCHEIVYLDMKTKVWHR---PFTAGKV 236
            | |||.  ...|||||||       ||:|. :|:..:.|...::.|::.|..|.|   |....|
Worm   205 HTASVI--DGMMYIFGGRSDESGQVGDEHL-FHTIHDQYDDTLMALNLATGAWTRTKVPENTMK- 265

  Fly   237 PVGRRSHSMFVYNKLIYVFGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMG 301
            |.||||||.:||:..:|:||||.|.::.|:|:||.|||:|.:|::|...|..|:||||.|::|..
Worm   266 PGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELYCFDPKTSMWSVISVRGTYPSARRRHCSVVSN 330

  Fly   302 TRMFLFGGTSPRSGSSSSPAAVSPTQETGGAAAAGGVVPPGVALIDYSDLHVLDFEPTLKTLATM 366
            .:::|||||.|           .|..........|.:.|.|:|  |.||||||||.|:|||||..
Worm   331 GKVYLFGGTMP-----------LPCHPLSTTNYNGMISPSGLA--DLSDLHVLDFAPSLKTLAMQ 382

  Fly   367 VVLKH-QLDISGLPRSFRSDL------QMLTQ--PNSISR---PIN-QAG 403
            .||.. ::...|:..:.:::|      :|..|  ||.:|.   |.| |||
Worm   383 SVLNELKVPSKGMFETLQNELAADIRFEMYCQVMPNVVSNGGSPRNDQAG 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	25/56 (45%)
		Kelch_6	13..60	CDD:290672	24/47 (51%)
		KELCH repeat	78..125	CDD:276965	22/47 (47%)
		Kelch_1	78..117	CDD:279660	21/39 (54%)
		KELCH repeat	128..170	CDD:276965	16/41 (39%)
		Kelch_3	137..188	CDD:290151	20/51 (39%)
		KELCH repeat	180..236	CDD:276965	24/66 (36%)
		Kelch_3	192..248	CDD:290151	25/65 (38%)
		Kelch_5	237..276	CDD:290565	22/38 (58%)
F53E4.1	NP_001368706.1	KELCH repeat	99..148	CDD:276965	22/48 (46%)
		KELCH repeat	150..192	CDD:276965	16/41 (39%)
		KELCH repeat	202..266	CDD:276965	25/67 (37%)
		KELCH repeat	269..312	CDD:276965	22/42 (52%)
		Kelch_2	19..67	CDD:400133	24/47 (51%)
		KELCH repeat	20..91	CDD:276965	26/70 (37%)
		PLN02153	79..>338	CDD:177814	105/262 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159194
Domainoid	1	1.000	46	1.000	Domainoid score	I8218
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14290
Inparanoid	1	1.050	304	1.000	Inparanoid score	I1602
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54529
OrthoDB	1	1.010	-	-		D393851at33208
OrthoFinder	1	1.000	-	-		FOG0001118
OrthoInspector	1	1.000	-	-		oto18836
orthoMCL	1	0.900	-	-		OOG6_102848
Panther	1	1.100	-	-	LDO	PTHR46461
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	1	1.000	-	-		X5342
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940