Protein Alignment CG12081 and KLHDC3

DIOPT Version :10

• Sequence 1: NP_572494.1
• Gene: CG12081 / 31799
• FlyBaseID: FBgn0030053
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_476502.1
• Gene: KLHDC3 / 116138
• HGNCID: 20704
• Length: 382
• Species: Homo sapiens
• Alignment Length: 404
• Identity: 190/404 - (47%)
• Similarity: 247/404 - (61%)
• Gaps: 37/404 - (9%)

  Fly     3 WTVHLDGGPQRVNHAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMRWTLVPQQLDDAGV 67
            |||||:|||:|||||||.||..:|||||||:|.||.....||||..||.::|||.:|
Human     4 WTVHLEGGPRRVNHAAVAVGHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLP-------- 60

  Fly    68 PLK------YPLVPFQRYGHTVVAYKDRIYIWGGRND-ENLCNTLYCFDPKTAQWSRPQVTGCLP 125
            |:|      .|:||:.||||:.|...|.:.:|||||| |..||.||.||..|.:|..|:|:|.:|
Human    61 PVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPRVSGTVP 125

  Fly   126 GARDGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQ 190
            ||||||||||:|..||||||:..:.:.||:|:|.|:..||.|..:.|.|.|..:|||| |.....
Human   126 GARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKGSPARWRDFH-SATMLG 189

  Fly   191 ERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYVF 255
            ..||:||||.|:..|:||..|.||:.|...|.:|:.|........:|.||||||.|.||..:|:|
Human   190 SHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSHSAFGYNGELYIF 254

  Fly   256 GGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPRSGSSSSP 320
            ||||..|::||:||:.|:|.:..|..|...||.|..|||||..::|.::.|||||||
Human   255 GGYNARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGGTSP-------- 311

  Fly   321 AAVSPTQETGGAAAAGGVVPPGVALIDYSDLHVLDFEPTLKTLATMVVLKHQLDISGLPRSFRSD 385
               ||.:..|..          ..|||:||||:|||.|:||||..:.|:::.||.|.||...|.:
Human   312 ---SPEEGLGDE----------FDLIDHSDLHILDFSPSLKTLCKLAVIQYNLDQSCLPHDIRWE 363

  Fly   386 LQMLTQPNSISRPI 399
            |..:|..::|||||
Human   364 LNAMTTNSNISRPI 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_572494.1	NanM	13..306	CDD:442289	143/299 (48%)
		KELCH repeat	13..69	CDD:276965	29/55 (53%)
		KELCH repeat	78..125	CDD:276965	24/47 (51%)
		KELCH repeat	128..170	CDD:276965	23/41 (56%)
		KELCH repeat	180..236	CDD:276965	22/55 (40%)
KLHDC3	NP_476502.1	NanM	14..308	CDD:442289	145/302 (48%)
		KELCH repeat	14..62	CDD:276965	29/55 (53%)
		Kelch 1	25..77		25/59 (42%)
		KELCH repeat	77..122	CDD:276965	23/44 (52%)
		Kelch 2	88..138		29/49 (59%)
		KELCH repeat	128..173	CDD:276965	23/44 (52%)
		Kelch 3	139..189		22/50 (44%)
		KELCH repeat	180..236	CDD:276965	22/56 (39%)
		Kelch 4	191..249		26/57 (46%)
		KELCH repeat	239..283	CDD:276965	23/43 (53%)
		Kelch 5	251..301		23/49 (47%)