DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12081 and RABEPK

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_005251697.1	Gene:	RABEPK / 10244	HGNCID:	16896	Length:	380	Species:	Homo sapiens

Alignment Length:	314	Identity:	89/314 - (28%)
Similarity:	134/314 - (42%)	Gaps:	53/314 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TVHLDGGPQRVNHAA---VGVGDF----IYSFGGYCTGYDYRYNEPIDVHALNAHTMRWTLVPQQ 61
            ||..|....||.|:.   ..||:.    ::..||......:.     |||.::....:|     .
Human    30 TVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFS-----DVHTMDLGKHQW-----D 84

  Fly    62 LDDAGVPLKYPLVPFQRYGHTVV---AYKDRIYIWGGRNDENLCNTLYCFDPKTAQWSRPQVTGC 123
            ||..     ..|:|  ||.|...   ...|||:::||.|.....|.|...:|:|..|:.|:||..
Human    85 LDTC-----KGLLP--RYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSP 142

  Fly   124 LPGARDGH-SACVIGNSMYIFGG---FVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHA 184
            .|..|..| |:..|||.:|:|||   ....:.:  :.:|..:.:|:.|...:|.|.|||.|..|.
Human   143 PPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQD--TKLHVFDANTLTWSQPETLGNPPSPRHGHV 205

  Fly   185 SVAYEQERMYIFGG-RGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVY 248
            .|| ...:::|.|| .||:.     .::.:|.:|  .|||   |.:....|..|.|..:||....
Human   206 MVA-AGTKLFIHGGLAGDRF-----YDDLHCIDI--SDMK---WQKLNPTGAAPAGCAAHSAVAM 259

  Fly   249 NKLIYVFGGYN--GLLDQHFNDLYTFDPRTKLWNLIRANGKAPTAR--RRQCAI 298
            .|.:|:|||..  |.||    .:|.:....:.|.|::.:...|..|  ...|.|
Human   260 GKHVYIFGGMTPAGALD----TMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCII 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	13/62 (21%)
		Kelch_6	13..60	CDD:290672	11/53 (21%)
		KELCH repeat	78..125	CDD:276965	17/49 (35%)
		Kelch_1	78..117	CDD:279660	14/41 (34%)
		KELCH repeat	128..170	CDD:276965	13/45 (29%)
		Kelch_3	137..188	CDD:290151	17/53 (32%)
		KELCH repeat	180..236	CDD:276965	16/56 (29%)
		Kelch_3	192..248	CDD:290151	16/56 (29%)
		Kelch_5	237..276	CDD:290565	13/40 (33%)
RABEPK	XP_005251697.1	KELCH repeat	39..85	CDD:276965	11/55 (20%)
		Kelch_2	39..84	CDD:284956	11/54 (20%)
		KELCH repeat	94..143	CDD:276965	17/48 (35%)
		Kelch_3	107..155	CDD:290151	18/47 (38%)
		KELCH repeat	147..197	CDD:276965	15/51 (29%)
		Kelch_3	157..209	CDD:290151	18/54 (33%)
		Kelch_1	200..243	CDD:279660	15/53 (28%)
		KELCH repeat	201..248	CDD:276965	16/57 (28%)
		Kelch_1	251..291	CDD:279660	12/43 (28%)
		KELCH repeat	251..291	CDD:276965	12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950