DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12081 and klhdc8b

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_031757044.1	Gene:	klhdc8b / 100488297	XenbaseID:	XB-GENE-950279	Length:	359	Species:	Xenopus tropicalis

Alignment Length:	328	Identity:	75/328 - (22%)
Similarity:	122/328 - (37%)	Gaps:	77/328 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IYSFGGYC--TGYDYRYNEPID-VHALNAHTMRWTLVPQQLDDAGVPLKYPLVPFQRYGHTVVAY 86
            :|..|| |  ||.      |:| |..|:..:..||::|            || |..|.|...||.
Frog    38 LYVMGG-CSKTGL------PLDAVEMLDVVSQTWTVLP------------PL-PTARAGAAAVAL 82

  Fly    87 KDRIYIWGGRNDENLC--NTLYCFDPKTAQWSRPQVTGCLPGARDGHSACVIGNSMYIFGGFVDE 149
            ..::.:.||.|.|. |  .|:..::....:|.:.. :.|.|..  |.||......:|..||...:
Frog    83 GKQLLVIGGMNSEQ-CPLATVEIYNSDEGKWEKKD-SLCQPSM--GISAIENEGKIYALGGMAAD 143

  Fly   150 --------INEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQERMYIFGGRGDKHSPY 206
                    :.|.:.|:         |..:.:...|    .:.||......::|:.|||..| .|.
Frog   144 TSPQALVRVYEPAKDI---------WLQLPSMPTP----RYGASTFLRGNKIYVLGGRQGK-LPV 194

  Fly   207 HSQEETYCHEIVYLDMKTKVWHR-PFTAGKVPVGRRSHSMFVYNKLIYVFGG------YNGLLDQ 264
            .:.|.        ||::.|.|.| |    .:|..|...|..:.:...:..||      :|.....
Frog   195 TAFEA--------LDLEMKSWTRYP----SIPSRRAFASCTMTDNCFFSLGGLQQPGPHNFYSRP 247

  Fly   265 HF-NDLYTFDPRTKLWNLIRANGKAPTARRRQCAIV---MGTRMFLFGGTSPRSGSSSSPAAVSP 325
            || :.:..||....:|.   ..|::...|.::...|   :|.|:...||...:....||....:|
Frog   248 HFVSTVEMFDSEQSIWT---KPGRSMRMREKRADFVSGYLGGRVVAAGGLGNQPSPLSSVEGYNP 309

  Fly   326 TQE 328
            .::
Frog   310 VKK 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	13/46 (28%)
		Kelch_6	13..60	CDD:290672	12/37 (32%)
		KELCH repeat	78..125	CDD:276965	12/48 (25%)
		Kelch_1	78..117	CDD:279660	11/40 (28%)
		KELCH repeat	128..170	CDD:276965	9/49 (18%)
		Kelch_3	137..188	CDD:290151	9/58 (16%)
		KELCH repeat	180..236	CDD:276965	15/56 (27%)
		Kelch_3	192..248	CDD:290151	16/56 (29%)
		Kelch_5	237..276	CDD:290565	10/45 (22%)
klhdc8b	XP_031757044.1	PHA03098	<16..208	CDD:222983	51/215 (24%)
		KELCH repeat	26..70	CDD:276965	13/50 (26%)
		KELCH repeat	122..167	CDD:276965	9/55 (16%)
		KELCH repeat	170..215	CDD:276965	15/57 (26%)
		PHA03098	<203..>342	CDD:222983	25/117 (21%)
		KELCH repeat	217..264	CDD:276965	9/46 (20%)
		KELCH repeat	276..322	CDD:276965	8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010