DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and klhdc1

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_012823418.1	Gene:	klhdc1 / 100135383	XenbaseID:	XB-GENE-991189	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	263	Identity:	79/263 - (30%)
Similarity:	122/263 - (46%)	Gaps:	29/263 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QRYGHTVVAYKDRIYIWGG-----RNDENLCN-TLYCFDPKTAQWSRPQVTGCLPGARDGHSACV 135
            :|.||....:.:.:|:|||     .|:..|.| .::.:|..:..|......|.||.:..|.....
Frog    13 ERSGHCAAMHDNYLYVWGGYVTIEENEVYLPNDEIWIYDIDSGLWRMHLTDGDLPPSMSGSCGAC 77

  Fly   136 IGNSMYIFGGFVDE--INE-FSSDVHSLNLDTMEWRYVQTF-GVPPSYRDFHASVAYEQERMYIF 196
            :....|:|||:.|:  .|: |..|:||.: ....|:::..| |..|:.||..:...|: :|:..|
Frog    78 LNGKFYVFGGYDDKGYSNQLFCLDLHSKS-GQYTWKHINNFKGQSPTARDKLSCWVYD-DRLIYF 140

  Fly   197 GGRG-DKHSPYHSQEET------------YCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVY 248
            ||.| .|||..:...:.            :.::|...|.||:.|.:||.....|..|.:||..:.
Frog   141 GGYGCRKHSELNDCFDVHDASWEGQIFWGWNNDIHVFDTKTQTWFQPFVKNSPPQARAAHSCALL 205

  Fly   249 NKLIYVFGGYNGLLDQHFNDLYTFDPRTKLWN-LIRANGKAPTARRRQCAIVMG-TRMFLFGGTS 311
            :...|||||  .:|....|||:..|..|..|: .||.|||.|:.|.......:| .::|||||.|
Frog   206 DNKGYVFGG--RVLQTRMNDLHFLDLDTWTWSGGIRINGKIPSGRSWHTLTPVGDDQLFLFGGLS 268

  Fly   312 PRS 314
            ..|
Frog   269 EES 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965
		Kelch_6	13..60	CDD:290672
		KELCH repeat	78..125	CDD:276965	13/52 (25%)
		Kelch_1	78..117	CDD:279660	12/44 (27%)
		KELCH repeat	128..170	CDD:276965	12/44 (27%)
		Kelch_3	137..188	CDD:290151	16/54 (30%)
		KELCH repeat	180..236	CDD:276965	18/68 (26%)
		Kelch_3	192..248	CDD:290151	19/68 (28%)
		Kelch_5	237..276	CDD:290565	14/38 (37%)
klhdc1	XP_012823418.1	PLN02193	<14..284	CDD:177844	79/262 (30%)
		KELCH repeat	14..66	CDD:276965	13/51 (25%)
		KELCH repeat	71..117	CDD:276965	12/46 (26%)
		KELCH repeat	197..245	CDD:276965	20/49 (41%)
		KELCH repeat	248..294	CDD:276965	9/24 (38%)
		muta_rot_YjhT	258..>322	CDD:274641	7/14 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010