DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps11 and vps11

DIOPT Version :9

Sequence 1:	NP_730776.1	Gene:	Vps11 / 317987	FlyBaseID:	FBgn0052350	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001032797.1	Gene:	vps11 / 565852	ZFINID:	ZDB-GENE-050731-5	Length:	927	Species:	Danio rerio

Alignment Length:	952	Identity:	206/952 - (21%)
Similarity:	373/952 - (39%)	Gaps:	211/952 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EWKKVDLFNIIVVPFVKIPNTAEISCYCFPESKSSTEERNIKLVICDKNRNILIYLSNWECITFK 71
            :|::...|:   ...||.|:....: :..|...|:.:.....:|:.|.:..|.....:.:..:|:
Zfish     6 QWRRFVFFD---KETVKDPSENGKN-FQLPMGISACDSGRGHIVLGDMDGQIWFLTRSLQLSSFQ 66

  Fly    72 SPSTRKAIALCSLTSNNSLATVTPDINNGIH--IDIFDLNRLTKKQAAPIIASAYTQ-PSSTPLC 133
            :...| ...|..|..:|.|.:|..| ..||:  :.:::|::  :...:|:....:.. |.:.|..
Zfish    67 AYKLR-VTHLYQLKQHNILVSVGQD-EPGINPLVKVWNLDK--RDSGSPLCTRIFPAIPGNKPTE 127

  Fly   134 LNADVIDDKLFALAIGLGNGDILLHYGKITKN-FSANIRQHTVSGNA-VNGIHFDFKTQPLDTTQ 196
            ::...:.:.|..:|||..:|.::|..|.||:: .|..:..|  .||. :.|:.|   .|....|.
Zfish   128 VSCLSVHENLNFMAIGFTDGSVVLTKGDITRDRHSKTLSLH--EGNCPITGLAF---RQAGKVTH 187

  Fly   197 IMFVTCVQGVYCFMLKEK----CIMDTKFVLDNDKGNLNYRSIMCKAGGGEINDSMLVVGRADAV 257
             :||..::.|.|:.|..|    ..:||           :..::.|.|......||..:|...|.|
Zfish   188 -LFVATLEKVQCYTLSVKEYPRVELDT-----------HGCALRCSALTDPSQDSQFIVAGDDCV 240

  Fly   258 YCYTPEGRGPCFAIEGAKECLAWVGHYLIVGVKNSN---------LKQNATT----LIVLDTENK 309
            |.|.|:.||||||.:|.|....|...||:: :.:||         .:|.:.|    |.:.|.:||
Zfish   241 YLYQPDERGPCFAFDGHKLLTHWHRGYLLL-LTHSNKSPSKSDYGSRQTSPTEKHILTIYDLDNK 304

  Fly   310 IIVFQRQFQELFYVISENNFCYIVTNSGDTDACNMLMLEKNSIDVNIRLLVEKHMYNIALRLLHR 374
            .|.:...|.::..|::|....|::|:..     .:.||::......:.:|.:|:::.:|:.|...
Zfish   305 FIAYSAVFDDVIDVLAEWGSFYVLTSDR-----TVYMLQEKDTQTKLEMLFKKNLFVMAINLAKS 364

  Fly   375 EGYTSSPETALVRFQYGNHLLQKGDFSRATQEFIKTIGFIKPYAVISKLLYSRYNTYLLNYLTEW 439
            :...:...:.:.| |||:||..|||...|.|::|:|||.::|..||.|.|.::....|..||...
Zfish   365 QHLDNDGLSEIFR-QYGDHLYVKGDHDGAIQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQAL 428

  Fly   440 KKKNESSSCHTRLIECC-------------IKRDQIE---------------------------- 463
            .:::.:::.||.|:..|             ||.::.|
Zfish   429 HRQSLANADHTTLLLNCYTKLKDSSKLEEFIKSNESEVHFDVEIAIKVLRQAGYHSHAVFLAERH 493

  Fly   464 --HE----MQQDDFKHYKSPAKIKHLATLSKMYFACTPSN----------QVPVEEEHLLHQL-L 511
              ||    :|.:|.|:|:     :.|..:.::.|....||          .||.....||.:| .
Zfish   494 MHHEWYLKIQLEDLKNYQ-----EALRYIGRLPFDQAESNMKRYGKTLMHHVPESSTILLKRLCT 553

  Fly   512 EYGPASLAVDLTTYLNNITFENVKESKNILSFCSILADHNDYCAKMLAKIIEAFPVCDEKLLFYL 576
            :|.|:..:.|     .:.....|:...|...|..:.|::.......|..:||..|...|.:...|
Zfish   554 DYHPSKDSTD-----RDSLDRPVENKANPEEFIPVFANNPRELRLFLEHMIEVDPFSPEGVYDTL 613

  Fly   577 LVFYFKLWRLD------KVTSSFVSDFIKTHSLRMDKTIIVSRLYTFFN-----------VTQRI 624
            |....:.|..:      ||........:::.:...||.:::.:::.|..           ..|.:
Zfish   614 LELRLQDWAHEQDPGKKKVLQEAALSLLRSDNTVFDKALVLCQMHNFKEGVLYLYEKGKLYQQIM 678

  Fly   625 HGHQKNTGTLHNETIDKC----------------------------IENLIKNNPDVALNENLSK 661
            |.|.:|..  :.:.::.|                            |..::|:..|    .||..
Zfish   679 HYHMQNEE--YGKVVEACKRYGDSEVCLWEQALGYFARKEENCKSYISEVLKHIDD----NNLMP 737

  Fly   662 RSFLMMLKSSCSTEEIKAIKIKPIFKDRLLRSIVDSANELKLVENFNEKIKRSRSMLSLYTNNPI 726
            ...::...:..||..:..|      ||.|:..:   ..|.:.:|....||::.|.. :.:..:.|
Zfish   738 PLLVVQTLAHNSTASLSVI------KDYLINKL---ERETQQIEEDERKIRQYREE-TAHLRSEI 792

  Fly   727 E--------FRNDKCDICREMLSMQSIYFLCQHSFHEECLNYKSTKRQEKFLCIICKTRNL---- 779
            :        |:..||.:|...|.:.|::|||.||||:.||...:....|   |..|...|.
Zfish   793 QELKTCAKIFQKTKCSMCNSPLELPSVHFLCGHSFHQHCLESFAESEAE---CPTCTPENRKVMD 854

  Fly   780 ----------LSPKHSSNFSCDSSDTIAVLAKIVSIG--NKL 809
                      |.........| |:|..:|:|.....|  |||
Zfish   855 MLRAQDQKRDLHDHFHRQLRC-SNDGFSVIADYFGRGVFNKL 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps11	NP_730776.1	zf-RING_5	732..776	CDD:291308	17/43 (40%)
vps11	NP_001032797.1	WD40	<33..>179	CDD:295369	32/151 (21%)
		WD40	128..>258	CDD:295369	42/146 (29%)
		CLH	396..519	CDD:128594	26/127 (20%)
		Clathrin	402..520	CDD:279031	22/122 (18%)
		CLH	571..717	CDD:128594	22/147 (15%)
		RING	806..845	CDD:238093	16/41 (39%)
		VPS11_C	847..892	CDD:289236	8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I4508
OMA	1	1.010	-	-		QHG54534
OrthoDB	1	1.010	-	-		D227087at33208
OrthoFinder	1	1.000	-	-		FOG0005040
OrthoInspector	1	1.000	-	-		oto40307
orthoMCL	1	0.900	-	-		OOG6_102537
Panther	1	1.100	-	-	LDO	PTHR23323
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R897
SonicParanoid	1	1.000	-	-		X3565
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.800