DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Vps11 and Vps11

DIOPT Version :9

Sequence 1:	NP_730776.1	Gene:	Vps11 / 317987	FlyBaseID:	FBgn0052350	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_001101608.2	Gene:	Vps11 / 315600	RGDID:	1308038	Length:	941	Species:	Rattus norvegicus

Alignment Length:	928	Identity:	199/928 - (21%)
Similarity:	358/928 - (38%)	Gaps:	213/928 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 CFPESKSSTEERNIKLVICDKNRNILIYLSNWECITFKSPSTR---------KAIALCSLTSNNS 89
            |.|..          :.:||..|..|::......|.|...|.:         :...|..|..:|.
  Rat    44 CLPPG----------ITVCDSGRGSLVFGDMEGQIWFLPRSLQLTGFQAYKLRVTHLYQLKQHNI 98

  Fly    90 LATVTPDINNGIH--IDIFDLNRLTKKQAAPIIASAYTQ-PSSTPLCLNADVIDDKLFALAIGLG 151
            ||:|..| ..||:  :.|::|.:  :....|:....... |.:.|..::...:.:.|..:|||..
  Rat    99 LASVGED-EEGINPLVKIWNLEK--RDGGNPLCTRILPAIPGTEPTVVSCLTVHENLNFMAIGFT 160

  Fly   152 NGDILLHYGKITKNFSANIRQHTVSGNAVNGIHFDFKTQPLDTTQIMFVTCVQGVYCFMLKEKCI 216
            :|.:.|:.|.||::..:..:........|.|:.|   .|...||. :||...:.|..:::..|
  Rat   161 DGSVTLNKGDITRDRHSKTQILHKGSYPVTGLAF---RQAGKTTH-LFVVTTENVQSYIVSGK-- 219

  Fly   217 MDTKFVLDNDKGNLNYR--SIMCKAGGGEINDSMLVVGRADAVYCYTPEGRGPCFAIEGAKECLA 279
                   |..:..|:..  .:.|.|......|...:|...:.||.|.|:.||||||.||.|....
  Rat   220 -------DYPRVELDTHGCGLRCSALSDPSQDLQFIVAGDECVYLYQPDERGPCFAFEGHKLIAH 277

  Fly   280 WVGHYLIVGVKN----------SNLKQNATTLI--VLDTENKIIVFQRQFQELFYVISENNFCYI 332
            |...||::..::          |...||:...|  :.|..||.|.:...|:::..|::|....|:
  Rat   278 WFRGYLVIVSRDRKVSPKSEFTSRDSQNSDKQILNIYDLCNKFIAYSAVFEDVVDVLAEWGSLYV 342

  Fly   333 VTNSGDTDACNMLMLEKNSIDVNIRLLVEKHMYNIALRLLHREGYTSSPETALVRFQYGNHLLQK 397
            :|..|...|     |::......:.:|.:|:::.:|:.|. :..:..|...|.:..|||:||..|
  Rat   343 LTRDGRVHA-----LQEKDTQTKLEMLFKKNLFEMAINLA-KSQHLDSDGLAQIFMQYGDHLYSK 401

  Fly   398 GDFSRATQEFIKTIGFIKPYAVISKLLYSRYNTYLLNYLTEWKKKNESSSCHTRLIECCIKRDQI 462
            |:...|.|::|:|||.::|..||.|.|.::....|..||....:::.:::.||.|:..|..:  :
  Rat   402 GNHDGAVQQYIRTIGKLEPSYVIRKFLDAQRIHNLTAYLQTLHRQSLANADHTTLLLNCYTK--L 464

  Fly   463 EHEMQQDDFKHYKSPAKIK-HLATLSKM-----YFACTPSNQVPVEEEHLLHQ---------LLE 512
            :...:.::|...||.:::. .:.|..|:     |:    |:.:.:.|.|..|:         :..
  Rat   465 KDSSKLEEFIKTKSESEVHFDVETAIKVLRQAGYY----SHALYLAENHAHHEWYLKIQLEDIKN 525

  Fly   513 YGPASLAVDLTTYLNNITFENVKESKNILSFCSILADH-------------NDYCAKMLAKIIEA 564
            |..|      ..|:..:.||..:  .|:..:..||..|             .||...:..:....
  Rat   526 YQEA------LRYIGKLPFEQAE--SNMKRYGKILMHHIPEQTTQLLKGLCTDYRPSLEGRGDRE 582

  Fly   565 FPVCDEKLLFYLLVF-------------------------YFKLWRL--------------DKVT 590
            ||.|......::.:|                         |..|..|              :|:.
  Rat   583 FPSCRANSEEFIPIFANNPRELKAFLEHMSEVQPDSPQGIYDTLLELRLQNWAHEKDPQAKEKLH 647

  Fly   591 SSFVSDFIKTHSL--RMDKTIIVSRLYTFFN-----------VTQRIHGHQKNTGTLHNETIDKC 642
            :..:| .:|:...  ..||.:::.:::.|.:           ..|.:|.|.::  ..:.:.|..|
  Rat   648 AEAIS-LLKSGRFCDVFDKALVLCQMHDFQDGVLYLYEQGKLFQQIMHYHMQH--EQYRQVIAVC 709

  Fly   643 IENLIKNNPDV---ALN--------------------ENLSKRSFLMMLKSSC--STEEIKAIKI 682
             |...:..|.:   ||:                    ||.|....|:::::..  ||..:.
  Rat   710 -ERHGEQEPSLWEQALSYFARKEEDCKEYVAAVLRHIENKSLMPPLLVVQTLAHNSTATLS---- 769

  Fly   683 KPIFKDRLLRSIVDSA-----NELKLVENFNEKIKRSRSMLSLYTNNPIEFRNDKCDICREMLSM 742
              |.:|.|::.:...:     :||: |..:.|:..|.|..:.....:|..|:..||.||...|.:
  Rat   770 --IIRDYLVQKLQKQSQQIAQDELR-VRRYREETTRIRQEIQELKASPKIFQKTKCSICNSALEL 831

  Fly   743 QSIYFLCQHSFHEECLNYKSTKRQEKFLCIICKTRNL--------------LSPKHSSNFSCDSS 793
            .|::|||.||||:.|....|....:   |..|...|.              |..:......| |:
  Rat   832 PSVHFLCGHSFHQHCFESYSESDAD---CPTCLPENRKVMDMIRAQEQKRDLHDQFQHQLKC-SN 892

  Fly   794 DTIAVLAKIVSIG--NKL 809
            |:.:|:|.....|  |||
  Rat   893 DSFSVIADYFGRGVFNKL 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps11	NP_730776.1	zf-RING_5	732..776	CDD:291308	17/43 (40%)
Vps11	NP_001101608.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4559
OMA	1	1.010	-	-		QHG54534
OrthoDB	1	1.010	-	-		D227087at33208
OrthoFinder	1	1.000	-	-		FOG0005040
OrthoInspector	1	1.000	-	-		oto96938
orthoMCL	1	0.900	-	-		OOG6_102537
Panther	1	1.100	-	-	LDO	PTHR23323
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3565
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.810