Protein Alignment Vps11 and vps-11

DIOPT Version :9

• Sequence 1: NP_730776.1
• Gene: Vps11 / 317987
• FlyBaseID: FBgn0052350
• Length: 830
• Species: Drosophila melanogaster
• Sequence 2: NP_496322.2
• Gene: vps-11 / 174661
• WormBaseID: WBGene00011067
• Length: 980
• Species: Caenorhabditis elegans
• Alignment Length: 991
• Identity: 206/991 - (20%)
• Similarity: 377/991 - (38%)
• Gaps: 248/991 - (25%)

  Fly     6 FEWKKVDLFNIIVV-----PFVKIPNTAEISCYCFPESKSSTEERNIKLVICDKNRNILIYLSN- 64
            |.|::.:.|:..||     |..|.....:::..|:..|..|        |...:.:..:..|:|
 Worm     4 FGWRRFNFFDRSVVFDKDDPKQKFMGLKDVAVDCWCSSGGS--------VYLGEAKGGVFQLTNQ 60

  Fly    65 -----WECITFKSPSTRKAIALCSL-TSNNSLATVTPD---INNGIHIDIFDLNRLTKKQ---AA 117
                 |:       :.:|::|  || :::..|.::..|   :|.  .:.|:|..|:.|..   ..
 Worm    61 FSEYYWK-------AYQKSLA--SLHSADKYLFSIGEDDETVNT--LLKIWDPERVEKNTPHVMR 114

  Fly   118 PIIASAYTQPSSTPLCLNADVIDDKLFALAIGLGNGDILLHYGKITKNFSAN-----IRQHTVSG 177
            .|..|.....||:|.|..|  :...|.::.:|..:|.:|.:.|.:..:.|.|     :|..:|..
 Worm   115 TIRMSPLNPTSSSPACSIA--VHSSLQSVVVGYTDGTVLFYQGDVLHDKSLNSRWIKVRDSSVGE 177

  Fly   178 NAVNGIHFDFKTQPLDTTQIMFVTCVQGVYCFMLKEKCIMDTKFVLDNDKGNLNYRSIMCKAGGG 242
            .:|.|:  .....|...| ::||...:.|:.::|:     :.:.|:.:.|.:.|..:..|.. ..
 Worm   178 GSVTGL--AIAVLPASKT-VVFVITQKHVHSYVLE-----NGRTVIAHKKHDANGATADCWT-FD 233

  Fly   243 EINDSMLVVGRA-----DAVYCYTPEGR--GPCFAIEGAKECLAWV--GHYLIVGVKNSNLKQN- 297
            |....::|..|.     ||..|...:|.  |.|..:....|.|..|  |.||.:..|:.:|.|.
 Worm   234 ESTGQLIVASREMLFFYDADQCIDMDGGEVGRCLQLGRGHEKLQLVASGQYLALLTKHHSLIQKE 298

  Fly   298 -----ATTLIVLDTENKIIVFQRQFQELFYVISENNFCYIVTNSGDTDACNML--MLEKNSIDVN 355
                 .|.|.|.|.:.:.:.|......|..:....:...::::.|      :|  ::||| :...
 Worm   299 RDSEFMTMLSVYDIKGQYVGFSCSLPNLCRLFIAGSTMLVLSHDG------LLSELIEKN-LATK 356

  Fly   356 IRLLVEKHMYNIALRLLHREGYTSSPETALVRFQYGNHLLQKGDFSRATQEFIKTIGFIKPYAVI 420
            :.:||:|.|:::|: |:.:...........:..:|||:|..|||:..|.|::.:|||.::|..|:
 Worm   357 LDILVKKSMFDVAV-LIAKNSRDGGDYLKGIHAKYGNYLYGKGDYENAIQQYKETIGMLEPSYVM 420

  Fly   421 SKLLYSRYNTYLLNYLT---EWKKKNESSSC-----------HTRLIECCIK-RDQIEHEMQQDD 470
            .:.|.|.....|..||.   :.|:.||..:.           ..:|:|...| .|.......:|.
 Worm   421 KRYLDSSKIKELCIYLECLHDAKRDNEHQTKILMNAYAKQGEKKKLMEFVNKITDGTRVSRMRDV 485

  Fly   471 FK-----HYKSPAKIKHLATLSKMYFACTPSNQVPVEEEHL---LHQLLEYGPASLAVDLTTYLN 527
            |:     :|.:.|.:  |||..:|:            |:.|   :|.:.:|   ::.|   ||::
 Worm   486 FEILLKWNYLAEASL--LATKFQMH------------EDALNVIIHHMHKY---TMGV---TYIS 530

  Fly   528 NITFENVKESKNILSFCSILADHNDYCAKMLAKIIEAFPVCDEKLLFYLLVFYFKLWRLD--KVT 590
            .:..|:|.|.........::...:|....:..||.|.   .|.|...::.:|...:..:|  :|.
 Worm   531 KMPIESVIEMTGKFGRDLLIHARDDLMHMLWEKIQEN---TDAKKNNFMRIFDIFMGDMDASRVF 592

  Fly   591 SSFVSDFIKTHSLRMDKTII-----VSRLYTFFNVTQRIHGHQKNTGTLHNETIDKCIENLI-KN 649
            .|::.:....|    |:.||     ..||:             |.......|.:::.|...| |.
 Worm   593 LSYIENQTNEH----DEFIIPILECQMRLF-------------KVNSDWSQERLEEDIYRFINKK 640

  Fly   650 NPDVALN-----------ENL----SKRSFLMM-------------LKSSCSTEEIKAIKIKPI- 685
            |.|.||.           |::    .|...|||             |..|||.||.:.:.:..:
 Worm   641 NEDAALQMAQLFDCTPVIEHILMRCHKSKELMMYHQKKRDLEAIIRLCQSCSKEEKRRLWLDALS 705

  Fly   686 -------FKDRLLRSIVDSANELKLVENF-----------NEKIK------------RSRSMLSL 720
                   .:|.|:  |:|...|::..|..           ||.:.            |.:.::..
 Worm   706 FIGKHATARDELI--IIDLLKEIEASEQIHPLVVLELLAKNEHLTISSVRDYIIAWLRKQQIIIE 768

  Fly   721 YTNNPIEFRN----------------------DKCDICREMLSMQSIYFLCQHSFHEECLNYKST 763
            ...|.|:..|                      .||..|...|.:.:::|||:|::|..|....:.
 Worm   769 EDRNTIKENNKAMGELDGTVESLKFNAQIMQVTKCSACDTPLQLPTVHFLCKHAYHVHCFESYNM 833

  Fly   764 KRQEKFLCIICKTRNLLSPKHSSNFS------CDSSDTIAVLAKIVSIGNKLE-TKLMIRGRQKS 821
            ...:|  |..|:|....:.....::.      .::|:.:.::|..:..|...| ||...:...|.
 Worm   834 DGSDK--CPACQTTRDTTRDEEISYHKFQKELAEASNGMELIAMYLQRGLFDEKTKKTKKSEAKK 896

  Fly   822 D-------GVTCNPFN 830
            |       ..|.|||:
 Worm   897 DPFSTGRASTTTNPFD 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vps11	NP_730776.1	zf-RING_5	732..776	CDD:291308	13/43 (30%)
vps-11	NP_496322.2	CLH	407..531	CDD:128594	32/143 (22%)
		Clathrin	413..531	CDD:279031	29/137 (21%)
		RING	802..845	CDD:238093	13/44 (30%)
		VPS11_C	840..882	CDD:289236	5/41 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	104	1.000	Inparanoid score	I3530
Isobase	1	0.950	-	0	Normalized mean entropy	S4655
OMA	1	1.010	-	-		QHG54534
OrthoDB	1	1.010	-	-		D227087at33208
OrthoFinder	1	1.000	-	-		FOG0005040
OrthoInspector	1	1.000	-	-		oto20821
orthoMCL	1	0.900	-	-		OOG6_102537
Panther	1	1.100	-	-	LDO	PTHR23323
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R897
SonicParanoid	1	1.000	-	-		X3565
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.750