DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32320 and spe-42

DIOPT Version :9

Sequence 1:	NP_001097472.3	Gene:	CG32320 / 317977	FlyBaseID:	FBgn0052320	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_872213.4	Gene:	spe-42 / 353452	WormBaseID:	WBGene00007117	Length:	774	Species:	Caenorhabditis elegans

Alignment Length:	825	Identity:	161/825 - (19%)
Similarity:	325/825 - (39%)	Gaps:	198/825 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VWDHTYRRKNAIVSSEEETDNFTGKRISYLYKNHRNFDLDRTEHGKYRDSISEGDAPIYPLNSSR 71
            :| :..||.|..|           ::..::..|.|.....:....:|.:.:.:..:.:||
Worm     6 LW-NVKRRANRAV-----------RKFQFVVNNIRREKSGQNRVLRYSERLKKWLSVLYP----- 53

  Fly    72 DPEDPEPEDDPEDRCQKSPTECRCNALLY--VIGGYIVGLLMVLIWYYRNPQEACKDLNGKWIFI 134
             |...|.:|...|...:..|......||:  ::...:.|::|..:..::..|  ..:..|..|..
Worm    54 -PWKKEKDDGIYDNLFEDGTRANSIVLLFRNILMIELFGIVMYFLLSFKYSQ--YPEFIGTSIST 115

  Fly   135 VLLSFLLIILVRRRPARCIAVLCLSSLSSNQFRIAVIALCFLLAFSGPVKNIIHNTCILANTLTC 199
            ::..||:..|:..: .....::.:..:.:.:.:..::.|...:||.||..|:|.|...:|:.:.|
Worm   116 IIHVFLIFTLIFPK-MMTYFMISIHVMLTTKIKNIILILLVTMAFEGPAMNVIGNIHQVASGVAC 179

  Fly   200 ------------EQNVLIQALMLMQRIINDPSHSVEEAFKTTLAEVSRLMNKLDKLLLNLERPIA 252
                        |.||:.:..||:.|            |:..|..||..|||:.|:||.|:..:
Worm   180 VQIDVMSSRNDVEGNVMDKGAMLVSR------------FRALLQNVSGPMNKVKKMLLVLDEKM- 231

  Fly   253 QIHATFKTCTDWLFLQKDHYDY----------KMGSPYNRCLKAGNLSIAHCK---REFGEGQKE 304
                     |.::.:.:.||..          .:.:||.:||...:.:..:||   |.||.....
Worm   232 ---------TKFVDIMRRHYRVIANLSNQCRNMLKTPYTKCLDIFDDAYFYCKGKARFFGSHGDA 287

  Fly   305 CCKLELFLWFCNSLKTYTTFFDDNIQWSQMVIKDI-----------FQRLQLCFVKIRFIFITTI 358
            |..::.....|:..|.::|   :......::.|.:           ||.::....||.::.|...
Worm   288 CEMIQKTAKICHQAKGFST---EVCSLPSIIGKGVKGAAVPFYAAYFQAIEFAVKKIFYVHIEAA 349

  Fly   359 SFDHSLKFNSTGAFSSNIDQIDE-QDVKEEFEA--------------------QRHKLHFVYLW- 401
            .:  :||     ..:..|::|.: ::::.|:::                    ::..:..|.::
Worm   350 KW--ALK-----KVNPVIEEIKKAKNIRAEYQSSDDGKPNAADDTTANLRASIKKSLMGIVNVYI 407

  Fly   402 --LNLIIFILLLTI---------IYKSLCFWFRYLTDNDFENFYITEAFEDYDDQYYQIMGLR-V 454
              :|:|.|||...|         || :|.|.:.|..::||:|.::|:.|... ||.....|.| |
Worm   408 RIINIISFILRYCIMPGLLIWPFIY-TLRFMYNYNYNDDFKNRFLTKEFTKI-DQDCAFRGARKV 470

  Fly   455 LPLSNCEDNKFVKISSMRLLAKEFDTIYRSAMFLVITGIQLLCICFVDYSLYSLLTLMSYHGHMI 519
            :||...|..::|.....::..:|...........:::.:....:|.:||.:::  ||.:.|..|.
Worm   471 MPLMANESKQYVSRGQWKMTEQERPKFRLDIFITIVSCVTPFFMCMLDYGIFT--TLSTVHTLMN 533

  Fly   520 E-DVKPPSYTKIVINGGGKIGDMLRDLVQAFEPRTFKMNT-----QRCLPIPGYPKYLRYVWILL 578
            . ::..|::.::.:.|...:.|::.:.:..|.|.|..:..     :||...|..|.|...:.:.|
Worm   534 RTNIDTPAHYELKVAGNSSMSDVMNEFLDVFSPFTKSIRDRENRWRRCFNEPNPPNYTENMVMFL 598

  Fly   579 LYLLAWFLVFWEPYGLRQRHRVMMYFYPEESRRRSHDLHDTILINRKH----------------- 626
            :::.|.||...:.|..||...:..||:|...|.|:..|::.||.:|::
Worm   599 MFIAALFLCRLKAYFGRQTLVLADYFFPNRVRIRALSLYNKILQSRRNLLTEMLGNNKKDVVGGE 663

  Fly   627 ------------FFKARCMEARLLNAFESTQEFKSCATWFNSRLNWYALTLYLNRFKHNPHCRCL 679
                        |..:.|::....:...|.||        |.|:..:....|           |:
Worm   664 DVIIRRTMQSRGFVCSDCVKCEKYDMKVSDQE--------NVRVCVHCSAFY-----------CI 709

  Fly   680 SCFTVSFIGRCCTLCNKPLNKCDNVPCGWPNCRGIYCKMCFQESN 724
            :||:|:..   |..|.:.: :|.|         ||  ::.::|||
Worm   710 NCFSVTLF---CVKCEEEM-QCIN---------GI--ELYYEESN 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32320	NP_001097472.3	DC_STAMP	430..617	CDD:285077	44/193 (23%)
spe-42	NP_872213.4	DC_STAMP	446..637	CDD:369517	44/193 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I5219
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16951
Inparanoid	1	1.050	121	1.000	Inparanoid score	I3326
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46534
OrthoDB	1	1.010	-	-		D385721at33208
OrthoFinder	1	1.000	-	-		FOG0006110
OrthoInspector	1	1.000	-	-		otm14592
orthoMCL	1	0.900	-	-		OOG6_109204
Panther	1	1.100	-	-	O	PTHR21041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3882
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980