DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32320 and DCST1

DIOPT Version :9

Sequence 1:	NP_001097472.3	Gene:	CG32320 / 317977	FlyBaseID:	FBgn0052320	Length:	767	Species:	Drosophila melanogaster
Sequence 2:	NP_689707.2	Gene:	DCST1 / 149095	HGNCID:	26539	Length:	706	Species:	Homo sapiens

Alignment Length:	739	Identity:	151/739 - (20%)
Similarity:	272/739 - (36%)	Gaps:	148/739 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 KSPTECRCNALLYVIGG---YIVGLLMVLIWYYRNPQEACKDLNGKWIFIVLLSFLLIILVRRRP 149
            :.|.|....|||...|.   ..:||..:|:    ||....::  .|.:|:..|..|..:.....|
Human    40 RQPGEFPVTALLLGAGAGGLLAIGLFQLLV----NPMNIYEE--QKIMFLYSLVGLGAMGWGTSP 98

  Fly   150 -ARCIAVLCLSSLSSNQFRIAVIALCFLLAFSGPVKNIIHNTCILANTLTCEQNVLIQALMLMQR 213
             .||.::|.:..:...:.|:.|:.......:.|||.|:.||...:..:|.|...:.|.......|
Human    99 HIRCASLLLVPKMLGKEGRLFVLGYALAAIYVGPVANLRHNLNNVIASLGCTVELQINNTRAAWR 163

  Fly   214 IINDPSH-------SVEEAFKTTLAEVSRLMNKLDKLLLNLE----------------------R 249
            |...|..       |.:|..:.....:|.....|| ..:|.|                      .
Human   164 ISTAPLRAMFKDLLSSKELLRAETRNISATFEDLD-AQVNSETGYTPEDTMDSGETAQGREARQA 227

  Fly   250 PIAQIHATFKTCTDWLFLQKDHYDYKMGSPYNRCLKAGNLSIAHCKREFGEGQKEC--------- 305
            |.:::|         |..|| .|:.|...   ||....|.:|..|:|.|....::|
Human   228 PASRLH---------LSTQK-MYELKTKL---RCSYVVNQAILSCRRWFDRKHEQCMKHIWVPLL 279

  Fly   306 ----CKLELFLWFCNSLKTYTTFFDDNIQWSQMVIKDIFQRLQLCFVKIRFIFITTISFDHSLKF 366
                |....|.:||...|....:..:.|.     ::..|.:             |..|.:.|::
Human   280 THLLCLPMKFKFFCGIAKVMEVWCRNRIP-----VEGNFGQ-------------TYDSLNQSIR- 325

  Fly   367 NSTGAFSSNIDQIDEQ----------------DVKEEFEAQRHKLHFVYLWLNLIIFILLLTIIY 415
            ...|.||:|||..:|:                :|::....|..:|.:....|::::....|.:::
Human   326 GLDGEFSANIDFKEEKQAGVLGLNTSWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLH 390

  Fly   416 KSLCFWFRYLTDNDFENFYITEAFEDYDDQYYQIMGLRVLPLSNCEDNKFVKISSMRLLAKEFDT 480
            .|..:...|..|..|:|.||:..|...||:..::....:|||...|:...:......:.|.|...
Human   391 ASFSYMDSYNHDIRFDNIYISTYFCQIDDRRKKLGKRTLLPLRKAEEKTVIFPCKPTIQASEMSN 455

  Fly   481 IYRSAMFLVITGIQLLCICFVDYSLYSLLTLMSYHGHMIEDVKPPSYTKIVINGGGKIGDMLRDL 545
            :.|..:..:...:.|:.:|.:|::|||:...:.:|..:....:.....::.:.|...:..:||..
Human   456 VVRELLETLPILLLLVVLCGLDWALYSIFDTIRHHSFLQYSFRSSHKLEVKVGGDSMLARLLRKT 520

  Fly   546 VQAFEPRT---FKMNTQRCLPIP-GYPKYLRYVW--------ILLLYLLAWFLVFWEPYGLRQRH 598
            :.|....:   .:.|...|||.| |..  .|..|        ::.|.||       :.:|.|.|.
Human   521 IGALNTSSETVMESNNMPCLPQPVGLD--ARAYWRAAVPIGLLVCLCLL-------QAFGYRLRR 576

  Fly   599 RVMMYFYPEESRRRSHDLHDTILINRKHFFKARCMEARLLNAFESTQEFKSCATWFNSRLNWYAL 663
            .:..:::|:..::|...|::.:|..|..|.|.|  .|.:|.. |..|:...           :.|
Human   577 VIAAFYFPKREKKRILFLYNDLLKKRAAFTKLR--RAAILRR-ERQQKAPR-----------HPL 627

  Fly   664 TLYLNRFKHNPHCRCLSCFTVSFIGRCCTLCNKPLNKCDNVPCGWPNCRGIYCKMCFQESNNKCV 728
            ...|:|     .|..|.    .::.|.|.:|..| ...::..|...:|..:||..|:.:...:|.
Human   628 ADILHR-----GCPLLR----RWLCRRCVVCQAP-ETPESYVCRTLDCEAVYCWSCWDDMRQRCP 682

  Fly   729 LCCLEIDDELLEPGNSSGNSEADF 752
            :|...  :||.....|..|.:..:
Human   683 VCTPR--EELSSSAFSDSNDDTAY 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32320	NP_001097472.3	DC_STAMP	430..617	CDD:285077	41/198 (21%)
DCST1	NP_689707.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..230		2/25 (8%)
		DC_STAMP	405..595	CDD:285077	41/198 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840