DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33791 and ogdha

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	XP_005172525.1	Gene:	ogdha / 564552	ZFINID:	ZDB-GENE-030131-2143	Length:	1054	Species:	Danio rerio

Alignment Length:	1107	Identity:	543/1107 - (49%)
Similarity:	717/1107 - (64%)	Gaps:	102/1107 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RLRSLARIRRSLTLGLRGTDQHVLARQALRTIQTTSQRRGVHDLDSFANGCSAAYIEGLYNKWKR 69
            |||.:...:.:..|..:|........|.||...:...      .:.|.||.|:.|:|.:|..|..
Zfish    10 RLRPITASQTAKNLSQQGPAATPRTFQPLRCFSSPVA------AEPFLNGTSSNYVEEMYYAWLE 68

  Fly    70 NPSSVDESWNELFSSNDWSSPKRSPLQVSHSRKYRRPPVERIAVKARSGERTASGGASAAPAAPP 134
            ||.||.:||:..|.:.:..:|.        ...|:.||...:::...:..::..|       |.|
Zfish    69 NPKSVHKSWDIFFRNANAGAPP--------GTAYQSPPPLGVSLAGLAQAQSLVG-------AQP 118

  Fly   135 SDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGIVGP----------------------KKRTS- 176
            :..|.::||..:|::|||||.|||..|.||||||:..                      |||.|
Zfish   119 NVEKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGIMDADLDSCVPTDIITSSDKLDLTHVKKRLSA 183

  Fly   177 --VDGTQRHAAREVLRQHFSYIFN-----------DLNTVFKLPSSTMIGGDQEFLSLKEILDRL 228
              :..::.|.|..      |.|.|           ||:.||:||::|.||||:..|.|:||:.||
Zfish   184 LTIGESEFHFAEN------SQICNWEKGFYGLEESDLDKVFRLPTTTFIGGDESALPLREIIRRL 242

  Fly   229 ERIYCGHIGVEYMQITSLTKTNWLRDRFEKPGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSE 293
            |..||.|||||:|.|..|.:..|:|.:||:||.:..:.|||:.:|.|:.|||.||.||.:|:|||
Zfish   243 EMAYCQHIGVEFMFINDLDQCQWIRQKFERPGVMQFSLEEKRTLLARMVRSTRFEEFLQRKWSSE 307

  Fly   294 KRFGLEGCDIMIPAIKEVVDRATDHGVESILIGMAHRGRLNVLANICRKPISDILSQFHG-LQAT 357
            ||||||||:.:|||:|.::|:::::||:::::||.||||||||||:.||.:..|..||.. |:|.
Zfish   308 KRFGLEGCESLIPALKTIIDKSSENGVDTVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAA 372

  Fly   358 DSGSGDVKYHLGVFQERLNRQTNRMVRITVVANPSHLEHVNPVLLGKARAEMFQRGDTCGSTVMP 422
            |.||||||||||::..|:||.|||.:.:::||||||||.||||:.||.:||.|..|||.|..||.
Zfish   373 DEGSGDVKYHLGMYHRRINRVTNRNITLSLVANPSHLEAVNPVVQGKTKAEQFYSGDTDGKRVMS 437

  Fly   423 IIIHGDASFSGQGVVYESMHLSDLPNYTTYGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNA 487
            |::||||:|:|||:|||:.||||||:|||:||:|:|:|||:|||||||.:|||.|.||||:||||
Zfish   438 ILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVANNQIGFTTDPRMARSSPYPTDVARVVNA 502

  Fly   488 PILHVNADDPEACIQCARIAIDYRTRFKKDVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKP 552
            ||.|||||||||.:....:|.::|..|.||||:|:|.||||||||.|||||||||||::|||.|.
Zfish   503 PIFHVNADDPEAVMYVCNVAAEWRATFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIKKQKG 567

  Fly   553 CLQLYADKLIKEGVVTDSEFKAMVSSYEKICEDAWAKSKTIKTIKYSSWIDSPWPGFF--EGRDR 615
            .||.||:|||.||.||..|::..::.|:||||:|.::||..|.:....|:||||||||  :|:.:
Zfish   568 VLQKYAEKLIAEGAVTRQEYEEEIAKYDKICEEAHSRSKDEKILHIKHWLDSPWPGFFTLDGQPK 632

  Fly   616 LKLCP-TGISTDTLKTIGNMFSTPPPPEHKFETHKGILRILAQRTQMVQDKVADWSLGEAFAFGS 679
            ...|| ||:..:.|..||.:.|:.|..:  |..|.|:.|||..|..|::::..||:|||..||||
Zfish   633 SISCPSTGLPEEELAQIGQVASSVPVED--FTIHGGLSRILKGRGDMIKNRTVDWALGEYMAFGS 695

  Fly   680 LLKEGIHVRLSGQDVERGTFSHRHHVLHHQSEDKVVYNSLDHLYPDQAPYSVSNSSLSECAVLGF 744
            ||||||||||||||||||||||||||||.|:.||.:...::|:.|:||||:|.||||||..||||
Zfish   696 LLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRICIPMNHMSPNQAPYTVCNSSLSEYGVLGF 760

  Fly   745 EHGYSMASPNALVMWEGQFGDFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSG 809
            |.|::||||||||:||.|||||.||||||||.||..|:.|||||:|:|:||||.||||||||||.
Zfish   761 ELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSA 825

  Fly   810 RIERFLQMSDDDPDVYPDTCDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFS 874
            |.||||||.:||||..|...| ||..|||.:.||||.|.|.|||.||.:|||:.:.||||||.|:
Zfish   826 RPERFLQMCNDDPDFNPKITD-DFDVRQLYDCNWIVVNCSNPANYFHVIRRQILLPFRKPLIVFT 889

  Fly   875 PKSLLRHPLARSPFKDFNECSCFQRIIPDKGPAGKQPDCVQKLVFCSGKVYYDLVKERDDHEQVE 939
            ||||||||.|:|.|......:.|||:|.|.||..:.|..|:::|||:||:||:|.:||.......
Zfish   890 PKSLLRHPEAKSNFDQMLPGTHFQRVITDDGPPAQNPSEVKRIVFCTGKIYYELTRERKARNMEN 954

  Fly   940 TVALVRVEQVRRLPTRHLFLFMITMIGRILQLCPFPYDLISQQLELYPKAELLWAQEEHKNMGAW 1004
            :||:.|:|                      ||.|||:||:..:.|.:|.|:|:|.||||||.|.:
Zfish   955 SVAITRIE----------------------QLSPFPFDLVRAETEKFPNADLVWCQEEHKNQGYY 997

  Fly  1005 SYVQPRFDTALLKNENESRCVSYHGRPPSASPATGNKVQHYNEYKALITSIFGELTPENKKRIED 1069
            .||:||..|.:    |.::.|.|.||.|:|:||||||..|..|.|..:.:.|      |....:|
Zfish   998 DYVKPRMRTTI----NRTKPVWYAGREPAAAPATGNKNTHLLELKRFLDTAF------NLDAFKD 1052

  Fly  1070 RI 1071
            .|
Zfish  1053 HI 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696	15/36 (42%)
		sucA	50..1057	CDD:236499	531/1046 (51%)
		TPP_E1_OGDC_like	282..544	CDD:238974	166/262 (63%)
		Transket_pyr	668..880	CDD:280874	149/211 (71%)
		OxoGdeHyase_C	887..1056	CDD:293475	64/168 (38%)
ogdha	XP_005172525.1	2-oxogl_dehyd_N	48..83	CDD:292696	15/34 (44%)
		sucA	50..1046	CDD:236499	532/1051 (51%)
		TPP_E1_OGDC_like	296..559	CDD:238974	166/262 (63%)
		Transket_pyr	681..895	CDD:280874	149/214 (70%)
		OxoGdeHyase_C	902..1045	CDD:293475	64/168 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574854
Domainoid	1	1.000	61	1.000	Domainoid score	I10424
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62893
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	O	PTHR23152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.750