DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33791 and ogdhl

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	XP_687615.2	Gene:	ogdhl / 559207	ZFINID:	ZDB-GENE-111201-4	Length:	1008	Species:	Danio rerio

Alignment Length:	1095	Identity:	552/1095 - (50%)
Similarity:	718/1095 - (65%)	Gaps:	114/1095 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNQCRLRSLARIRRSLTLGLRGTDQHVLARQALRTIQTTSQRRGVHDL----------DSFANGC 55
            |||  ||.||...||.:..:||   ||          .|.:|  |.||          .|.| .|
Zfish     1 MNQ--LRPLAGALRSSSQWMRG---HV----------GTGKR--VFDLRRNCSSGVTEPSLA-AC 47

  Fly    56 SAAYIEGLYNKWKRNPSSVDESWNELFSSNDWSSPKRS---PLQVSHSRKYRRPPVERIAVKARS 117
            |::|:..:|..|..:..:|.|||:..|.:.:.||...|   ||.              :.::.|:
Zfish    48 SSSYVVEMYYAWLEDHKNVHESWDAYFRNAEASSSVESGEKPLS--------------MLLQGRT 98

  Fly   118 GERTASGGASAAPAAPPSDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGI--------VGPKKR 174
            ..:|           |....|.::||..:..:|||||.|||..|.||||||        |.....
Zfish    99 MSQT-----------PAMSEKVVEDHLAVHTLIRAYQVRGHHVARLDPLGILTADLDSFVPSDLI 152

  Fly   175 TSVDGTQRHAAREVLRQHFSYIFNDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCGHIGVE 239
            ||:|....:...|          :||:..|:||.:|.|||::..|.|:||:.|||..||||.|||
Zfish   153 TSIDKLASYGLEE----------SDLDKSFQLPLTTFIGGNENTLPLREIIHRLETSYCGHTGVE 207

  Fly   240 YMQITSLTKTNWLRDRFEKPGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLEGCDIM 304
            :|.|.::.:..|:|.:||.||.:..:..||:.:|.||.|||.||:|||:|:|||||||||||:::
Zfish   208 FMFINNMEQCQWIRQKFETPGIMKFSAREKRTLLARLVRSTRFEDFLARKWSSEKRFGLEGCEVL 272

  Fly   305 IPAIKEVVDRATDHGVESILIGMAHRGRLNVLANICRKPISDILSQFH-GLQATDSGSGDVKYHL 368
            |||:|.::|::::.|:||:::||.||||||||||:.||.:..|..||. .|:|.|.|||||||||
Zfish   273 IPALKMIIDKSSEAGIESVIMGMPHRGRLNVLANVVRKDLDQIFCQFDPKLEAADEGSGDVKYHL 337

  Fly   369 GVFQERLNRQTNRMVRITVVANPSHLEHVNPVLLGKARAEMFQRGDTCGSTVMPIIIHGDASFSG 433
            |::.||:||:|::.:.::::|||||||.|:||:.||.:||.|.||||.|..||.|::||||:|:|
Zfish   338 GMYHERINRETDKNITLSLMANPSHLEAVDPVVQGKTKAEQFYRGDTEGRRVMSILMHGDAAFAG 402

  Fly   434 QGVVYESMHLSDLPNYTTYGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVNADDPE 498
            ||||||:.|||:||:||||||||:|.|||:|||||||.:|||.|.||||:||||||.||||||||
Zfish   403 QGVVYETFHLSELPSYTTYGTIHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPE 467

  Fly   499 ACIQCARIAIDYRTRFKKDVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYADKLIK 563
            |.:...:||.::||.|.||||||:|.|||.||||.|||||||||||::|:|.:..|:.||||||.
Zfish   468 AVMYVCKIAAEWRTTFNKDVVIDLVCYRRFGHNEMDEPMFTQPLMYKQIRKQEHVLKKYADKLIS 532

  Fly   564 EGVVTDSEFKAMVSSYEKICEDAWAKSKTIKTIKYSSWIDSPWPGFF--EGRDRLKLCP-TGIST 625
            |||||..||:..|:.|:||||:|:..||..|.:....|:|||||.||  :|..:...|| ||:|.
Zfish   533 EGVVTLQEFEEEVAKYDKICEEAYTSSKDEKILHIRHWLDSPWPDFFKPDGEPKSMSCPSTGLSE 597

  Fly   626 DTLKTIGNMFSTPPPPEHKFETHKGILRILAQRTQMVQDKVADWSLGEAFAFGSLLKEGIHVRLS 690
            :.||.||.:.|:.|..:  |..|.|:.|||..|..|:..::|||:|.|..|||||||:|||||||
Zfish   598 EVLKHIGEVASSVPLKD--FAIHSGLSRILRGRADMITKRMADWALAEYMAFGSLLKDGIHVRLS 660

  Fly   691 GQDVERGTFSHRHHVLHHQSEDKVVYNSLDHLYPDQAPYSVSNSSLSECAVLGFEHGYSMASPNA 755
            |||||||||||||||||.|..||.....::||:.:||.|:|.||||||..|||||.|::||:|||
Zfish   661 GQDVERGTFSHRHHVLHDQEVDKRFCVPMNHLWQNQALYTVCNSSLSEYGVLGFELGFAMANPNA 725

  Fly   756 LVMWEGQFGDFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIERFLQMSDD 820
            ||.||.|||||.||||||||.||::|:.||||.:|:|:||||.||||||||||.|.|||||||.|
Zfish   726 LVCWEAQFGDFHNTAQCIIDQFISAGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSKD 790

  Fly   821 DPDVYPDTCDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFSPKSLLRHPLAR 885
            |||.||: ...||..:||.:.||||.|.||||:.||.||||:.:.||||||.|:||||||.|.||
Zfish   791 DPDRYPE-YTGDFEVQQLYDCNWIVVNCSTPASYFHVLRRQILLPFRKPLIIFTPKSLLRLPEAR 854

  Fly   886 SPFKDFNECSCFQRIIPDKGPAGKQPDCVQKLVFCSGKVYYDLVKERDDHEQVETVALVRVEQVR 950
            |.|.:....:.|.|:|||.|||.|.|:.|::::||:|||||:|.|||...:..|.||:||:||:
Zfish   855 SSFDEMVTGTKFIRVIPDDGPASKNPEKVKRVIFCTGKVYYELAKERKQLKLEENVAIVRLEQI- 918

  Fly   951 RLPTRHLFLFMITMIGRILQLCPFPYDLISQQLELYPKAELLWAQEEHKNMGAWSYVQPRFDTAL 1015
                                 .|||:|||..::|.|..|||:|.||||||||.:.|::|||.|..
Zfish   919 ---------------------SPFPFDLIKAEVEKYSNAELIWCQEEHKNMGYYDYIRPRFLTVQ 962

  Fly  1016 LKNENESRCVSYHGRPPSASPATGNKVQHYNEYKALITSIFGELTPENKKRIEDR 1070
            .||.     :.|.||.|:|:||||||..|..|.|..:.:.|      |.:..:|:
Zfish   963 PKNP-----IWYVGRDPAAAPATGNKFTHLAELKRFLDTAF------NLEAFQDK 1006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696	12/36 (33%)
		sucA	50..1057	CDD:236499	531/1021 (52%)
		TPP_E1_OGDC_like	282..544	CDD:238974	170/262 (65%)
		Transket_pyr	668..880	CDD:280874	145/211 (69%)
		OxoGdeHyase_C	887..1056	CDD:293475	71/168 (42%)
ogdhl	XP_687615.2	sucA	44..999	CDD:236499	531/1026 (52%)
		2-oxogl_dehyd_N	44..78	CDD:292696	11/34 (32%)
		TPP_E1_OGDC_like	250..513	CDD:238974	170/262 (65%)
		Transket_pyr	635..849	CDD:280874	146/214 (68%)
		OxoGdeHyase_C	856..998	CDD:293475	71/168 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574856
Domainoid	1	1.000	61	1.000	Domainoid score	I10424
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62893
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	O	PTHR23152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.710