DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33791 and OGDHL

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	NP_001334748.1	Gene:	OGDHL / 55753	HGNCID:	25590	Length:	1010	Species:	Homo sapiens

Alignment Length:	1071	Identity:	546/1071 - (50%)
Similarity:	700/1071 - (65%)	Gaps:	107/1071 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LARQALRTIQTTSQRRGVHDLDSFA----------------NGCSAAYIEGLYNKWKRNPSSVDE 76
            |..||.|.:       ..||:..|.                .|..::|:|.:|..|..||.||.:
Human    11 LGVQAARLL-------AAHDVPVFGWRSRSSGPPATFPSSKGGGGSSYMEEMYFAWLENPQSVHK 68

  Fly    77 SWNELF--SSNDWSSPKRSPLQVSHSRKYRRPP----VERIAVKARSGERTASGGASAAPAAPPS 135
            ||:..|  :|.:..|....|          |||    ..|.||.:|:  :|:
Human    69 SWDSFFREASEEAFSGSAQP----------RPPSVVHESRSAVSSRT--KTS------------- 108

  Fly   136 DWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGI--------VGPKKRTSVDGTQRHAAREVLRQH 192
              |.::||..:|::|||||.|||..|.||||||        |.....|::|....:..:|.
Human   109 --KLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEA---- 167

  Fly   193 FSYIFNDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCGHIGVEYMQITSLTKTNWLRDRFE 257
                  ||:..|:||::|.|||.:..|||:||:.|||..||.|||:|:|.|..:.:..|:|.:||
Human   168 ------DLDKEFQLPTTTFIGGSENTLSLREIIRRLENTYCQHIGLEFMFINDVEQCQWIRQKFE 226

  Fly   258 KPGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLEGCDIMIPAIKEVVDRATDHGVES 322
            .||.:..:.|||:.:|.||.||..||:|||:|:|||||||||||::||||:|.::|::::.|:|:
Human   227 TPGVMQFSSEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGIEN 291

  Fly   323 ILIGMAHRGRLNVLANICRKPISDILSQFH-GLQATDSGSGDVKYHLGVFQERLNRQTNRMVRIT 386
            :::||.||||||||||:.||.:..|..||. .|:|.|.||||||||||::.||:||.|||.:.::
Human   292 VILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLS 356

  Fly   387 VVANPSHLEHVNPVLLGKARAEMFQRGDTCGSTVMPIIIHGDASFSGQGVVYESMHLSDLPNYTT 451
            :||||||||.|:||:.||.:||.|.|||..|..||.|::||||:|:|||||||:.||||||:|||
Human   357 LVANPSHLEAVDPVVQGKTKAEQFYRGDAQGKKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTT 421

  Fly   452 YGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVNADDPEACIQCARIAIDYRTRFKK 516
            .||:|:|.|||:|||||||.:|||.|.||||:||||||.|||||||||.|....:|.::|..|.|
Human   422 NGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNK 486

  Fly   517 DVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYADKLIKEGVVTDSEFKAMVSSYEK 581
            |||:|:|.|||.||||.|||||||||||::|.:..|.|:.||||||.||.||..||:..::.|::
Human   487 DVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHRQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDR 551

  Fly   582 ICEDAWAKSKTIKTIKYSSWIDSPWPGFF--EGRDRLKLCP-TGISTDTLKTIGNMFSTPPPPEH 643
            |||:|:.:||..|.:....|:||||||||  :|..:...|| |||..|.|..||::.|:.|..:
Human   552 ICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTCPATGIPEDMLTHIGSVASSVPLED- 615

  Fly   644 KFETHKGILRILAQRTQMVQDKVADWSLGEAFAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHH 708
             |:.|.|:.|||..|..|.:::..||:|.|..||||||||||||||||||||||||||||||||.
Human   616 -FKIHTGLSRILRGRADMTKNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHD 679

  Fly   709 QSEDKVVYNSLDHLYPDQAPYSVSNSSLSECAVLGFEHGYSMASPNALVMWEGQFGDFCNTAQCI 773
            |..|:.....::||:||||||:|.||||||..|||||.||:||||||||:||.|||||.||||||
Human   680 QEVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCI 744

  Fly   774 IDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIERFLQMSDDDPDVYPDTCDADFVARQL 838
            ||.||::|:.||||.:|:|:||||.||||||||||.|.|||||||:||.|.|| ....||...||
Human   745 IDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYP-AFTKDFEVSQL 808

  Fly   839 MNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFSPKSLLRHPLARSPFKDFNECSCFQRIIPD 903
            .:.||||.|.|||||.||.||||:.:.||||||.|:||||||||.|:|.|......:.|||:||:
Human   809 YDCNWIVVNCSTPANYFHVLRRQILLPFRKPLIIFTPKSLLRHPEAKSSFDQMVSGTSFQRVIPE 873

  Fly   904 KGPAGKQPDCVQKLVFCSGKVYYDLVKERDDHEQVETVALVRVEQVRRLPTRHLFLFMITMIGRI 968
            .|.|.:.|:.||:|:||:|||||||||||...:..|.||:.|:||:
Human   874 DGAAARAPEQVQRLIFCTGKVYYDLVKERSSQDLEEKVAITRLEQI------------------- 919

  Fly   969 LQLCPFPYDLISQQLELYPKAELLWAQEEHKNMGAWSYVQPRFDTALLKNENESRCVSYHGRPPS 1033
               .|||:|||.|:.|.||.|||.|.||||||||.:.|:.|||.|.|    ..:|.:.|.||.|:
Human   920 ---SPFPFDLIKQEAEKYPGAELAWCQEEHKNMGYYDYISPRFMTIL----RRARPIWYVGRDPA 977

  Fly  1034 ASPATGNKVQHYNEYKALITSIFGELTPENK 1064
            |:|||||:..|....|..:.:.|.....|.|
Human   978 AAPATGNRNTHLVSLKKFLDTAFNLQAFEGK 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696	14/54 (26%)
		sucA	50..1057	CDD:236499	537/1040 (52%)
		TPP_E1_OGDC_like	282..544	CDD:238974	169/262 (65%)
		Transket_pyr	668..880	CDD:280874	150/211 (71%)
		OxoGdeHyase_C	887..1056	CDD:293475	72/168 (43%)
OGDHL	NP_001334748.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..100		6/28 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141948
Domainoid	1	1.000	58	1.000	Domainoid score	I10778
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62893
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	O	PTHR23152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.710