DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33791 and DHTKD1

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	NP_061176.4	Gene:	DHTKD1 / 55526	HGNCID:	23537	Length:	919	Species:	Homo sapiens

Alignment Length:	950	Identity:	356/950 - (37%)
Similarity:	510/950 - (53%)	Gaps:	107/950 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 PPSDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGIVGPKKRTSVDGTQRHAAREVLRQHFSYIF 197
            ||.|       |.:..::..|...||.||.::|| ..|.....:|...|  |..:.|:..|.
Human    50 PPVD-------HGLARLVTVYCEHGHKAAKINPL-FTGQALLENVPEIQ--ALVQTLQGPFH--- 101

  Fly   198 NDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCGHIGVEYMQITSLTKTNWLRDRFEKPGGL 262
                      ::.::...:|..||:|:|..|.:||||.|.:|..|:.|..:.:|...|||:....
Human   102 ----------TAGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKE 156

  Fly   263 DLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLEGCDIMIPAIKEVVDRATDHGVESILIGM 327
            ..|.||:|.:.:.:..|..|::|||.|||:.||:|.||.:.|:....|::..:...|:..::|||
Human   157 TFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGM 221

  Fly   328 AHRGRLNVLANICRKPISDILSQFHGLQ---ATDSGSGDVKYHLGVFQERLNRQTNRMVRITVVA 389
            .||||||:|..:.:.|...:..:..||.   ...|.:|||..|| .....|....:..:.:|::.
Human   222 PHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHL-TSSVDLYFGAHHPLHVTMLP 285

  Fly   390 NPSHLEHVNPVLLGKARAEMFQRGD---------TCGSTVMPIIIHGDASFSGQGVVYESMHLSD 445
            ||||||.||||.:||.|.....|.|         ..|..|:.:.:||||||.|||:|.|:..||:
Human   286 NPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSN 350

  Fly   446 LPNYTTYGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVNADDPEACIQCARIAIDY 510
            ||::...|::|::.|||:|:||.....|||.||:|:.|:|...|:|||.|.||..::..|:|.:|
Human   351 LPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEY 415

  Fly   511 RTRFKKDVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYADKLIKEGVVTDSEFKAM 575
            :.:|:|||:||::.||:.||||.|||.:|.|:||:.|:..|.....||:.||..|::|..|...:
Human   416 QRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEI 480

  Fly   576 VSSYEKICED-----AWAKSKTIKTIKYSSWIDSPWPGFFEGRDRLKLCPTGISTDTLKTIGNMF 635
            .|||.....|     |..:...:.       :.:.|.|..:...::....||:..|.|:.:| |.
Human   481 KSSYYAKLNDHLNNMAHYRPPALN-------LQAHWQGLAQPEAQITTWSTGVPLDLLRFVG-MK 537

  Fly   636 STPPPPEHKFETHKGILRILAQRTQMVQDKVADWSLGEAFAFGSLLKEGIHVRLSGQDVERGTFS 700
            |...|.|.:..:|.....:.::..:|:.....||:..||.|.||||.:|.:||||||||.|||||
Human   538 SVEVPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFS 602

  Fly   701 HRHHVLHHQSEDKVVYNSLDHLYPDQAPY-SVSNSSLSECAVLGFEHGYSMASPNALVMWEGQFG 764
            .||.::..|..|. .|..|:|:.|:|..: .||||.|||.||||||:|.|:.||..|.:||.|||
Human   603 QRHAIVVCQETDD-TYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFG 666

  Fly   765 DFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIERFLQMSDD-DPDVYPDT 828
            ||.|.||.|.||||:.||.||:.|||:|:||||..:|.||:|||.||||||||.|. :..|..||
Human   667 DFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDT 731

  Fly   829 CDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFSPKSLLRHPLARSPFKDFNE 893
                        ||..|.:.:|||..||.||||:...||||||..|||.|||.|.|.|..::...
Human   732 ------------VNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAP 784

  Fly   894 CSCFQRIIPDKGPAGKQPDCVQKLVFCSGKVYYDLVKERDD-----HEQVETVALVRVEQVRRLP 953
            .:.|..:|   |.:...|..|:.|||||||.:|.|||:|:.     |:    .|::|||
Human   785 GTTFNPVI---GDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHD----FAIIRVE------ 836

  Fly   954 TRHLFLFMITMIGRILQLCPFPYDLISQQLELYPKA-ELLWAQEEHKNMGAWSYVQPRFDTALLK 1017
                            :|||||.|.:.|::..|... :.:|:|||.:|||.||:|.|||
Human   837 ----------------ELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRF------ 879

  Fly  1018 NENESRC-VSYHGRPPSASPATGNKVQHYNEYKALITSIF 1056
             |.:..| :...||||...||.|....|.::::.::...|
Human   880 -EKQLACKLRLVGRPPLPVPAVGIGTVHLHQHEDILAKTF 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696
		sucA	50..1057	CDD:236499	355/949 (37%)
		TPP_E1_OGDC_like	282..544	CDD:238974	111/273 (41%)
		Transket_pyr	668..880	CDD:280874	117/213 (55%)
		OxoGdeHyase_C	887..1056	CDD:293475	53/175 (30%)
DHTKD1	NP_061176.4	OxoGdeHyase_C	58..919	CDD:330401	351/934 (38%)
DHTKD1	NP_061176.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..320		5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710