DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33791 and OGDH

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	XP_005249816.1	Gene:	OGDH / 4967	HGNCID:	8124	Length:	1038	Species:	Homo sapiens

Alignment Length:	1086	Identity:	547/1086 - (50%)
Similarity:	722/1086 - (66%)	Gaps:	95/1086 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LRSLARIRRSLTLGLRGTDQHVLARQALRTIQTTSQRRGVH--------------DLDSFANGCS 56
            ||:.|...|.||              |.:|::|.||.|...              ..:.|.:|.|
Human     4 LRTCAAKLRPLT--------------ASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTS 54

  Fly    57 AAYIEGLYNKWKRNPSSVDESWNELFSSNDWSSPK----RSPLQVSHSRKYRRPPVERIAVKARS 117
            :.|:|.:|..|..||.||.:||:..|.:.:..:|.    :|||.:|.
Human    55 SNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSR------------------ 101

  Fly   118 GERTASGGASAAPAAPPSDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGIVGPKKRTSV----- 177
            |...|...|.:...|.|:..|.::||..:|::|||||.|||..|.||||||:.....:||
Human   102 GSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADII 166

  Fly   178 ---DGTQRHAAREVLRQ-----HFSYIFNDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCG 234
               |.......:|.||.     .:....:||:.||.||::|.|||.:..|.|:||:.|||..||.
Human   167 SSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQ 231

  Fly   235 HIGVEYMQITSLTKTNWLRDRFEKPGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLE 299
            |||||:|.|..|.:..|:|.:||.||.:..|.|||:.:|.||.|||.||.||.:|:|||||||||
Human   232 HIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLE 296

  Fly   300 GCDIMIPAIKEVVDRATDHGVESILIGMAHRGRLNVLANICRKPISDILSQFHG-LQATDSGSGD 363
            ||:::|||:|.::|:::::||:.:::||.||||||||||:.||.:..|..||.. |:|.|.||||
Human   297 GCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGD 361

  Fly   364 VKYHLGVFQERLNRQTNRMVRITVVANPSHLEHVNPVLLGKARAEMFQRGDTCGSTVMPIIIHGD 428
            ||||||::..|:||.|:|.:.:::||||||||..:||::||.:||.|..|||.|..||.|::|||
Human   362 VKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGD 426

  Fly   429 ASFSGQGVVYESMHLSDLPNYTTYGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVN 493
            |:|:|||:|||:.||||||:|||:||:|:|.|||:|||||||.:|||.|.||||:||||||.|||
Human   427 AAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVN 491

  Fly   494 ADDPEACIQCARIAIDYRTRFKKDVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYA 558
            :|||||.:...::|.::|:.|.||||:|:|.||||||||.|||||||||||::|:|.||.||.||
Human   492 SDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYA 556

  Fly   559 DKLIKEGVVTDSEFKAMVSSYEKICEDAWAKSKTIKTIKYSSWIDSPWPGFF--EGRDRLKLCP- 620
            :.|:.:|||...|::..:|.|:||||:|:|:||..|.:....|:||||||||  :|:.|...||
Human   557 ELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMSCPS 621

  Fly   621 TGISTDTLKTIGNMFSTPPPPEHKFETHKGILRILAQRTQMVQDKVADWSLGEAFAFGSLLKEGI 685
            ||::.|.|..|||:.|:  .|...|..|.|:.|||..|.:||:::..||:|.|..||||||||||
Human   622 TGLTEDILTHIGNVASS--VPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMAFGSLLKEGI 684

  Fly   686 HVRLSGQDVERGTFSHRHHVLHHQSEDKVVYNSLDHLYPDQAPYSVSNSSLSECAVLGFEHGYSM 750
            |:||||||||||||||||||||.|:.||.....::||:|:||||:|.||||||..|||||.|::|
Human   685 HIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAM 749

  Fly   751 ASPNALVMWEGQFGDFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIERFL 815
            |||||||:||.|||||.||||||||.||..|:.|||||:|:|:||||.||||||||||.|.||||
Human   750 ASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFL 814

  Fly   816 QMSDDDPDVYPDTCDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFSPKSLLR 880
            ||.:|||||.||..:|:|...||.:.||:|.|.|||.|.||.||||:.:.||||||.|:||||||
Human   815 QMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLR 879

  Fly   881 HPLARSPFKDFNECSCFQRIIPDKGPAGKQPDCVQKLVFCSGKVYYDLVKERDDHEQVETVALVR 945
            ||.|||.|.:....:.|||:||:.|||.:.|:.|::|:||:|||||||.:||...:.|..||:.|
Human   880 HPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITR 944

  Fly   946 VEQVRRLPTRHLFLFMITMIGRILQLCPFPYDLISQQLELYPKAELLWAQEEHKNMGAWSYVQPR 1010
            :|                      ||.|||:||:.::::.||.|||.|.||||||.|.:.||:||
Human   945 IE----------------------QLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYYDYVKPR 987

  Fly  1011 FDTALLKNENESRCVSYHGRPPSASPATGNKVQHYNEYKALITSIF 1056
            ..|.:    :.::.|.|.||.|:|:||||||..|..|.:.|:.:.|
Human   988 LRTTI----SRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAF 1029

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696	14/36 (39%)
		sucA	50..1057	CDD:236499	535/1028 (52%)
		TPP_E1_OGDC_like	282..544	CDD:238974	162/262 (62%)
		Transket_pyr	668..880	CDD:280874	148/211 (70%)
		OxoGdeHyase_C	887..1056	CDD:293475	68/168 (40%)
OGDH	XP_005249816.1	sucA	49..1030	CDD:236499	535/1027 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141946
Domainoid	1	1.000	58	1.000	Domainoid score	I10778
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62893
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	O	PTHR23152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.710