Protein Alignment CG33791 and OGDH

DIOPT Version :10

• Sequence 1: NP_001027100.1
• Gene: CG33791 / 317974
• FlyBaseID: FBgn0035240
• Length: 1282
• Species: Drosophila melanogaster
• Sequence 2: NP_001425936.1
• Gene: OGDH / 4967
• HGNCID: 8124
• Length: 1038
• Species: Homo sapiens
• Alignment Length: 1086
• Identity: 547/1086 - (50%)
• Similarity: 722/1086 - (66%)
• Gaps: 95/1086 - (8%)

  Fly     6 LRSLARIRRSLTLGLRGTDQHVLARQALRTIQTTSQRRGVH--------------DLDSFANGCS 56
            ||:.|...|.||              |.:|::|.||.|...              ..:.|.:|.|
Human     4 LRTCAAKLRPLT--------------ASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTS 54

  Fly    57 AAYIEGLYNKWKRNPSSVDESWNELFSSNDWSSPK----RSPLQVSHSRKYRRPPVERIAVKARS 117
            :.|:|.:|..|..||.||.:||:..|.:.:..:|.    :|||.:|.
Human    55 SNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSR------------------ 101

  Fly   118 GERTASGGASAAPAAPPSDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGIVGPKKRTSV----- 177
            |...|...|.:...|.|:..|.::||..:|::|||||.|||..|.||||||:.....:||
Human   102 GSLAAVAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADII 166

  Fly   178 ---DGTQRHAAREVLRQ-----HFSYIFNDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCG 234
               |.......:|.||.     .:....:||:.||.||::|.|||.:..|.|:||:.|||..||.
Human   167 SSTDKLDLAVFKERLRMLTVGGFYGLDESDLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQ 231

  Fly   235 HIGVEYMQITSLTKTNWLRDRFEKPGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLE 299
            |||||:|.|..|.:..|:|.:||.||.:..|.|||:.:|.||.|||.||.||.:|:|||||||||
Human   232 HIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLE 296

  Fly   300 GCDIMIPAIKEVVDRATDHGVESILIGMAHRGRLNVLANICRKPISDILSQFHG-LQATDSGSGD 363
            ||:::|||:|.::|:::::||:.:::||.||||||||||:.||.:..|..||.. |:|.|.||||
Human   297 GCEVLIPALKTIIDKSSENGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGD 361

  Fly   364 VKYHLGVFQERLNRQTNRMVRITVVANPSHLEHVNPVLLGKARAEMFQRGDTCGSTVMPIIIHGD 428
            ||||||::..|:||.|:|.:.:::||||||||..:||::||.:||.|..|||.|..||.|::|||
Human   362 VKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGD 426

  Fly   429 ASFSGQGVVYESMHLSDLPNYTTYGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVN 493
            |:|:|||:|||:.||||||:|||:||:|:|.|||:|||||||.:|||.|.||||:||||||.|||
Human   427 AAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVN 491

  Fly   494 ADDPEACIQCARIAIDYRTRFKKDVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYA 558
            :|||||.:...::|.::|:.|.||||:|:|.||||||||.|||||||||||::|:|.||.||.||
Human   492 SDDPEAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYA 556

  Fly   559 DKLIKEGVVTDSEFKAMVSSYEKICEDAWAKSKTIKTIKYSSWIDSPWPGFF--EGRDRLKLCP- 620
            :.|:.:|||...|::..:|.|:||||:|:|:||..|.:....|:||||||||  :|:.|...||
Human   557 ELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPRSMSCPS 621

  Fly   621 TGISTDTLKTIGNMFSTPPPPEHKFETHKGILRILAQRTQMVQDKVADWSLGEAFAFGSLLKEGI 685
            ||::.|.|..|||:.|:  .|...|..|.|:.|||..|.:||:::..||:|.|..||||||||||
Human   622 TGLTEDILTHIGNVASS--VPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMAFGSLLKEGI 684

  Fly   686 HVRLSGQDVERGTFSHRHHVLHHQSEDKVVYNSLDHLYPDQAPYSVSNSSLSECAVLGFEHGYSM 750
            |:||||||||||||||||||||.|:.||.....::||:|:||||:|.||||||..|||||.|::|
Human   685 HIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAM 749

  Fly   751 ASPNALVMWEGQFGDFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIERFL 815
            |||||||:||.|||||.||||||||.||..|:.|||||:|:|:||||.||||||||||.|.||||
Human   750 ASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFL 814

  Fly   816 QMSDDDPDVYPDTCDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFSPKSLLR 880
            ||.:|||||.||..:|:|...||.:.||:|.|.|||.|.||.||||:.:.||||||.|:||||||
Human   815 QMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFHVLRRQILLPFRKPLIIFTPKSLLR 879

  Fly   881 HPLARSPFKDFNECSCFQRIIPDKGPAGKQPDCVQKLVFCSGKVYYDLVKERDDHEQVETVALVR 945
            ||.|||.|.:....:.|||:||:.|||.:.|:.|::|:||:|||||||.:||...:.|..||:.|
Human   880 HPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKRLLFCTGKVYYDLTRERKARDMVGQVAITR 944

  Fly   946 VEQVRRLPTRHLFLFMITMIGRILQLCPFPYDLISQQLELYPKAELLWAQEEHKNMGAWSYVQPR 1010
            :|                      ||.|||:||:.::::.||.|||.|.||||||.|.:.||:||
Human   945 IE----------------------QLSPFPFDLLLKEVQKYPNAELAWCQEEHKNQGYYDYVKPR 987

  Fly  1011 FDTALLKNENESRCVSYHGRPPSASPATGNKVQHYNEYKALITSIF 1056
            ..|.:    :.::.|.|.||.|:|:||||||..|..|.:.|:.:.|
Human   988 LRTTI----SRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAF 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	SucA	47..1057	CDD:440333	535/1031 (52%)
		PHA03307	1078..>1280	CDD:223039
OGDH	NP_001425936.1	None