DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33791 and Ogdhl

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	NP_001382038.1	Gene:	Ogdhl / 290566	RGDID:	1310916	Length:	1010	Species:	Rattus norvegicus

Alignment Length:	1091	Identity:	552/1091 - (50%)
Similarity:	708/1091 - (64%)	Gaps:	104/1091 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNQCRL---------RSLARIRRSLTLGLRGTDQHVLARQALRTIQTTSQRRGVHDLDSFANGCS 56
            |:|.||         |.|...|.....|.|        |::.....|..:.||         |.|
  Rat     1 MSQLRLLLFRLGPQARKLLATRDIAAFGGR--------RRSSGPPTTIPRSRG---------GVS 48

  Fly    57 AAYIEGLYNKWKRNPSSVDESWNELFSSNDWSSPKRSPLQVSHSRKYRRPPVERIAVKARSGERT 121
            .:|:|.:|..|..||.||.:||:..|        :|:..:.|......:||.  :..::|
  Rat    49 PSYVEEMYFAWLENPQSVHKSWDNFF--------QRATKEASVGPAQPQPPA--VIQESR----- 98

  Fly   122 ASGGASAAPAAPPSDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGI--------VGPKKRTSVD 178
                ||.:.....|  |.::||..:|::|||||.|||..|.||||||        |.....|::|
  Rat    99 ----ASVSSCTKTS--KLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTID 157

  Fly   179 GTQRHAAREVLRQHFSYIFNDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCGHIGVEYMQI 243
            ....:..:|.          ||:..|:||::|.|||.:..|||:||:.|||..||.|||:|:|.|
  Rat   158 KLAFYDLQEA----------DLDKEFRLPTTTFIGGSENTLSLREIIRRLESTYCQHIGLEFMFI 212

  Fly   244 TSLTKTNWLRDRFEKPGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLEGCDIMIPAI 308
            ..:.:..|:|.:||.||.:..:.|||:.:|.||.||..||:|||:|:|||||||||||::||||:
  Rat   213 NDVEQCQWIRQKFETPGVMKFSIEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPAL 277

  Fly   309 KEVVDRATDHGVESILIGMAHRGRLNVLANICRKPISDILSQFH-GLQATDSGSGDVKYHLGVFQ 372
            |.::|::::.|||::::||.||||||||||:.||.:..|..||. .|:|.|.||||||||||::.
  Rat   278 KTIIDKSSEMGVENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYH 342

  Fly   373 ERLNRQTNRMVRITVVANPSHLEHVNPVLLGKARAEMFQRGDTCGSTVMPIIIHGDASFSGQGVV 437
            ||:||.|||.:.:::||||||||.|:||:.||.:||.|.|||..|..||.|::||||:|:|||||
  Rat   343 ERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGRKVMSILVHGDAAFAGQGVV 407

  Fly   438 YESMHLSDLPNYTTYGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVNADDPEACIQ 502
            ||:.||||||:|||.||:|:|.|||:|||||||.:|||.|.||||:||||||.|||||||||.|.
  Rat   408 YETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVIY 472

  Fly   503 CARIAIDYRTRFKKDVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYADKLIKEGVV 567
            ...:|.::|..|.||||:|:|.|||.||||.|||||||||||::|.|..|.|:.||||||.||.|
  Rat   473 VCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHKQVPVLKKYADKLIAEGTV 537

  Fly   568 TDSEFKAMVSSYEKICEDAWAKSKTIKTIKYSSWIDSPWPGFF--EGRDRLKLCP-TGISTDTLK 629
            |..||:..::.|::|||:|:.:||..|.:....|:||||||||  :|..:....| |||..|||.
  Rat   538 TLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTYPTTGIPEDTLS 602

  Fly   630 TIGNMFSTPPPPEHKFETHKGILRILAQRTQMVQDKVADWSLGEAFAFGSLLKEGIHVRLSGQDV 694
            .|||:.|:.|..:  |:.|.|:.|||..|..|.:.:..||:|.|..|||||||||||||||||||
  Rat   603 HIGNVASSVPLED--FKIHTGLSRILRGRADMTKKRTVDWALAEYMAFGSLLKEGIHVRLSGQDV 665

  Fly   695 ERGTFSHRHHVLHHQSEDKVVYNSLDHLYPDQAPYSVSNSSLSECAVLGFEHGYSMASPNALVMW 759
            |||||||||||||.|..|:.....::||:||||||:|.||||||..|||||.||:||||||||:|
  Rat   666 ERGTFSHRHHVLHDQDVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLW 730

  Fly   760 EGQFGDFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIERFLQMSDDDPDV 824
            |.|||||.||||||||.||::|:.||||.:|:|:||||.||||||||||.|.|||||||:||.|.
  Rat   731 EAQFGDFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDA 795

  Fly   825 YPDTCDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFSPKSLLRHPLARSPFK 889
            || ....||...||.:.||||.|.||||:.||.|||||.:.||||||.|:||||||||.|:|.|.
  Rat   796 YP-VFTEDFEVSQLYDCNWIVVNCSTPASYFHVLRRQVLLPFRKPLIVFTPKSLLRHPDAKSSFD 859

  Fly   890 DFNECSCFQRIIPDKGPAGKQPDCVQKLVFCSGKVYYDLVKERDDHEQVETVALVRVEQVRRLPT 954
            .....:.|||:||:.|||.:.|:.|::|:||:|||||||||||......:.||:.|:||:
  Rat   860 QMVSGTSFQRMIPEDGPAAQSPERVERLIFCTGKVYYDLVKERSSQGLEKQVAITRLEQI----- 919

  Fly   955 RHLFLFMITMIGRILQLCPFPYDLISQQLELYPKAELLWAQEEHKNMGAWSYVQPRFDTALLKNE 1019
                             .|||:|||.::.|.|..|||:|.||||||||.:.|:.|||.|.|
  Rat   920 -----------------SPFPFDLIMREAEKYSGAELVWCQEEHKNMGYYDYISPRFMTLL---- 963

  Fly  1020 NESRCVSYHGRPPSASPATGNKVQHYNEYKALITSIFGELTPENKKRIEDR 1070
            ..||.:.|.||.|:|:||||||..|....:..:.:.|      |.|..|.:
  Rat   964 GHSRPIWYVGREPAAAPATGNKNTHLVSLRKFLDTAF------NLKAFEGK 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696	13/36 (36%)
		sucA	50..1057	CDD:236499	535/1018 (53%)
		TPP_E1_OGDC_like	282..544	CDD:238974	170/262 (65%)
		Transket_pyr	668..880	CDD:280874	150/211 (71%)
		OxoGdeHyase_C	887..1056	CDD:293475	70/168 (42%)
Ogdhl	NP_001382038.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..47		6/35 (17%)
Ogdhl	NP_001382038.1	sucA	46..1001	CDD:236499	536/1020 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335665
Domainoid	1	1.000	57	1.000	Domainoid score	I10610
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62893
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	O	PTHR23152
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.710