DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33791 and Dhtkd1

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	XP_036016106.1	Gene:	Dhtkd1 / 209692	MGIID:	2445096	Length:	940	Species:	Mus musculus

Alignment Length:	968	Identity:	363/968 - (37%)
Similarity:	523/968 - (54%)	Gaps:	114/968 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SGERTASGGASAAPAAPPSDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGIVGPKKRTSVDGTQ 181
            ||:|..:.|.|.|..        :|  |.:..::..|...||.||.::|| ..|.....:|...|
Mouse    57 SGQRARTRGGSCAAC--------VD--HGLARLVTVYCEHGHKAAQINPL-FPGQALLDTVPEIQ 110

  Fly   182 RHAAREVLRQHFSYIFNDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCGHIGVEYMQITSL 246
              |....|:..|:             ::.::...:|..||:|:|..|..||||.|.:|..|:.|.
Mouse   111 --ALVRTLQGPFT-------------TTGLLNLGKEAASLEEVLAYLNHIYCGPISIETAQLQSQ 160

  Fly   247 TKTNWLRDRFEKPGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLEGCDIMIPAIKEV 311
            .:.:|...|||:......|.||:|.:.:.|..|..|::|||.||::.||:|.||.:.|:....|:
Mouse   161 EERDWFARRFEELKKETFTTEERKYLSKLLLESQEFDHFLATKFATVKRYGGEGAESMMGFFHEL 225

  Fly   312 VDRATDHGVESILIGMAHRGRLNVLANICRKPISDILSQFHGLQ------ATDSGSGDVKYHLGV 370
            :..:...|:..|:|||.||||||:|..:.:.|...:..:..||.      ||   .|||..|| .
Mouse   226 LKLSAYGGITDIIIGMPHRGRLNLLTGLLQLPPELMFRKMRGLSEFPENVAT---IGDVLSHL-T 286

  Fly   371 FQERLNRQTNRMVRITVVANPSHLEHVNPVLLGKARAEMFQRGD---------TCGSTVMPIIIH 426
            ....|:...::.:.:|::.||||||.||||.:||.|.....|.|         ..|..|:.:.:|
Mouse   287 SSVDLDFGAHQPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSREDGDYSPNGSAQPGDKVICLQVH 351

  Fly   427 GDASFSGQGVVYESMHLSDLPNYTTYGTIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILH 491
            |||||.|||:|.|:..||:||::...|:||::.|||:|:||.....|||.|.:|:.|:|...|:|
Mouse   352 GDASFCGQGIVLETFTLSNLPHFRIGGSIHLIVNNQLGYTTPAERGRSSLYSSDIGKLVGCAIIH 416

  Fly   492 VNADDPEACIQCARIAIDYRTRFKKDVVIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQL 556
            ||.|.||..::..|:|.:|:.:|:|||::|::.||:.||||.|||.||.|:||:.|:..|.....
Mouse   417 VNGDSPEEVVRATRLAFEYQRQFRKDVIVDLLCYRQWGHNELDEPFFTNPVMYKIIRARKSIPDT 481

  Fly   557 YADKLIKEGVVTDSEFKAMVSSYEKICEDAWAKSKTIKTIKYS---SWIDSPWPGFFEGRDRLKL 618
            ||:.||..|::|..|...:.:||.....|..|     ....||   :.:.:.|.|..:....:..
Mouse   482 YAEHLIASGLMTQEEVSDIKTSYYTKLNDHLA-----NVAHYSPPATNLQARWQGLVQPEACVTT 541

  Fly   619 CPTGISTDTLKTIGNMFSTPPPPEHKFETHKGILRILAQ-RTQMVQD-KVADWSLGEAFAFGSLL 681
            ..||:..:.|:.|| :.|...|.|  .:.|..:|::..| |.:.|:: ...||:..|..|.||||
Mouse   542 WDTGVPLELLRFIG-VKSVEVPEE--LQVHSHLLKMYVQSRMEKVKNGSGLDWATAETLALGSLL 603

  Fly   682 KEGIHVRLSGQDVERGTFSHRHHVLHHQSEDKVVYNSLDHLYPDQAPY-SVSNSSLSECAVLGFE 745
            .:|.:||||||||.|||||.||.::..|..|. .|..|:|:.|:|..: .||||.|||.||||||
Mouse   604 AQGFNVRLSGQDVGRGTFSQRHAMVVCQDTDD-AYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFE 667

  Fly   746 HGYSMASPNALVMWEGQFGDFCNTAQCIIDTFIASGETKWVRQSGVVMLLPHSMEGMGPEHSSGR 810
            :|.|:.||..|.:||.|||||.|.||.|.||||:.||.||:.|||:|:||||..:|.||||||.|
Mouse   668 YGMSIESPTLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGLVILLPHGYDGAGPEHSSCR 732

  Fly   811 IERFLQMSDD-DPDVYPDTCDADFVARQLMNVNWIVTNLSTPANLFHCLRRQVKMGFRKPLINFS 874
            |||||||.|. :..|..||            ||..|.:.:|||..||.||||:...||||||..|
Mouse   733 IERFLQMCDSAEEGVDSDT------------VNMFVVHPTTPAQYFHLLRRQMIRNFRKPLIVAS 785

  Fly   875 PKSLLRHPLARSPFKDFNECSCFQRIIPDKGPAGKQPDCVQKLVFCSGKVYYDLVKERDD----- 934
            ||.|||:|.|.|..::....:.|:.:|   |.:...|..|:.|:|||||.:|.|:|:|:.
Mouse   786 PKMLLRYPAAVSTLEEMAPGTAFKPVI---GDSSVDPKNVKTLIFCSGKHFYALLKQRESLGTKK 847

  Fly   935 HEQVETVALVRVEQVRRLPTRHLFLFMITMIGRILQLCPFPYDLISQQLELYPKA-ELLWAQEEH 998
            |:    .|::|:|                      :|||||.|.:.|::..|... :::|:|||.
Mouse   848 HD----FAIIRLE----------------------ELCPFPLDALQQEMSKYKHVRDVIWSQEEP 886

  Fly   999 KNMGAWSYVQPRFDTALLKNENESRCVSYHGRPPSASPATGNKVQHYNEYKALITSIF 1056
            :|||.||:|.|||:..|   ....|.||   |||..:||.|....|..:::.:::..|
Mouse   887 QNMGPWSFVSPRFEKQL---ACRLRLVS---RPPLPAPAVGIGTVHQQQHEDILSKTF 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696
		sucA	50..1057	CDD:236499	363/968 (38%)
		TPP_E1_OGDC_like	282..544	CDD:238974	112/276 (41%)
		Transket_pyr	668..880	CDD:280874	117/213 (55%)
		OxoGdeHyase_C	887..1056	CDD:293475	51/174 (29%)
Dhtkd1	XP_036016106.1	SucA	78..939	CDD:393462	355/937 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0567
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710