DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33791 and ogdh-1

DIOPT Version :9

Sequence 1:	NP_001027100.1	Gene:	CG33791 / 317974	FlyBaseID:	FBgn0035240	Length:	1282	Species:	Drosophila melanogaster
Sequence 2:	NP_500617.1	Gene:	ogdh-1 / 177235	WormBaseID:	WBGene00020679	Length:	1029	Species:	Caenorhabditis elegans

Alignment Length:	1068	Identity:	545/1068 - (51%)
Similarity:	703/1068 - (65%)	Gaps:	59/1068 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CRLRSLARIR--RSLTLGLRGTDQHVLARQALRTIQTTSQRRGVHDLDSFANGCSAAYIEGLYNK 66
            |||.|.:||.  |:.:.|........|.:...:::....:.      :.|.||.|:.|||.:|..
Worm     8 CRLASPSRINAIRNASSGKSHISASTLVQHRNQSVAAAVKH------EPFLNGSSSIYIEQMYEA 66

  Fly    67 WKRNPSSVDESWNELFSSNDWSSPKRSPLQVSHSRKYRRPPVERIAVKARSGERTASGGASAAPA 131
            |.::||||..||:..|.:.:..:   .|.|.     ::.||....|.........|....|:|||
Worm    67 WLQDPSSVHTSWDAYFRNVEAGA---GPGQA-----FQAPPATAYAGALGVSPAAAQVTTSSAPA 123

  Fly   132 A---PPSDWKNIDDHHVIQAIIRAYQSRGHLAADLDPLGIVGPKKRTSVDGTQRHAAREVLRQHF 193
            .   ..:..::|.||..||.:||:||:|||..||||||||    ....:|.|   ...|:....:
Worm   124 TRLDTNASVQSISDHLKIQLLIRSYQTRGHNIADLDPLGI----NSADLDDT---IPPELELSFY 181

  Fly   194 SYIFNDLNTVFKLPSSTMIGGDQEFLSLKEILDRLERIYCGHIGVEYMQITSLTKTNWLRDRFEK 258
            .....||:..|.||.:|.| .:::.|:|:|||.||:.|||...|||||.:.:|.:.:|:|.|||.
Worm   182 GLGERDLDREFLLPPTTFI-SEKKSLTLREILQRLKDIYCTSTGVEYMHLNNLEQQDWIRRRFEA 245

  Fly   259 PGGLDLTKEEKKLILERLTRSTGFENFLAKKFSSEKRFGLEGCDIMIPAIKEVVDRATDHGVESI 323
            |...:|:.::||::.:||.|||.||.|||||:.||||||||||:::|||:|:|:|.::..||:|.
Worm   246 PRVTELSHDQKKVLFKRLIRSTKFEEFLAKKWPSEKRFGLEGCEVLIPAMKQVIDSSSTLGVDSF 310

  Fly   324 LIGMAHRGRLNVLANICRKPISDILSQFHGLQATDSGSGDVKYHLGVFQERLNRQTNRMVRITVV 388
            :|||.||||||||||:||:|::.|||||..|:..|.|||||||||||..||||||:.:.|:|.||
Worm   311 VIGMPHRGRLNVLANVCRQPLATILSQFSTLEPADEGSGDVKYHLGVCIERLNRQSQKNVKIAVV 375

  Fly   389 ANPSHLEHVNPVLLGKARAEMFQRGDTCGSTVMPIIIHGDASFSGQGVVYESMHLSDLPNYTTYG 453
            |||||||.|:||::||.|||.|..||......|.|::||||:|:|||||.|:.:|.|||:|||:|
Worm   376 ANPSHLEAVDPVVMGKVRAEAFYAGDEKCDRTMAILLHGDAAFAGQGVVLETFNLDDLPSYTTHG 440

  Fly   454 TIHIVSNNQVGFTTDPRFSRSSRYCTDVAKVVNAPILHVNADDPEACIQCARIAIDYRTRFKKDV 518
            .||||.|||:|||||||.||||.|||||.:||..||.|||.|||||.:....:|.|:|..|||||
Worm   441 AIHIVVNNQIGFTTDPRSSRSSPYCTDVGRVVGCPIFHVNVDDPEAVMHVCNVAADWRKTFKKDV 505

  Fly   519 VIDIVGYRRNGHNEADEPMFTQPLMYQRIKKLKPCLQLYADKLIKEGVVTDSEFKAMVSSYEKIC 583
            ::|:|.|||:||||.|||||||||||||||:.|..|:.|.:|::.|||..:...|..::.|..|.
Worm   506 IVDLVCYRRHGHNELDEPMFTQPLMYQRIKQTKTALEKYQEKILNEGVANEQYVKEELTKYGSIL 570

  Fly   584 EDAWAKSKTIKTIKYSSWIDSPWPGFFEGRDRLKLCPTGISTDTLKTIGNMFSTPPPPEHKFETH 648
            |||:..::.:..::...|:||||..||:.||.|||..|||..:.::.|...||..|   ..|..|
Worm   571 EDAYENAQKVTYVRNRDWLDSPWDDFFKKRDPLKLPSTGIEQENIEQIIGKFSQYP---EGFNLH 632

  Fly   649 KGILRILAQRTQMVQDKVADWSLGEAFAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHHQSEDK 713
            :|:.|.|..|.||::|...||:.|||.|||||||||||||||||||:||||||||||||.|..|:
Worm   633 RGLERTLKGRQQMLKDNSLDWACGEALAFGSLLKEGIHVRLSGQDVQRGTFSHRHHVLHDQKVDQ 697

  Fly   714 VVYNSLDHLYPDQAPYSVSNSSLSECAVLGFEHGYSMASPNALVMWEGQFGDFCNTAQCIIDTFI 778
            .:||.|:.|...|..|:|.||||||.||||||.||||..||:||:||.|||||.||||||||.||
Worm   698 KIYNPLNDLSEGQGEYTVCNSSLSEYAVLGFELGYSMVDPNSLVIWEAQFGDFSNTAQCIIDQFI 762

  Fly   779 ASGETKWVRQSGVVMLLPHSMEGMGPEHSSGRIERFLQM--SDDDPDVYPDTCDADFVARQLMNV 841
            :||::||:||||:||||||..|||||||||.|.||||||  .||:.|:.....:..|.|:||.:.
Worm   763 SSGQSKWIRQSGLVMLLPHGYEGMGPEHSSARPERFLQMCNEDDEIDLEKIAFEGTFEAQQLHDT 827

  Fly   842 NWIVTNLSTPANLFHCLRRQVKMGFRKPLINFSPKSLLRHPLARSPFKDFNECSCFQRIIPDKGP 906
            ||||.|.:||||::|.|||||.|.||||.:.||||||||||:||||.:||...|.|||:||:.|.
Worm   828 NWIVANCTTPANIYHLLRRQVTMPFRKPAVVFSPKSLLRHPMARSPVEDFQSGSNFQRVIPETGA 892

  Fly   907 AGKQPDCVQKLVFCSGKVYYDLVKERDDHEQVETVALVRVEQVRRLPTRHLFLFMITMIGRILQL 971
            ..:.|..|:::|||:||||||:|..|....:...|||||||                      ||
Worm   893 PSQNPPDVKRVVFCTGKVYYDMVAARKHVGKENDVALVRVE----------------------QL 935

  Fly   972 CPFPYDLISQQLELYPKAELLWAQEEHKNMGAWSYVQPRFDTALLKNENESRCVSYHGRPPSASP 1036
            .||||||:.|:...|..||:||||||||||||||:||||.::.|   ..:.|...|.||.||:||
Worm   936 SPFPYDLVQQECRKYQGAEILWAQEEHKNMGAWSFVQPRINSLL---SIDGRATKYAGRLPSSSP 997

  Fly  1037 ATGNKVQHYNEYKALITSIFGELTPENK 1064
            |||||..|..|.|.:::.:||  .|::|
Worm   998 ATGNKFTHMQEQKEMMSKVFG--VPKSK 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33791	NP_001027100.1	2-oxogl_dehyd_N	49..86	CDD:292696	16/36 (44%)
		sucA	50..1057	CDD:236499	532/1011 (53%)
		TPP_E1_OGDC_like	282..544	CDD:238974	170/261 (65%)
		Transket_pyr	668..880	CDD:280874	145/213 (68%)
		OxoGdeHyase_C	887..1056	CDD:293475	77/168 (46%)
ogdh-1	NP_500617.1	2-oxogl_dehyd_N	49..86	CDD:292696	16/36 (44%)
		sucA	51..1018	CDD:236499	532/1010 (53%)
		TPP_E1_OGDC_like	269..531	CDD:238974	170/261 (65%)
		Transket_pyr	650..866	CDD:280874	145/215 (67%)
		OxoGdeHyase_C	873..1017	CDD:293475	77/168 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156685
Domainoid	1	1.000	452	1.000	Domainoid score	I256
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62893
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000624
OrthoInspector	1	1.000	-	-		otm14804
orthoMCL	1	0.900	-	-		OOG6_100311
Panther	1	1.100	-	-	O	PTHR23152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X894
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850