Protein Alignment spirit and TMPRSS3

DIOPT Version :10

• Sequence 1: NP_572492.1
• Gene: spirit / 31797
• FlyBaseID: FBgn0030051
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_076927.1
• Gene: TMPRSS3 / 64699
• HGNCID: 11877
• Length: 454
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 100/329 - (30%)
• Similarity: 146/329 - (44%)
• Gaps: 81/329 - (24%)

  Fly    71 SALNGWLERRESPKTCYFVRFDH--------------YVCCAPAVAPIVTRSSQQACNELNKVSK 121
            |:|.|  :.||.     ||..||              ||....|...:||... .||......|.
Human   159 SSLEG--QFREE-----FVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQC-TACGHRRGYSS 215

  Fly   122 VKEIDEFFVSVVGGMPTRPREFPFMAALGWRSNFDQRIYYRCGGALIANNFVLTAAHCA-DLGGE 185
                     .:|||..:...::|:.|:|.::.      |:.|||::|...:::|||||. ||...
Human   216 ---------RIVGGNMSLLSQWPWQASLQFQG------YHLCGGSVITPLWIITAAHCVYDLYLP 265

  Fly   186 PPSQVRLGGDNLTLTEGEDISIRRVIIHPDYSASTAYNDIALLELETAAKP-----ELKPTCI-- 243
            ....:::|..:|.........:.:::.|..|......|||||::|   |.|     .::|.|:
Human   266 KSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKL---AGPLTFNEMIQPVCLPN 327

  Fly   244 -----------WTQKEVTNTLVTAIGYGQTSFAGLSSAQLLK---VPLKSVSNEECQHHYQKDQL 294
                       ||.           |:|.|......::.:|.   |||  :||:.|.|.    .:
Human   328 SEENFPDGKVCWTS-----------GWGATEDGAGDASPVLNHAAVPL--ISNKICNHR----DV 375

  Fly   295 AQGVLGTQM-CAGDITGERDTCQGDSGGPLLMQDGLLGYVVGITSLGQGCAS-GPPSVYTRVSSF 357
            ..|::...| |||.:||..|:|||||||||:.|:..|..:||.||.|.|||. ..|.|||||:||
Human   376 YGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSF 440

  Fly   358 VDWI 361
            :|||
Human   441 LDWI 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spirit	NP_572492.1	CLIP	51..98	CDD:197829	11/40 (28%)
		Tryp_SPc	132..364	CDD:238113	83/254 (33%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:464747	16/58 (28%)
		Tryp_SPc	216..444	CDD:214473	81/253 (32%)