Protein Alignment spirit and PRSS22

DIOPT Version :10

• Sequence 1: NP_572492.1
• Gene: spirit / 31797
• FlyBaseID: FBgn0030051
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: XP_054169579.1
• Gene: PRSS22 / 64063
• HGNCID: 14368
• Length: 425
• Species: Homo sapiens
• Alignment Length: 334
• Identity: 95/334 - (28%)
• Similarity: 137/334 - (41%)
• Gaps: 80/334 - (23%)

  Fly    65 RMEDCPSALNGWLERRESPKTCYFVRFDHYVCCAPAVAPIVTRSSQQACNELNKVSKVKEIDEFF 129
            |:|..|   ..|..|..||               ||:..........||.:..::::
Human   119 RLESLP---GHWRARGSSP---------------PAILNAARIPVPPACGKPQQLNR-------- 157

  Fly   130 VSVVGGMPTRPREFPFMAALGWRSNFDQRIYYRCGGALIANNFVLTAAHCAD------------L 182
              ||||..:...|:|      |..:..:...:.|.|:|:.:.:|:|||||..            |
Human   158 --VVGGEDSTDSEWP------WIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLL 214

  Fly   183 G----GEPPSQVRLGGDNLTLTEGEDISIRRVIIHPDYS-ASTAYNDIALLELETAAK--PELKP 240
            |    |.|.|:            .:.:.:..|..||.|| ...|..||||:.||.:.:  ..:.|
Human   215 GAWQLGNPGSR------------SQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLP 267

  Fly   241 TCIWTQKEV---TNTLVTAIGYGQTSFAGL-----SSAQLLKVPLKSVSNEECQHHYQKDQLAQG 297
            .|: ....:   .||.....|:|... .|:     .:.|.||||:  :.:|.|.|.|.:. ..||
Human   268 ICL-PDASIHLPPNTHCWISGWGSIQ-DGVPLPHPQTLQKLKVPI--IDSEVCSHLYWRG-AGQG 327

  Fly   298 VLGTQM-CAGDITGERDTCQGDSGGPLLMQDGLLGYVVGITSLGQGCAS-GPPSVYTRVSSFVDW 360
            .:...| |||.:.||||.|.|||||||:.|......:.||.|.|:|||. ..|.||..:|:...|
Human   328 PITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSW 392

  Fly   361 IEGIVWPAQ 369
            :|.||...|
Human   393 VEKIVQGVQ 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spirit	NP_572492.1	CLIP	51..98	CDD:197829	7/32 (22%)
		Tryp_SPc	132..364	CDD:238113	81/260 (31%)
PRSS22	XP_054169579.1	Tryp_SPc	158..396	CDD:238113	81/260 (31%)