Protein Alignment spirit and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_572492.1
• Gene: spirit / 31797
• FlyBaseID: FBgn0030051
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 85/302 - (28%)
• Similarity: 144/302 - (47%)
• Gaps: 41/302 - (13%)

  Fly    92 DHYVCCAPA------VAPIVTRSSQQACNELNKVSKVKE------------IDEFFVS--VVGGM 136
            |||   :|:      .:|....|||||.....::.:.:|            :.:....  ::||.
Human    21 DHY---SPSGRHRLGPSPEPAASSQQAEAVRKRLRRRREGGAHAEDCGTAPLKDVLQGSRIIGGT 82

  Fly   137 PTRPREFPFMAALGWRSNFDQRIYYRCGGALIANNFVLTAAHCADLGGEPPSQVR-LGGDNL--T 198
            ..:...:|::.:|  :..:.:.:.:.|||.|:...:|||||||.....:|..... :|.:|:  .
Human    83 EAQAGAWPWVVSL--QIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGR 145

  Fly   199 LTEGEDISIRRVIIHPDYSASTAYNDIALLELETAAK--PELKPTCI-WTQKEVT--NTLVTAIG 258
            ....:.|.|:.:||||::...:..|||||..|:.|.:  ..::|.|: :...::.  ||.....|
Human   146 YPHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDGNTKCFISG 210

  Fly   259 YGQTSFAGLSSAQLLKVPLKSVSNEECQHHYQKDQLAQGVL-GTQMCAGDITGERDTCQGDSGGP 322
            :|:|...|.::..|....:..:|.|.|    ..::...|:: .|..||||..|..|||:||||||
Human   211 WGRTKEEGNATNILQDAEVHYISREMC----NSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGGP 271

  Fly   323 LL--MQDGLLGYVVGITSLGQGCA-SGPPSVYTRVSSFVDWI 361
            |:  :.:....:|:||||.|.||. .|.|.||...|.:..|:
Human   272 LMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPSFYQKWL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spirit	NP_572492.1	CLIP	51..98	CDD:197829	3/5 (60%)
		Tryp_SPc	132..364	CDD:238113	74/242 (31%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46		7/21 (33%)
		Tryp_SPc	78..316	CDD:238113	74/242 (31%)