DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Phlpp1

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_598582.3	Gene:	Phlpp1 / 98432	MGIID:	2138327	Length:	1687	Species:	Mus musculus

Alignment Length:	599	Identity:	117/599 - (19%)
Similarity:	199/599 - (33%)	Gaps:	211/599 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVYMTLPIAFYQGSSVYVLGMVVSII------- 179
            |.|::|.::.||      |:|:..|           ::|.......|...|..|.:.:
Mouse   649 LKSLNLSNNHLG------AFPSAVC-----------SIPTLAELNVSCNALREVPAAVGDMQNLQ 696

  Fly   180 -YIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQL 243
             ::....::|.|..::......||      |.|.|:.||.|.:
Mouse   697 TFLLDGNFLQSLPAELESMHQLSY------LGLSFNEFTDIPE---------------------- 733

  Fly   244 VMKKENGLLESILPRKMIRTLQEEICSRIE-----DQDKNFTPSKAGLRKLFLEPYPNVSILVAD 303
            |::|...:.:..:....:.||:.:...|:.     |...|.      |||           |:||
Mouse   734 VLEKLTAVDKLCMAGNCVETLRLQALRRMPHIKHVDLRLNI------LRK-----------LMAD 781

  Fly   304 MVNYTHLTTTLEAP------------QLVEILH---DLFVNFD--------LAANRNRAMR---- 341
            .|::....|.|:..            ..:|:||   :..|..:        |.|:.|...:
Mouse   782 EVDFVQHVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLNVCGYFLKALYASSNELAQLDVY 846

  Fly   342 -----IKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFA 401
                 :.::..|.||:..:|.:      .|..:.||::.|  |.:...||...|.......::.|
Mouse   847 PVPNYLSYMDVSRNCLESVPEW------VCESRKLEVLDI--GHNQICELPARLFCNSSLRKLLA 903

  Fly   402 GIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAG 466
               ||               |||  :.||  ..:.:.::.:||..:  .:.||...|  :|.:|.
Mouse   904 ---GH---------------NRL--ARLP--ERLERTSVEVLDVQH--NQITELPPN--LLMKAD 942

  Fly   467 IRTFL--VSNRLPDAVEPGELDDELSSA-----SINSCRLS-----YGGY---------YEEIQI 510
            ...||  .:|:| :.:.|..|.:|.||.     ..|:|...     ..|:         |..:|.
Mouse   943 SLRFLNASANKL-ETLPPATLSEETSSILQELYLTNNCLTDKCVPLLTGHPRLKILHMAYNRLQS 1006

  Fly   511 -----KAQREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLG------VFRSWK 564
                 .|:.|.::|:|             .|..|.:......:...::|.|:.      ||.
Mouse  1007 FPASKMAKLEELEEID-------------ISGNKLKAIPTTIMNCRRMHTVIAHSNCIEVFP--- 1055

  Fly   565 REWEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGILLILLILCILAGYKKLRL 629
               |...||:         |.|..|   |.|.:.|.|.|:.|.      ..|....|.|..:|.|
Mouse  1056 ---EVMQLPE---------VKCVDL---SCNELSEITLPENLP------PKLQELDLTGNPRLAL 1099

  Fly   630 QWKKLTPMSQPSCF 643
            ..|.|..::...||
Mouse  1100 DHKSLELLNNIRCF 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	43/234 (18%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	34/184 (18%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Phlpp1	NP_598582.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..406
		PH_PHLPP-like	491..587	CDD:270131
		PH	511..592	CDD:278594
		LRR_RI	581..885	CDD:238064	54/305 (18%)
		LRR_8	594..659	CDD:290566	3/9 (33%)
		LRR 1	594..615
		leucine-rich repeat	597..617	CDD:275380
		LRR 2	617..638
		leucine-rich repeat	618..648	CDD:275380
		LRR_8	647..726	CDD:290566	18/99 (18%)
		LRR 3	648..669		8/36 (22%)
		LRR 4	671..692		3/20 (15%)
		leucine-rich repeat	672..694	CDD:275380	3/21 (14%)
		LRR 5	694..715		2/20 (10%)
		leucine-rich repeat	695..717	CDD:275380	2/21 (10%)
		LRR 6	717..739		10/49 (20%)
		leucine-rich repeat	718..740	CDD:275380	10/49 (20%)
		LRR 7	740..760		2/19 (11%)
		leucine-rich repeat	741..764	CDD:275380	3/22 (14%)
		LRR 8	764..785		9/37 (24%)
		LRR_RI	768..1030	CDD:238064	65/326 (20%)
		leucine-rich repeat	768..788	CDD:275380	9/36 (25%)
		LRR 9	788..809		2/20 (10%)
		leucine-rich repeat	789..809	CDD:275380	2/19 (11%)
		leucine-rich repeat	810..851	CDD:275380	7/40 (18%)
		LRR 10	829..850		3/20 (15%)
		LRR 11	851..872		5/26 (19%)
		leucine-rich repeat	852..874	CDD:275380	5/27 (19%)
		LRR 12	874..895		7/22 (32%)
		leucine-rich repeat	875..897	CDD:275380	7/23 (30%)
		LRR_8	896..954	CDD:290566	18/83 (22%)
		LRR 13	897..918		8/42 (19%)
		leucine-rich repeat	898..919	CDD:275380	8/42 (19%)
		LRR 14	919..940		6/24 (25%)
		leucine-rich repeat	920..943	CDD:275380	7/26 (27%)
		LRR 15	943..964		6/21 (29%)
		leucine-rich repeat	944..967	CDD:275380	7/23 (30%)
		LRR 16	969..989		2/19 (11%)
		LRR_8	970..1028	CDD:290566	10/70 (14%)
		leucine-rich repeat	970..993	CDD:275380	3/22 (14%)
		LRR 17	993..1014		2/20 (10%)
		leucine-rich repeat	994..1017	CDD:275380	3/22 (14%)
		LRR 18	1017..1038		4/33 (12%)
		LRR 19	1040..1061		5/26 (19%)
		LRR 20	1062..1083		8/32 (25%)
		leucine-rich repeat	1063..1085	CDD:275380	9/30 (30%)
		LRR 21	1085..1106		7/20 (35%)
		PP2Cc	1124..1376	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1414..1465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1604..1687
		PDZ-binding	1685..1687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900