DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	476	Identity:	102/476 - (21%)
Similarity:	188/476 - (39%)	Gaps:	126/476 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 MVPYFAVMLFSPFIMLLSMQNNVGMITNTL------ISWLMALFLTSMDLVSDLLGTIYSGAAYP 142
            :||:|.|....|.|.:::.....|.:.:.:      |.|:..|.. :.|:|:.||  ...|:
Mouse   615 IVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSF-AYDIVNGLL--FLHGS--- 673

  Fly   143 TVPCYDH------VVLVSVYMTLPIA------FYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVS 195
              |...|      ..||..:|.|.::      |..||:              :..|.|...|...
Mouse   674 --PLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGST--------------WRSYNQEATDHSE 722

  Fly   196 FYLLASYAIYL-------FTLNLIFSFFTIIRDYGLRRA-------------ILSR--------- 231
            .|..|...:.|       .....::||..::||...::|             |:||
Mouse   723 LYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPFEDLEAAPEEIISRIKDPRAPVP 787

  Fly   232 ---------------------------YQLVYQNIVYQLVMKKENG---LLESILPRKMIRTLQE 266
                                       .:.::.:|...|......|   :|:|::.:  :.|...
Mouse   788 LRPSLLEDKGDGRIVALVRECWDESPELRPIFPSIKKTLREASPRGHVSILDSMMGK--LETYAN 850

  Fly   267 EICSRIEDQDKNFTPSKAGLRKLF-----------------LEP--YPNVSILVADMVNYTHLTT 312
            .:...:|::.:.....|..:.||.                 :||  :.:|:|..:|:|.:|.|.:
Mouse   851 HLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCS 915

  Fly   313 TLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPA-HASCCVDQALEMIHI 376
            .....|:|::|:||:..||.....:...:::.:||:|...:|:|....| ||......||.::.:
Mouse   916 LSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSV 980

  Fly   377 TQ--GVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRT 439
            |.  .:....|..:.||||:|:|.|.||::|.|..::.::...|::.:|:|||.||..:||||.|
Mouse   981 TTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQST 1045

  Fly   440 LSML---DEHYIFREGTEAAK 457
            ...|   ..:::.:.||.:.|
Mouse  1046 AGALLAAGGYHLQKRGTISVK 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	58/222 (26%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	51/160 (32%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595
		PK_GC	555..829	CDD:270894	40/235 (17%)
		CYCc	865..1055	CDD:214485	54/189 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900