DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and Adcy3

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_570135.2	Gene:	Adcy3 / 64508	RGDID:	71009	Length:	1144	Species:	Rattus norvegicus

Alignment Length:	1216	Identity:	299/1216 - (24%)
Similarity:	527/1216 - (43%)	Gaps:	244/1216 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NPYYQEDVVAYRSLSTVKDLE---WRHLKNKCQNLRLELACSRLRELALMSNVVQIIWHVELLMV 66
            :|.|..:..|..|:|...|.:   .|..:...:|....|...|...|..:...::.::.......
  Rat     9 DPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQ 73

  Fly    67 AHVILLLALVKDIILVTMVPYFAVMLFSPFIMLLSMQNNVGM------------------ITNTL 113
            .|..||:.:|...:....|.....::||...:...|...||:                  ::..:
  Rat    74 RHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFVLCKKGLLPDRVSRKV 138

  Fly   114 ISWLMALFLTSMDLVSDLLGTIYS--GAAYPTVPCYDHVVLVSVYMTLPIAFYQGSSVYVLGMVV 176
            :.:|:.|.:|:.  :...||..:|  .||..||. :....:.|.::|||::......:.|:..||
  Rat   139 VPYLLWLLITAQ--IFSYLGLNFSRAHAASDTVG-WQAFFVFSFFITLPLSLSPIVIISVVSCVV 200

  Fly   177 SIIYIGYAFYMQYLND----QVSFYLLASYAIYLFTLNL-IFSFFTIIRDYGLRRAILSRYQLVY 236
            ..:.:|.....|..::    |:...:||:..:||..:.: |.|::...|.:  |:|.|...|.:.
  Rat   201 HTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKH--RKAFLEARQSLE 263

  Fly   237 QNIVYQLVMKKENGLLESILPR----KMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNV 297
            ..:..:...:::..|:.||||:    :|::.::::...:.:.|          ...:::..:.||
  Rat   264 VKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQ----------FNTMYMYRHENV 318

  Fly   298 SILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAH 362
            |||.||:|.:|.|::...|.:||::|::||..||..|.:...:|||.|||.|.|:.|:|:|...|
  Rat   319 SILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDH 383

  Fly   363 ASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESS 427
            |.|.:...|.|:.....|..:.:..:::|:|||:|.|..|::|..:||:|:||.||.:.|::|:.
  Rat   384 AVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAG 448

  Fly   428 GLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPD------------AV 480
            |:||.||:||.|:..|...:....|...::.| .|.:.||.|:|:....|:            |:
  Rat   449 GIPGRVHISQSTMDCLKGEFDVEPGDGGSRCD-YLDEKGIETYLIIASKPEVKKTAQNGLNGSAL 512

  Fly   481 EPGELDDELSSASI------NSCRLSYGGYYEEIQIKAQREIMKEVDQMAVGHCFIEWRR----- 534
            ..|....:.||.::      |....:.|...||.:         |.:..|....|...||
  Rat   513 PNGAPASKPSSPALIETKEPNGSAHASGSTSEEAE---------EQEAQADNPSFPNPRRRLRLQ 568

  Fly   535 -------SSSMKKQDFNE---EYLFSNQIHLVLGVFRSWKREWEFHNLPDLMIKYTM-------L 582
                   .:|..:.:.|:   |.|...:...|:....::.....|.: |::..:|::       .
  Rat   569 DLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMD-PEMETRYSVEKEKQSGA 632

  Fly   583 LVLCAGLAIMSINLIEEATYPDIL------VLLGILLILLILCILAGYKKLRLQWKKLTPMSQPS 641
            ...|:.:.:....::|....|.::      |:..:||::|.:|.:|.          :.|.:.|
  Rat   633 AFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAA----------IFPRAFP- 686

  Fly   642 CFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKSYAE 706
                :.|:..|..|:.:.:.|....|:.:.:|.:.:...:.||         ::.::
  Rat   687 ----KKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSC---------LQYYM-------- 730

  Fly   707 CFGPWTVT---------------YCVVIVISLLFVVPGCPL--VIKILAGLLILGLHLGTVHLY- 753
              ||:.||               |..|.|:||:..:....:  ::|:...||:.|. :..::||
  Rat   731 --GPYNVTTGIELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGA-VTAINLYA 792

  Fly   754 -------YG-----------FAFERSET--------TDLGL---KSDYAHTWYLVALFIVLVLRE 789
                   |.           .|.|:.:.        ||..|   .|.|:.|..:..:.:......
  Rat   793 WCPVFDEYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFS 857

  Fly   790 RHVNYLRKFNYFMRVCYEEAHQQTD---EKLRSIKIIMANILPTHVAQVYKVRRPHD-QLYYENF 850
            |||..|.:..:..::   |.|.|.:   |..|..:.::.|:||.|||:.:...:..| :||.:::
  Rat   858 RHVEKLARTLFLWKI---EVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSY 919

  Fly   851 SKVAVMFASIENF----------NADTAGLRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMV 905
            .::.|||||:.||          |.....||.|:|||..||.||.:.:.|. |.|||.:|.|||.
  Rat   920 DEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRV-ITKIKTIGSTYMA 983

  Fly   906 ACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLV 970
            |.|:..|                         |.|..|.|:..:|.|.....|..|.:.|
  Rat   984 ASGVTPD-------------------------VNTNGFTSSSKEEKSDKERWQHLADLAD----- 1018

  Fly   971 MTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASR 1035
               |||    .|.|...|.....::.|:   |:||::.|.|:|||:|..||||||||:|||:|||
  Rat  1019 ---FAL----AMKDTLTNINNQSFNNFM---LRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASR 1073

  Fly  1036 MSSTGLLDNIQVTRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLV 1081
            |.|||::.||||...|..:||::..|...||...|||.|::.|:.:
  Rat  1074 MESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFL 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	69/201 (34%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	62/152 (41%)
		CYCc	814..1056	CDD:214485	89/255 (35%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	90/245 (37%)
Adcy3	NP_570135.2	AC_N	<44..303	CDD:318454	50/263 (19%)
		Guanylate_cyc	310..494	CDD:306677	69/184 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..563		11/67 (16%)
		Guanylate_cyc	914..1121	CDD:306677	90/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810