DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and gucy2ca

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	1226	Identity:	233/1226 - (19%)
Similarity:	384/1226 - (31%)	Gaps:	516/1226 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 LIFSFFTIIRDYGLRRAILS-RYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIED 274
            |.|.:.:::...|..  :|| |...|..|:|   :::.||    |....|.::.:.|   :.:||
Zfish     7 LCFCWVSLLGVSGFN--VLSCRNSSVTLNVV---LLEDEN----SPWSLKFVKDVVE---TAVED 59

  Fly   275 Q-DKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHL------TTTLEAPQLVEILHDLFVNFDL 332
            | :||..   .||..       ::.:|.:.. |.||.      ::|.||.::::.||:
Zfish    60 QNNKNHA---EGLDF-------HIKVLFSGF-NTTHYRRRGCGSSTCEAVEILKSLHN------- 106

  Fly   333 AANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSG 397
                |..:....||.|                 |.....:::.        :|:.:.|.|.:
Zfish   107 ----NSELGCVMLGPS-----------------CTYATFQLVD--------QEVGLTLTIPI--- 139

  Fly   398 EVFAGIIG---------------------------HTK-------WQFD-IWSKDVDIT------ 421
             :.||..|                           ||.       |:.. ::.|| :.|
Zfish   140 -ISAGSFGLSCDYKQKLTRLLPPARKIAEFFFHFWHTSVKNLKPAWKTAYVYKKD-NYTEECFWY 202

  Fly   422 -NRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAA-------KNDPILQQAG----IRTFLVSN 474
             |.||:   |..:..|..:..||      |..:|.:       ::..|:...|    |.|...:|
Zfish   203 INALEA---PSALFSSNISREML------RSESELSTALKRKDRHSNIIVMCGTPDDIYTIKKNN 258

  Fly   475 RLPDAV-----------------EPGELDDEL----------SSASI--NSCRLSYGGYYEEIQI 510
            .:|..|                 .|..:.:.|          ||.|:  |:..:|.||||
Zfish   259 TVPSQVVFILIDLYNEGYRTNESSPAHMRNVLVLTMHSFRNYSSNSVWRNNTTVSIGGYY----- 318

  Fly   511 KAQREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLGVF---RSWKR------- 565
                                   :..|...:|.|...:::...:....:|   .|..|
Zfish   319 -----------------------KLDSSGDRDLNLSVVYTTGSYKYRTLFSFDTSQNRTKVKDSS 360

  Fly   566 ---EWEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGILLILLILCILAGY--- 624
               .|:...||  ..|:|       |:.|..|          ::::||:.::|..:.....|
Zfish   361 PDLPWDRSQLP--RDKHT-------GMEIQEI----------MMIVLGLSVVLATVIAFILYRQN 406

  Fly   625 KKLRLQWKK--------LTPM-SQPSCFLSRWLLRISE-------------------------RI 655
            :::|...||        :||: .:...::|   |.|.|                         |.
Zfish   407 RRVRFDQKKWSHISSSLITPLDDKERNYIS---LTIDEDKKGDNSSLIRKGRYDKKPVILKELRN 468

  Fly   656 EDSLFV---RIPLTMVVLL-----------------------------LLYVMSSQAVFSCDVAK 688
            .|..|.   ||.|..::.:                             |.||:..:..:. |.:.
Zfish   469 TDGNFTDDQRIELNALLRIDYYNLTKFYGTVRFDCGVFGVFEFCERGSLRYVLDDKISYP-DASF 532

  Fly   689 LEL--------SIIEAHLYNEKSYAECFGPWTVTYCVV---IVISLLFVVPGCPLVIKILAGLLI 742
            ::|        .|.:...|...|.....|....|.|||   :|:.:...  ||..::.....|..
Zfish   533 MDLEFRISVMYDIAKGMSYLHSSNVGVHGRLKSTNCVVDNRMVVKITDF--GCNTILSPGKDLWT 595

  Fly   743 LGLHL--------GTVHLYYGFA------FERSETTDLGLKSDYAHTWYLVALFIVLVLRERHVN 793
            ...|:        |.|   |.||      ..|.........||.|...||             |.
Zfish   596 APEHMRVEGISQKGDV---YSFAIISQEIILRKSPFHTSCCSDMAEKLYL-------------VQ 644

  Fly   794 YLRKFNYF-------------------MRVCYEE---------------------AHQQT----- 813
            |.|..|.|                   ::.|:||                     .|.|.
Zfish   645 YPRGPNVFRPDLSFEGVGETEAELFVLIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYM 709

  Fly   814 DEKLRSIKIIMANILPTHVAQ----VYKVRRPH-DQLYY-------------------ENFSKVA 854
            |..:|.:::...|:  .|:.:    :||..|.. |||.:                   |.:.:|.
Zfish   710 DNLIRRLQMYSRNL--EHLVEERTALYKAERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVT 772

  Fly   855 VMFASIENF------NADTAGLRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLETDH 913
            :.|:.|..|      :.....:.:|::|...||.:| |:...||:|.|   |..||||.||...:
Zfish   773 IYFSDIVGFTTICHHSTPMEVVDMLNDIYKNFDSIL-DHHDVYKVETI---GDAYMVASGLPRCN 833

  Fly   914 YTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDL 978
            ....::||.:                                                  .|||:
Zfish   834 GNRHAVDICL--------------------------------------------------MALDI 848

  Fly   979 LRIMHDIRYNYVFSEYDTFLTGS---LKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTG 1040
            |..|...:..:        |.|.   ::|||..|...|||||...|.|.::|.|||.||||.|||
Zfish   849 LEFMGTFQLRH--------LPGIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTG 905

  Fly  1041 LLDNIQVTRHTAKVLRQFN--IRCNYRGHTEVKGVGKVPTYLVVVDPDLTFQDHDQVSMSMKDSK 1103
            |...|.|:..|.|:|::.:  ..|..||.|.:||.||..||
Zfish   906 LPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGKEMTY------------------------ 946

  Fly  1104 SWVIDTLSLSFTPSFVPPKSSTSDEEEAEGELEENV-----SEGDELEVSIHERQK 1154
             |:.......::   :|...:..:.:..:.:|.|.:     ..|:|...::..||:
Zfish   947 -WLTGVTGQKYS---LPTPPTVENFQRLQQDLAERIVSTLNKRGNERRKTLSTRQR 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	43/246 (17%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	33/200 (17%)
		CYCc	814..1056	CDD:214485	68/274 (25%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	70/265 (26%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	73/432 (17%)
		PKc_like	428..698	CDD:304357	47/291 (16%)
		Pkinase_Tyr	451..689	CDD:285015	43/256 (17%)
		CYCc	736..929	CDD:214485	63/254 (25%)
		Guanylate_cyc	763..950	CDD:278633	70/273 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000