Protein Alignment CG32305 and adcy3a

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: XP_009290286.1
• Gene: adcy3a / 571825
• ZFINID: ZDB-GENE-111027-6
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1163
• Identity: 301/1163 - (25%)
• Similarity: 509/1163 - (43%)
• Gaps: 262/1163 - (22%)

  Fly    51 MSNVVQIIW----HVELLMVAHVILLLALVKD--IILVTMVPYFAVMLFSPFI--------MLLS 101
            :.|:.|..:    |..||    |:::.|.:.|  ||::..|.|.|..|.|..:        :||.
Zfish    62 LENLYQTYFRRQRHETLL----VLVVFAALFDCYIIVMCTVLYTADKLASVAVASVGLAADVLLY 122

  Fly   102 MQNNVGM----ITNTLISWLMALFLTSMDLVSDLLGTIYSGAAYP--TVPCYDHVVLVSVYMTLP 160
            :....|:    :|..|:.:  ||::.....:...||..::....|  ||. :......|.::|||
Zfish   123 LLCRYGLLPDRVTRRLVPY--ALWVLIAAQIFCYLGLNFARFHQPSDTVG-WQAFFSFSFFLTLP 184

  Fly   161 IAFYQGSSVYVLGMVVSIIYIGYAFYMQYLND----QVSFYLLASYAIYLFTLNL-IFSFFTIIR 220
            :.......:..:...|..:.:|.....|...|    .:...|||:..||:..:.: :.|::...|
Zfish   185 LRLTPIVLITSVSCGVHTLVLGVTIAQQQQEDIQGAALGRQLLANMVIYVCAITVGVMSYYMADR 249

  Fly   221 DYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPR----KMIRTLQEEICSRIEDQDKNFTP 281
            .:  |:|.|...|.:...:..:...:::..||.||||:    :|::.:::| .|:.|.|..|
Zfish   250 KH--RKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADEMLQDMKKE-ASQKEMQQFN--- 308

  Fly   282 SKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLG 346
                  .:::..:.|||||.||:|.:|.|:::..|.:||::|::||..||..|.:...:|||.||
Zfish   309 ------TMYMYRHENVSILFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILG 367

  Fly   347 DSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQF 411
            |.|.|:.|:|:|...||:|.:...|.|:.....|..:.:.|:::|:|||||.|..|::|..:||:
Zfish   368 DCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVDMRVGVHSGTVLGGVLGQKRWQY 432

  Fly   412 DIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRL 476
            |:||.||.:.|::|:.|:||.||:||.||..|...:....|....:.: .|::.||.|:||.  |
Zfish   433 DVWSTDVTVANKMEAGGIPGRVHISQNTLECLHGEFDVEPGNGGDRCE-YLKERGIETYLVV--L 494

  Fly   477 PDAVEPGELDDELSSASINSCRLSY-----------------GGYYEEIQIKAQREIMKEVDQMA 524
            |..        .:....||..:||.                 |..:.........|   |:|...
Zfish   495 PKG--------PVGKNGINGVKLSVTSSNGNSPLLINTTECNGSVHTACTTPEDPE---ELDTRV 548

  Fly   525 VGHCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLGVFRSWKREWEFHNLPD-----------LMIK 578
            |...|...||  .::.:|..|.            |..:.:.|.|.:.|.:           |..|
Zfish   549 VNPSFPNPRR--RLRLRDLAER------------VIDAQENEQELNKLLNEALLERETVQALKGK 599

  Fly   579 YTMLLVL------------------------CAGLAIMSINLIEEATYPDI------LVLLGILL 613
            ||..|.|                        |:.:.::...::|....|.:      |.:..:||
Zfish   600 YTNRLSLRFTDPELETRFSVEKEKQSGAAFSCSCVVLLFTAVMEALIDPWLVANYVTLAVGEVLL 664

  Fly   614 ILLILCILAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSS 678
            ::|.:|.||..              .|..|..| |:..|..|:.:.:.|....|..:.::.:...
Zfish   665 LILTICSLAAI--------------FPRVFPKR-LVSFSTWIDHTRWARNTWAMAAIFIVTLADI 714

  Fly   679 QAVFSCDVAKLELSIIEAHLYNEKSYAECFGPWTVT-----------YCVVIVISLLFVVPGCPL 732
            ..:.||...  :.|.:|:...          |..||           |..:.|::|:    ...:
Zfish   715 VDMLSCRAP--QTSTVESTAV----------PPVVTAIRGCAENPKYYSFIAVLALI----ATTM 763

  Fly   733 VIKI-----LAGLLILGLHLGTVHLYYGFAFERSETTDLG------------LKSDYAHTWYLVA 780
            ::::     |..:|::.:..|.|::|     ..|:|.||.            :.|.|..:   |.
Zfish   764 LVQVSHMVKLTLMLLITVATGAVNIY-----SWSQTFDLYDLTRFKEYRVNLVPSKYTMS---VM 820

  Fly   781 LFIVLV---LRERHVNYLRKFNYFMRVCYEEAHQQTD---EKLRSIKIIMANILPTHVAQVYKVR 839
            :||::|   ...|||..|.:..:..::   |.|:|.:   |..|..:.::.|:||.|||:.:...
Zfish   821 IFIMMVSFYYFSRHVEKLARTLFLWKI---EVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGS 882

  Fly   840 RPHD-QLYYENFSKVAVMFASIENF----------NADTAGLRILHEIICCFDDLLVDYQTRYKI 893
            :..| :||.:::.::.||||||.||          |.....||.|:|||..||.||.:.|.|. |
Zfish   883 KKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFRC-I 946

  Fly   894 EKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQ 958
            .|||.:|.|||.|.|:.:|:.|:                         .:...:.:|:|.....|
Zfish   947 TKIKTIGSTYMAASGVTSDNNTN-------------------------GYACMKKEEISDRERWQ 986

  Fly   959 PYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHY 1023
            ..|.:.|        |||.:...:.:|.|    ..::.|:   |:||::.|:|:|||:|..|||:
Zfish   987 HLADLAD--------FALAMKVTLMNINY----QSFNNFM---LRIGLNKGAVLAGVIGARKPHF 1036

  Fly  1024 DIWGHTVNMASRMSSTGLLDNIQVTRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLV 1081
            ||||:|||:||||.|||::.||||......:|:.:..|...||...|||.|::.||.:
Zfish  1037 DIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTYFL 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/201 (38%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	65/152 (43%)
		CYCc	814..1056	CDD:214485	85/255 (33%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	86/245 (35%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831	55/251 (22%)
		CYCc	273..468	CDD:214485	77/204 (38%)
		Guanylate_cyc	310..492	CDD:278633	70/182 (38%)
		CYCc	858..1075	CDD:214485	86/257 (33%)
		Guanylate_cyc	889..1096	CDD:278633	86/247 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810