Protein Alignment CG32305 and adcy6a

DIOPT Version :10

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: XP_017209219.1
• Gene: adcy6a / 570652
• ZFINID: ZDB-GENE-060221-1
• Length: 1203
• Species: Danio rerio
• Alignment Length: 1211
• Identity: 311/1211 - (25%)
• Similarity: 523/1211 - (43%)
• Gaps: 284/1211 - (23%)

  Fly    10 EDVVAYRSLSTVKDLEWRHL-----KNKCQNLRLELACSRL------RELALMSNVVQIIWHVEL 63
            ||..:.....|..|. |:.:     ..|.|:.:||....|.      ..|.::..|        |
Zfish   131 EDTASGTGSVTAADC-WQRVVRVFQSKKFQSRKLERLYQRYFFRLNQSSLTMLMGV--------L 186

  Fly    64 LMVAHVILLLALV---KDIILVTMVPYFAVMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSM 125
            ::|..|:|....:   .|::..:::.    :..:.|:.|:.:.|..|...:.:  |:::..:..:
Zfish   187 VIVCGVMLTFHCIHGPPDVVYASVLS----VAMALFLALMVVCNRNGFHQDYM--WMVSYLVIGV 245

  Fly   126 DLVSDLLGTIYSGAAYPTVPCYDHVVLV-SVYMTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQY 189
            .::..:.|.:.......:...:..|..: .:|..||:..   .:..:.|.|:|.|::...:.:..
Zfish   246 LIIVQVFGVLMVAPRSASEGIWWSVFFIYIIYTLLPVRM---RAAVLSGGVLSAIHLLTTWRINQ 307

  Fly   190 LNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKEN----G 250
            .::.:...|.|:..|:|.| |:|    .|...|....:....:|.....|..:|.:::||    .
Zfish   308 DDEFLWKQLSANVLIFLCT-NII----GICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQER 367

  Fly   251 LLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLE 315
            ||.|:|||.:...::.:|.::.||.         ...|::::.:.|||||.||:..:|.|.:...
Zfish   368 LLLSVLPRHVAMEMKADINAKKEDM---------MFHKIYIQKHDNVSILFADIEGFTSLASQCT 423

  Fly   316 APQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGV 380
            |.:||..|::||..||..|:.|..:|||.|||.|.||:|:|.....||.|||:..::||   :.:
Zfish   424 AQELVMTLNELFARFDKLASENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMI---EAI 485

  Fly   381 SSRRE---LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSM 442
            |..||   :::|:|:|:|||.|..|::|..|||||:||.||.:.|.:|:.|..|.:|:::.||..
Zfish   486 SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQY 550

  Fly   443 LDEHYIFREGTEAAKNDPILQQAGIRTFLV-----------------------SNRLPDAVEPGE 484
            |:..|....|....:| ..|::..|.||||                       ||   :|:.|..
Zfish   551 LNGDYEVEPGFGGERN-AYLKENSIETFLVLGCSQKRKDEKAMMAKMQRTRTNSN---EALVPRW 611

  Fly   485 LDDELSSASINSCRLSYGGYYEEIQIKAQREIMK------EVDQMAVGHCFIEWRRSSSMKKQDF 543
            :.|...|.:.:|......| .:|...|..|...:      |||:. :|.. |:.|....::| |.
Zfish   612 VPDRSFSRTKDSKVFRQMG-IDETSSKDNRGAQEALNPEDEVDEF-LGRA-IDARSIDQLRK-DH 672

  Fly   544 NEEYLFSNQIHLVLGVFRSWKREWEF-HNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILV 607
            .:::|.:         |::...|.:: ..:.|....|    |.|..|....|:.|:...:|..||
Zfish   673 VKKFLLT---------FQTSSLEKKYAKKVDDRFGGY----VACTLLVFCFISFIQIVVFPHTLV 724

  Fly   608 LLGI---LLILL--ILCILAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVRIPLTM 667
            :|||   :.|:|  ||.|.|.|..:     ||.|.:..:         :|::|..|   |...|:
Zfish   725 MLGIYISIFIILANILFICAIYSCV-----KLFPAAMQT---------VSKKIVQS---RTNSTL 772

  Fly   668 V---VLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKSYAECFGP---WT---VTYCVVIVISL 723
            |   .::|:::.:...:||||..||               .:|...   |:   ||.|::..:|.
Zfish   773 VGVFTIILVFISAFVNMFSCDTQKL---------------VDCVAKQLNWSSEMVTPCIIHNMSR 822

  Fly   724 LFV---------VPGCP--------LVIKILA----------GLLILGLHLGTVHLYY------- 754
            ...         .|.||        :::.:||          |.|.|.|.:....|..
Zfish   823 SVADGLSICPNNTPSCPFPEYFSYSVLLTLLACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVA 887

  Fly   755 ------------GFAFERS---------------ETTDLGLKSDYAHTWYLVALFIV-LVLRERH 791
                        ...|..:               ..|.:.||   ..|..::.:|:: |.|..:.
Zfish   888 LFDNADLFVTANALVFNETLQWSNFNTTTEQCTFRVTKVSLK---VMTPVILTVFVLALYLHAQQ 949

  Fly   792 VNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVR-RPHDQLYYENFSKVAV 855
            |....:.::..::...|..::.:|.....:.::.||||..||..:..| |.:|:|||::...|||
Zfish   950 VESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAV 1014

  Fly   856 MFASIENFN-------ADTAG---LRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLE 910
            |||||.||:       |:..|   ||:|:|||..||:::.:.:.| ::||||.:|.|||.|.||.
Zfish  1015 MFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKYR-QLEKIKTIGSTYMAASGLN 1078

  Fly   911 TDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFA 975
            ...|              |.|   |.|.:|                             .:.::|
Zfish  1079 DSTY--------------DKE---GRSHIT-----------------------------ALADYA 1097

  Fly   976 LDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTG 1040
            :.|...|..|. .:.|:.:      .:|||::.|.|:|||:|..||.|||||:|||:||||.|||
Zfish  1098 MHLREQMKYIN-EHSFNNF------QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG 1155

  Fly  1041 LLDNIQVTRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLV 1081
            :.|.||||....:||.....:...||..:|||.|::.||.:
Zfish  1156 VPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFL 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	AcyC	62..451	CDD:441717	110/399 (28%)
		Nucleotidyl_cyc_III	292..445	CDD:448371	66/155 (43%)
		Nucleotidyl_cyc_III	845..1081	CDD:448371	87/245 (36%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	54/295 (18%)
		Guanylate_cyc	397..559	CDD:425528	67/164 (41%)
		Adcy_cons_dom	609..697	CDD:461877	20/100 (20%)
		Guanylate_cyc	1004..1197	CDD:425528	87/247 (35%)