DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and adcy6a

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	XP_017209219.1	Gene:	adcy6a / 570652	ZFINID:	ZDB-GENE-060221-1	Length:	1203	Species:	Danio rerio

Alignment Length:	1211	Identity:	311/1211 - (25%)
Similarity:	523/1211 - (43%)	Gaps:	284/1211 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EDVVAYRSLSTVKDLEWRHL-----KNKCQNLRLELACSRL------RELALMSNVVQIIWHVEL 63
            ||..:.....|..|. |:.:     ..|.|:.:||....|.      ..|.::..|        |
Zfish   131 EDTASGTGSVTAADC-WQRVVRVFQSKKFQSRKLERLYQRYFFRLNQSSLTMLMGV--------L 186

  Fly    64 LMVAHVILLLALV---KDIILVTMVPYFAVMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSM 125
            ::|..|:|....:   .|::..:::.    :..:.|:.|:.:.|..|...:.:  |:::..:..:
Zfish   187 VIVCGVMLTFHCIHGPPDVVYASVLS----VAMALFLALMVVCNRNGFHQDYM--WMVSYLVIGV 245

  Fly   126 DLVSDLLGTIYSGAAYPTVPCYDHVVLV-SVYMTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQY 189
            .::..:.|.:.......:...:..|..: .:|..||:..   .:..:.|.|:|.|::...:.:..
Zfish   246 LIIVQVFGVLMVAPRSASEGIWWSVFFIYIIYTLLPVRM---RAAVLSGGVLSAIHLLTTWRINQ 307

  Fly   190 LNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKEN----G 250
            .::.:...|.|:..|:|.| |:|    .|...|....:....:|.....|..:|.:::||    .
Zfish   308 DDEFLWKQLSANVLIFLCT-NII----GICTHYPAEVSQRQAFQETRGYIQARLHLQRENQQQER 367

  Fly   251 LLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLE 315
            ||.|:|||.:...::.:|.::.||.         ...|::::.:.|||||.||:..:|.|.:...
Zfish   368 LLLSVLPRHVAMEMKADINAKKEDM---------MFHKIYIQKHDNVSILFADIEGFTSLASQCT 423

  Fly   316 APQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGV 380
            |.:||..|::||..||..|:.|..:|||.|||.|.||:|:|.....||.|||:..::||   :.:
Zfish   424 AQELVMTLNELFARFDKLASENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVDMI---EAI 485

  Fly   381 SSRRE---LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSM 442
            |..||   :::|:|:|:|||.|..|::|..|||||:||.||.:.|.:|:.|..|.:|:::.||..
Zfish   486 SLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQY 550

  Fly   443 LDEHYIFREGTEAAKNDPILQQAGIRTFLV-----------------------SNRLPDAVEPGE 484
            |:..|....|....:| ..|::..|.||||                       ||   :|:.|..
Zfish   551 LNGDYEVEPGFGGERN-AYLKENSIETFLVLGCSQKRKDEKAMMAKMQRTRTNSN---EALVPRW 611

  Fly   485 LDDELSSASINSCRLSYGGYYEEIQIKAQREIMK------EVDQMAVGHCFIEWRRSSSMKKQDF 543
            :.|...|.:.:|......| .:|...|..|...:      |||:. :|.. |:.|....::| |.
Zfish   612 VPDRSFSRTKDSKVFRQMG-IDETSSKDNRGAQEALNPEDEVDEF-LGRA-IDARSIDQLRK-DH 672

  Fly   544 NEEYLFSNQIHLVLGVFRSWKREWEF-HNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILV 607
            .:::|.:         |::...|.:: ..:.|....|    |.|..|....|:.|:...:|..||
Zfish   673 VKKFLLT---------FQTSSLEKKYAKKVDDRFGGY----VACTLLVFCFISFIQIVVFPHTLV 724

  Fly   608 LLGI---LLILL--ILCILAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVRIPLTM 667
            :|||   :.|:|  ||.|.|.|..:     ||.|.:..:         :|::|..|   |...|:
Zfish   725 MLGIYISIFIILANILFICAIYSCV-----KLFPAAMQT---------VSKKIVQS---RTNSTL 772

  Fly   668 V---VLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKSYAECFGP---WT---VTYCVVIVISL 723
            |   .::|:::.:...:||||..||               .:|...   |:   ||.|::..:|.
Zfish   773 VGVFTIILVFISAFVNMFSCDTQKL---------------VDCVAKQLNWSSEMVTPCIIHNMSR 822

  Fly   724 LFV---------VPGCP--------LVIKILA----------GLLILGLHLGTVHLYY------- 754
            ...         .|.||        :::.:||          |.|.|.|.:....|..
Zfish   823 SVADGLSICPNNTPSCPFPEYFSYSVLLTLLACSVFLQISSIGKLALMLLIQLTFLLLVEWPEVA 887

  Fly   755 ------------GFAFERS---------------ETTDLGLKSDYAHTWYLVALFIV-LVLRERH 791
                        ...|..:               ..|.:.||   ..|..::.:|:: |.|..:.
Zfish   888 LFDNADLFVTANALVFNETLQWSNFNTTTEQCTFRVTKVSLK---VMTPVILTVFVLALYLHAQQ 949

  Fly   792 VNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVR-RPHDQLYYENFSKVAV 855
            |....:.::..::...|..::.:|.....:.::.||||..||..:..| |.:|:|||::...|||
Zfish   950 VESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAV 1014

  Fly   856 MFASIENFN-------ADTAG---LRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLE 910
            |||||.||:       |:..|   ||:|:|||..||:::.:.:.| ::||||.:|.|||.|.||.
Zfish  1015 MFASISNFSEFYVELEANNEGVECLRLLNEIIADFDEIISEEKYR-QLEKIKTIGSTYMAASGLN 1078

  Fly   911 TDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFA 975
            ...|              |.|   |.|.:|                             .:.::|
Zfish  1079 DSTY--------------DKE---GRSHIT-----------------------------ALADYA 1097

  Fly   976 LDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTG 1040
            :.|...|..|. .:.|:.:      .:|||::.|.|:|||:|..||.|||||:|||:||||.|||
Zfish  1098 MHLREQMKYIN-EHSFNNF------QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTG 1155

  Fly  1041 LLDNIQVTRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLV 1081
            :.|.||||....:||.....:...||..:|||.|::.||.:
Zfish  1156 VPDRIQVTTDLHQVLHSKGYQLECRGVIKVKGKGEMTTYFL 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/200 (39%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	66/155 (43%)
		CYCc	814..1056	CDD:214485	88/252 (35%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	87/245 (36%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	54/295 (18%)
		Guanylate_cyc	397..570	CDD:306677	69/176 (39%)
		DUF1053	609..696	CDD:310728	19/99 (19%)
		Guanylate_cyc	1004..1197	CDD:306677	87/247 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910