Protein Alignment CG32305 and adcy2b

DIOPT Version :10

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: XP_005170095.1
• Gene: adcy2b / 557902
• ZFINID: ZDB-GENE-060503-69
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1157
• Identity: 330/1157 - (28%)
• Similarity: 525/1157 - (45%)
• Gaps: 241/1157 - (20%)

  Fly    69 VILLLALVKDIILVTMVPYFAVMLFSPFIMLLSMQNNVGMITN--TLISWLMALF---------- 121
            ::.||.:|....|..:..:||        ..|.|:.::..|..  |.::..:|:|
Zfish    94 IVFLLLIVMGACLALLAVFFA--------SGLDMEEHMAFIMTVPTTLAIFLAIFILVCIESVFK 150

  Fly   122 ----LTSMDLVSDLLGTIYSGAAYPTVPC-YDHV-----VLVSVYMTLP-------IAFYQGSSV 169
                |.|:.:...|:...|....:..:.| :|.|     ::..||..||       ||....||.
Zfish   151 KLLRLFSLLIWGCLVAMGYLFMFFGGIICPWDQVSFFLFIVFVVYTMLPFSMRDAVIASVLTSSS 215

  Fly   170 YVLGMVVSIIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQL 234
            :.|  |:||.....:.:|:.|..|:    ||:..|::.. |:..::...:.|..|::........
Zfish   216 HTL--VLSICLSNTSDHMEALVWQI----LANIIIFICG-NVAGAYHKHLMDLALKQTYHDTCNC 273

  Fly   235 VYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSI 299
            :...|..:....::..||.|:||..:.|.::.||..|::..:.:...:......|:::.:.||||
Zfish   274 IKSPIKLEFEKHQQERLLLSLLPAHIARVMKAEIIQRLKGPNFSQAENTNNFHNLYVQRHTNVSI 338

  Fly   300 LVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHAS 364
            |.||:|.:|.|.:.....:||.:|::||..||..|..|..||||.|||.|.||:|:|:....||.
Zfish   339 LYADIVGFTRLASDCSPGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLLDHAK 403

  Fly   365 CCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGL 429
            .||...|:|....:.|.....:|||:|:|||||.|..|:||..|||:|:||.||.:.|.:|:.|:
Zfish   404 NCVKMGLDMCEAIEKVREATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGV 468

  Fly   430 PGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSN-----RLP---DAVEPGELD 486
            ||.||:|..||..|:..|...:|...:: |..|::.||.|:||.|     |.|   .|:.|....
Zfish   469 PGRVHISSVTLEHLNGAYKVEQGNGQSR-DSYLKEHGIVTYLVINPKAEKRSPLLLSAIRPTMYG 532

  Fly   487 DELSSASINSCRLSYGGYYEEIQIKAQREIMKEVDQM------AVG--HCFIEWRRSSSMKK--- 540
            .::.::...:..|...|..:.......|:.|...:.|      .:|  :|.....|:.|.||
Zfish   533 AKMRASVRMTQYLESWGAAKPFANLHHRDSMTNENGMINTRDVPLGQYNCQQRSERTKSQKKRFE 597

  Fly   541 QDFNE-------------EYLFSNQIHLVLGVF--RSWKREWEFHNLPDLMIKYTMLLVLCAGLA 590
            ::.||             ::|.|..|..:...|  ::.::|:....||  ..||   .|.||.|.
Zfish   598 EELNERIIRTIDGINSQKQWLKSEDIQRISLFFHNKALEKEYRATTLP--AFKY---YVTCACLI 657

  Fly   591 IMSINLIEEATYPDILVL-----LGILLILLILCI-LAGYKKLRLQWKKLTPMSQPSCFLSRWLL 649
            ...|.:::....|...||     :..||:.||||| .||:   .|||.|..     ||.:.| |.
Zfish   658 FFCIFIVQVLVLPKTTVLEVSFGMAFLLLALILCICFAGH---ILQWGKAA-----SCTMPR-LP 713

  Fly   650 RISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSC-------DVAKLELSIIEAHL--------- 698
            ..|:.|.:..::|:.|||....|:.||   |||:.       .||...|:|..:.:
Zfish   714 SSSKVITNKPWIRLALTMATTALILVM---AVFNMFFLGEDRMVASTSLNISNSSMDGPYGQITN 775

  Fly   699 -YNEKSYAECFGPWTVTYCVVIVISLLFVVPGCPLVIKILAGLLILGLHLGTVHLY--------- 753
             .|.|.|.    |:.:..|::.:||       |.:.::|...|.:: :.||.|..|
Zfish   776 SSNNKFYL----PYFIYSCILGLIS-------CSVFLRINYELKMI-IMLGAVVAYNIIILQTHA 828

  Fly   754 -----YGFAFERSETTDL-GLKSDYAHTWYLVALFI----VLVLRERHVNYLR-KF---NYFMRV 804
                 |..|..:::..|. |:..| ..|...::|||    :|||..::..|.| .|   |.|.:.
Zfish   829 SILDDYSMALYKTQQPDRPGVLKD-LKTMGSISLFIFFVTLLVLARQNEYYCRLDFLWRNKFKKE 892

  Fly   805 CYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRR-PHDQLYYENFSKVAVMFASIENF----- 863
            |.|   .:|.|.|.  ::::.|:||.|||:.:..|. .::.||::::..|.||||||.:|
Zfish   893 CEE---IETMENLN--RVLLENVLPAHVAEHFLGRNWKNEDLYHQSYDTVCVMFASIPDFKEFYT 952

  Fly   864 --NADTAG---LRILHEIICCFDDLLVDYQTRYK-IEKIKVMGWTYMVACGLETDHYTDFSIDIP 922
              :.:..|   ||:|:|||..||:||  .:.::. :||||.:|.|||.|.||
Zfish   953 ESDVNKEGLECLRLLNEIIADFDELL--SKPKFSGVEKIKTIGSTYMAATGL------------- 1002

  Fly   923 VKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQ--PYAQVQD---VAVLVMTEFALDLLRIM 982
                                            ||:.  .|||..|   :.:..|.|||..|:..:
Zfish  1003 --------------------------------NVTPGLEYAQYHDRQYMHIGTMVEFAFALVGKL 1035

  Fly   983 HDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQV 1047
             |:...:.|:::      .:::||:||.|:|||:|..||.|||||:|||:||||.|||:|..|||
Zfish  1036 -DVINKHSFNDF------RMRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQV 1093

  Fly  1048 TRHTAKVLRQFNIRCNYRGHTEVKGVGKVPTYLVVVDPDLTFQDHDQVSMSM 1099
            |..|..:|:.....|:.||...|||.|.:.|:.|          |.:::.|:
Zfish  1094 TEETNWILQTLGYMCSCRGIINVKGKGDLRTFFV----------HTEMTQSL 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	AcyC	62..451	CDD:441717	122/410 (30%)
		Nucleotidyl_cyc_III	292..445	CDD:448371	70/152 (46%)
		Nucleotidyl_cyc_III	845..1081	CDD:448371	86/251 (34%)
adcy2b	XP_005170095.1	AcyC	97..516	CDD:441717	131/434 (30%)
		Guanylate_cyc	328..512	CDD:425528	80/184 (43%)
		Adcy_cons_dom	542..647	CDD:461877	20/106 (19%)
		Guanylate_cyc	929..1128	CDD:425528	87/262 (33%)