DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and NPR1

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_000897.3	Gene:	NPR1 / 4881	HGNCID:	7943	Length:	1061	Species:	Homo sapiens

Alignment Length:	299	Identity:	85/299 - (28%)
Similarity:	120/299 - (40%)	Gaps:	78/299 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   789 ERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRRPHDQLYYENFSKV 853
            |::.|.|.:.       .||..|...|:.|..:.::..|||..||:..|   ..:.:..|.|..|
Human   821 EQYANNLEEL-------VEERTQAYLEEKRKAEALLYQILPHSVAEQLK---RGETVQAEAFDSV 875

  Fly   854 AVMFASIENFNADTAG------LRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLETD 912
            .:.|:.|..|.|.:|.      :.:|:::..|||.::.::.. ||:|.|   |..|||..||
Human   876 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDV-YKVETI---GDAYMVVSGL--- 933

  Fly   913 HYTDFSIDIPVKQPEADS-EIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFAL 976
                     ||:.....: |:.|                                       .||
Human   934 ---------PVRNGRLHACEVAR---------------------------------------MAL 950

  Fly   977 DLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGL 1041
            .||..:...|..:...|     ...|:|||..|.|.||||||..|.|.::|.|||.||||.|.|.
Human   951 ALLDAVRSFRIRHRPQE-----QLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGE 1010

  Fly  1042 LDNIQVTRHTAKVLRQF-NIRCNYRGHTEVKGVGKVPTY 1079
            ...|.::..|..||.:| ......||..|:||.|||.||
Human  1011 ALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTY 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485
		Nucleotidyl_cyc_III	292..445	CDD:299850
		CYCc	814..1056	CDD:214485	67/248 (27%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	71/243 (29%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:107380
		ANF_receptor	54..414	CDD:279440
		PK_GC-A_B	534..807	CDD:270944
		TyrKc	547..801	CDD:197581
		HNOBA	<816..861	CDD:285003	13/46 (28%)
		CYCc	840..1032	CDD:214485	69/254 (27%)
		Guanylate_cyc	867..1053	CDD:278633	71/243 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900