DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and Adcy1

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_033752.1	Gene:	Adcy1 / 432530	MGIID:	99677	Length:	1118	Species:	Mus musculus

Alignment Length:	1164	Identity:	309/1164 - (26%)
Similarity:	498/1164 - (42%)	Gaps:	281/1164 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LRLELACSRLRELALMSNVVQIIWHVELLMV-------------AHVILLLALVKDIILVTMVPY 87
            ||||.|.: |:.||::|.:...:...|||..             .|.||.|||    .:||.|..
Mouse    53 LRLEQAAT-LKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCILFLAL----FVVTNVRS 112

  Fly    88 FAVMLFSPFIMLLSMQNNVGMITNTLISWLMALFLTSMDLVSDLLGTIYS----------GAAYP 142
            ..|          |....||.         :|||.:   |...||...::          ||...
Mouse   113 LQV----------SQLQQVGQ---------LALFFS---LTFALLCCPFALGGPARSSAGGAMGS 155

  Fly   143 TVPCYDHVVLVSVYMTLPIAFYQGSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYL--------- 198
            |      |....|:..|.:.|..    |.|..|.|::.||:...:...:..|:..|
Mouse   156 T------VAEQGVWQLLLVTFVS----YALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLW 210

  Fly   199 --LASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMI 261
              |.:.|:..|.:|:...|..|:.:...|:|.|.....:...:..:...:|:..||.|:|||.:.
Mouse   211 RTLGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVA 275

  Fly   262 RTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDL 326
            ..::|:.          ..|.:....|::::.:.|||||.||:|.:|.|.:...|.:||::|::|
Mouse   276 MEMKEDF----------LKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNEL 330

  Fly   327 FVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLR 391
            |..||..|..|...|||.|||.|.||:|:......||.|||:..|:||.....|:...|:|:|:|
Mouse   331 FGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMR 395

  Fly   392 IGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAA 456
            :|:|:|.|..|::|..|||:|:||.||.:.|.:|::||||.||:::.||:.|:..|....|....
Mouse   396 VGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHE 460

  Fly   457 KNDPILQQAGIRTFLVSNRLPDAVEPGELDDELSSASINSCRLSYGGY-YEEIQIKAQREIMK-E 519
            :| ..|:...|.||.:.......:.||.:..::..|.    |:.:... |..:|:...|::.| |
Mouse   461 RN-TFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAK----RMKFKTVCYLLVQLMHCRKMFKAE 520

  Fly   520 VDQMAVGHCFIEWR----RSSSMKKQDFNEEYLFSNQIHLVLGV--------------------- 559
            :....|..|..:.:    |::|.|.:  |.....:|.::...|.
Mouse   521 IPFSNVMTCEDDDKRRALRTASEKLR--NRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMAD 583

  Fly   560 -------FRSWKREWEFHNLPDLMIKY-----TMLLVLCAGLAIMSINLIEEATYPDILVLLGIL 612
                   ::..:||.::|.|.|   :|     .:.|:|.|...::.:.:|.::.  .:|:||...
Mouse   584 LNFFTLKYKHVEREQKYHQLQD---EYFTSAVVLALILAALFGLIYLLVIPQSV--AVLLLLVFS 643

  Fly   613 LILLILCILAGYKKL-RLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVM 676
            :..|:.|.|  |..: |:|       ..|.|.              ::.:|..|.:.:::|:|.:
Mouse   644 ICFLVACTL--YLHITRVQ-------CFPGCL--------------TIQIRTALCVFIVVLIYSV 685

  Fly   677 SSQAVFSCDVAKLELSIIEAHLYNEKSYAECFGPW---TVTYCVVIVISL---LFVVPGCP---- 731
            :...|..|                        .||   :.:...::|::.   ..|:|..|
Mouse   686 AQGCVVGC------------------------LPWAWSSQSNSSLVVLAAGGRRTVLPALPCESA 726

  Fly   732 --LVIKILAGLLILGLHLGTVHL-----------YYGFAFERSETTDLG----LKSDYAHTWYLV 779
              .::..|.|.|.|.:.|....|           .|....|.|..|.:|    ....|.....::
Mouse   727 HHALLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAIL 791

  Fly   780 ALFIVLVLRERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRRPHD- 843
            .....|.|..|.|:...:.:|......||.....:......|.|:.|:||.||||.:.:..|.:
Mouse   792 LFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNM 856

  Fly   844 QLYYENFSKVAVMFASIENFN-------ADTAG---LRILHEIICCFDDLL-VDYQTRYK-IEKI 896
            .|||:::|:|.||||||.|||       .:..|   ||:|:|||..||:|: .|:   || :|||
Mouse   857 DLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDF---YKDLEKI 918

  Fly   897 KVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYA 961
            |.:|.|||.|.||               .|.|.:   |....::.|
Mouse   919 KTIGSTYMAAVGL---------------APTAGT---RAKKSISSH------------------- 946

  Fly   962 QVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIW 1026
                  :..:.:||:|:..::.:|.|    ..|:.|:   |::||:.|.|:|||:|..:|.||||
Mouse   947 ------LCTLADFAIDMFDVLDEINY----QSYNDFV---LRVGINVGPVVAGVIGARRPQYDIW 998

  Fly  1027 GHTVNMASRMSSTGLLDNIQVTRHTAKVLRQFNIRCNY----RGHTEVKGVGKVPTYLV 1081
            |:|||:||||.|||:...||||....::|:    ||:|    ||...|||.|::.||.:
Mouse   999 GNTVNVASRMDSTGVQGRIQVTEEVHRLLK----RCSYQFVCRGKVSVKGKGEMLTYFL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	78/197 (40%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	68/152 (45%)
		CYCc	814..1056	CDD:214485	88/254 (35%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	90/251 (36%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		AC_N	<158..291	CDD:292831	29/146 (20%)
		CYCc	257..452	CDD:214485	78/204 (38%)
		Guanylate_cyc	293..475	CDD:278633	75/182 (41%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		5/30 (17%)
		CYCc	825..1036	CDD:214485	92/267 (34%)
		Guanylate_cyc	858..1055	CDD:278633	90/253 (36%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		9/26 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810