DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG32305 and GUCY2D

DIOPT Version :9

Sequence 1:NP_728725.2 Gene:CG32305 / 317967 FlyBaseID:FBgn0052305 Length:1164 Species:Drosophila melanogaster
Sequence 2:NP_000171.1 Gene:GUCY2D / 3000 HGNCID:4689 Length:1103 Species:Homo sapiens


Alignment Length:776 Identity:167/776 - (21%)
Similarity:274/776 - (35%) Gaps:264/776 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 GVHSGEVFAG---IIGHTKWQFDIWSKDVDITNRLESSGLPG--LVH-VSQRTLSML-------- 443
            |:..|.||.|   ::|                     .||.|  |.| |..|.|.|.        
Human   460 GLEPGLVFLGFLLVVG---------------------MGLAGAFLAHYVRHRLLHMQMVSGPNKI 503

  Fly   444 -----DEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGELDDELSSASINSCRLSYGG 503
                 |..::...|..:.|   :.|  |.|:.|.:..:.| :..|. ...|.|.:|        |
Human   504 ILTVDDITFLHPHGGTSRK---VAQ--GSRSSLGARSMSD-IRSGP-SQHLDSPNI--------G 553

  Fly   504 YYEEIQIKAQREIMKEV--DQMAVGHCFIEWRRSSSMKK-QDFNEEYLFSNQIHLVLGVFRSWKR 565
            .||     ..|..:|:.  ||    |..|.....::..| |:...|     .:.|.||:|.:...
Human   554 VYE-----GDRVWLKKFPGDQ----HIAIRPATKTAFSKLQELRHE-----NVALYLGLFLARGA 604

  Fly   566 E-----WEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEAT---YPDILVLLGILL-----ILLI 617
            |     ||                  ..||::|    |..|   ..|:|....|.|     ..|:
Human   605 EGPAALWE------------------GNLAVVS----EHCTRGSLQDLLAQREIKLDWMFKSSLL 647

  Fly   618 LCILAGYKKLRLQWKKLTPMSQPSCFL-SRWLLRISE-----------------RIEDSLF---- 660
            |.::.|.:.|..:......:...:|.: .|::|:|::                 |.||.|:    
Human   648 LDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPE 712

  Fly   661 -VRIP-------LTMVVLLLLYVMSSQAVFSCDVAKLELSIIEAHLYNEKSYAECFGPWTVTYCV 717
             :|.|       |...|..|..:|......|...|.|||:..|. :...:|......|       
Human   713 LLRDPALERRGTLAGDVFSLAIIMQEVVCRSAPYAMLELTPEEV-VQRVRSPPPLCRP------- 769

  Fly   718 VIVISLLFVVPGCPLVIKILAGLLILGLHLGTVHLYYGFAFERSETTDLGLKSDYAHTWYLVALF 782
              ::|:......|.|::|....                   |:.|     |:....||:.|.   
Human   770 --LVSMDQAPVECILLMKQCWA-------------------EQPE-----LRPSMDHTFDLF--- 805

  Fly   783 IVLVLRERHVNYLRKFNY---FMRVCYEEAHQQTD---EKLRSIKI-------IMANILPTHVAQ 834
                   :::|..||.|.   .:|:..:.:....|   |:...:::       ::..:||..||:
Human   806 -------KNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAE 863

  Fly   835 VYKVRRPHDQLYYENFSKVAVMFASIENFNADTA------GLRILHEIICCFDDLLVDYQTRYKI 893
            ..|...|.:..|:|   :|.:.|:.|..|...:|      .:.:|:::...||.::..:.. ||:
Human   864 ALKTGTPVEPEYFE---QVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDV-YKV 924

  Fly   894 EKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQ 958
            |.|   |..||||.||                |:.                          |..:
Human   925 ETI---GDAYMVASGL----------------PQR--------------------------NGQR 944

  Fly   959 PYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHY 1023
            ..|::.::::.:::......:|.|.::...             ::||:..|..:||||||:.|.|
Human   945 HAAEIANMSLDILSAVGTFRMRHMPEVPVR-------------IRIGLHSGPCVAGVVGLTMPRY 996

  Fly  1024 DIWGHTVNMASRMSSTGLLDNIQVTRHTAKVLRQFN--IRCNYRGHTEVKGVGKVPTYLVV 1082
            .::|.|||.||||.||||...|.|...|..:||..:  .:...||.||:||.|...|:.:|
Human   997 CLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLV 1057

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG32305NP_728725.2 CYCc 251..449 CDD:214485 16/74 (22%)
Nucleotidyl_cyc_III 292..445 CDD:299850 15/70 (21%)
CYCc 814..1056 CDD:214485 60/257 (23%)
Nucleotidyl_cyc_III 845..1081 CDD:299850 62/243 (26%)
GUCY2DNP_000171.1 PBP1_sensory_GC_DEF-like 55..431 CDD:380594
PK_GC-2D 536..811 CDD:270945 70/364 (19%)
HNOBA <820..865 CDD:369471 7/44 (16%)
CYCc 846..1036 CDD:214485 60/251 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1065..1103
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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