Protein Alignment CG32305 and Adcy6

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_001257714.1
• Gene: Adcy6 / 25289
• RGDID: 2035
• Length: 1180
• Species: Rattus norvegicus
• Alignment Length: 1173
• Identity: 292/1173 - (24%)
• Similarity: 497/1173 - (42%)
• Gaps: 319/1173 - (27%)

  Fly    64 LMVAHVILLLALVKDIILVTMVP---YFAVMLFSP--FIMLLSMQNNVGMITNTLISWLMALFLT 123
            |::|.::||:|::........:|   |.|::..:.  |::|:.:.|......:::  |:::.
  Rat   166 LLMAVLVLLMAVLLTFHAAPALPQPAYVALLTCASVLFVVLMVVCNRHSFRQDSM--WVVSY--- 225

  Fly   124 SMDLVSDLLGTIYSG---AAYPTVP-----CYDHVVLVSVYMTLPIAFYQGSSVYVLGMVVSIIY 180
               :|..:|..:..|   ||.|..|     |....|.:: |..|||..   .:..:.|:.:|.::
  Rat   226 ---VVLGILAAVQVGGALAANPRSPSAGLWCPVFFVYIT-YTLLPIRM---RAAVLSGLGLSTLH 283

  Fly   181 IGYAFYMQYLNDQVSF---YLLASYAIYLFTLNLIFSFFTIIRDYGLRRA-------ILSRYQLV 235
            :..|:   :||:...|   .|.|:..::|.| |.|........:...|:|       |.:|..|.
  Rat   284 LILAW---HLNNGDPFLWKQLGANVVLFLCT-NAIGVCTHYPAEVSQRQAFQETRGYIQARLHLQ 344

  Fly   236 YQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSIL 300
            ::|       :::..||.|:||:.:...::|:|.::.||.         ...|::::.:.|||||
  Rat   345 HEN-------RQQERLLLSVLPQHVAMEMKEDINTKKEDM---------MFHKIYIQKHDNVSIL 393

  Fly   301 VADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASC 365
            .||:..:|.|.:...|.:||..|::||..||..|..|..:|||.|||.|.||:|:|.....||.|
  Rat   394 FADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHC 458

  Fly   366 CVDQALEMIHITQGVSSRRE---LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESS 427
            ||:..::||   :.:|..||   :::|:|:|:|||.|..|::|..|||||:||.||.:.|.:|:.
  Rat   459 CVEMGVDMI---EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAG 520

  Fly   428 GLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLV-------------------- 472
            |..|.:|:::.||..|:..|....|....:|..:.:|. |.|||:
  Rat   521 GRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQC-IETFLILGASQKRKEEKAMLVKLQRT 584

  Fly   473 -------------------------------------SNR-LPDAVEPGELDDELSSASINSCRL 499
                                                 .|| ..||:.|.:..||....:|::
  Rat   585 RANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDDSSKENRGAQDALNPEDEVDEFLGRAIDA--- 646

  Fly   500 SYGGYYEEIQIKAQREIMKEVDQMAVGHCFIEWRR-SSSMKKQDFNEEYLFSNQIHLVLGVFRSW 563
                              :.:||:...|.    || ..:.:::|..::|  |.::....|.:
  Rat   647 ------------------RSIDQLRKDHV----RRFLLTFQREDLEKKY--SRKVDPRFGAY--- 684

  Fly   564 KREWEFHNLPDLMIKYTMLLVLCAGLAIMSINLIEEATYPDILVLLGI-------LLILLILCIL 621
                                |.||.|....|..|:...:|...::|||       ||:.:::|.:
  Rat   685 --------------------VACALLVFCFICFIQFLVFPHSALILGIYAGIFLLLLVTVLICAV 729

  Fly   622 AGYKKLRLQWKKLTPMSQPSC--FLSRWLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVFSC 684
            .                  ||  |....|.|:|..|..|......:.:..:||:::.:...:|:|
  Rat   730 C------------------SCGSFFPNALQRLSRSIVRSRVHSTAVGVFSVLLVFISAIANMFTC 776

  Fly   685 ------------------DVAKLELSIIEAHLYNEKSYAECFGPWTVTYCVVIVISLLFVVPGCP 731
                              ||....|..:...|..|....|...| |.::....|.|:|..:....
  Rat   777 SHTPLRTCAARMLNLTPSDVTACHLRQLNYSLGLEAPLCEGTAP-TCSFPEYFVGSVLLSLLASS 840

  Fly   732 LVIKILA-GLLILGLHLGTVHL--------------------YYGFAFERSETTD---------L 766
            :.:.|.: |.|::...||.::|                    .:|.| ..:||.|         :
  Rat   841 VFLHISSIGKLVMTFVLGFIYLLLLLLGPPATIFDNYDLLLSVHGLA-SSNETFDGLDCPAVGRV 904

  Fly   767 GLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCYEEAHQQTDEKLRSIKIIMANILPTH 831
            .||  |.....|:...:.|.|..:.|....:.::..::......::.:|.....:.::.||||..
  Rat   905 ALK--YMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKD 967

  Fly   832 VAQVYKVR-RPHDQLYYENFSKVAVMFASIENFN-------ADTAG---LRILHEIICCFDDLLV 885
            ||..:..| |.:|:|||::...||||||||.||:       |:..|   ||:|:|||..||:::.
  Rat   968 VAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIIS 1032

  Fly   886 DYQTRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDE 950
            :.:.| ::||||.:|.|||.|.||....|
  Rat  1033 EERFR-QLEKIKTIGSTYMAASGLNASTY------------------------------------ 1060

  Fly   951 MSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVFSEYDTFLTGSLKIGISHGSVMAGV 1015
               |.|.:.:       :..:.::|:.|:..|..|. .:.|:.:      .:|||::.|.|:|||
  Rat  1061 ---DQVGRSH-------ITALADYAMRLMEQMKHIN-EHSFNNF------QMKIGLNMGPVVAGV 1108

  Fly  1016 VGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVL--RQFNIRCNYRGHTEVKGVGKVPT 1078
            :|..||.|||||:|||::|||.|||:.|.||||....:||  :.:.:.|  ||..:|||.|::.|
  Rat  1109 IGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLEC--RGVVKVKGKGEMTT 1171

  Fly  1079 YLV 1081
            |.:
  Rat  1172 YFL 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/200 (39%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	66/155 (43%)
		CYCc	814..1056	CDD:214485	85/254 (33%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	84/247 (34%)
Adcy6	NP_001257714.1	AC_N	28..380	CDD:292831	52/245 (21%)
		CYCc	346..541	CDD:214485	77/213 (36%)
		Guanylate_cyc	382..566	CDD:278633	74/187 (40%)
		DUF1053	594..680	CDD:283888	16/112 (14%)
		CYCc	956..1157	CDD:214485	84/254 (33%)
		Guanylate_cyc	982..1176	CDD:278633	84/249 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010