DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	275	Identity:	67/275 - (24%)
Similarity:	123/275 - (44%)	Gaps:	60/275 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 ILSRYQLVYQNIVYQLVMKKE----------------NGLLESILPRKMIRTLQEEICSRIEDQD 276
            :|::.:|....:..||..|||                ..||.::||..:...|:|.
  Rat   401 LLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEG--------- 456

  Fly   277 KNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMR 341
                      ||:....:...:||.:|:|.:|::....|..|:|.:|:.::..||...:.:...:
  Rat   457 ----------RKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTSVHDVYK 511

  Fly   342 IKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELD------INLRIGVHSGEVF 400
            ::.:||:|..|.|:|....:||....:.||.|     .:|::..::      |.:|:|:|:|.|.
  Rat   512 VETIGDAYMVVGGVPVPVESHAQRVANFALGM-----RISAKEVMNPVTGEPIQIRVGIHTGPVL 571

  Fly   401 AGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVS---QRTLSMLDEHYIFREGTEAAKNDPI- 461
            ||::|....::.::...|:..:|:||.|||..||:|   .|.|.        .:|.|..:...|
  Rat   572 AGVVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAHRALK--------NKGFEIVRRGEIE 628

  Fly   462 LQQAGIRT--FLVSN 474
            ::..|..|  ||:.|
  Rat   629 VKGKGKMTTYFLIQN 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	52/206 (25%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	44/161 (27%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002
		HNOBA	267..453	CDD:285003	11/51 (22%)
		CYCc	432..622	CDD:214485	54/221 (24%)
		Guanylate_cyc	459..642	CDD:278633	51/195 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810