DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Gucy1b1

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_036901.2	Gene:	Gucy1b1 / 25202	RGDID:	2769	Length:	619	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	74/297 - (24%)
Similarity:	132/297 - (44%)	Gaps:	41/297 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 GSSVYVLGMVVSIIYIGYAFYMQYLNDQVSFYL--LASYAIYL-------FTLNLIFSFFTIIRD 221
            |:.:..|.:...:||:..|..:.:|.......|  |....:||       .|.:|:........:
  Rat   298 GAEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREE 362

  Fly   222 YGLRR---AILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSK 283
            |.|.:   .:..|.||..:.:..:  .||.:.||.|:||..:...|:.          |...|:|
  Rat   363 YKLTQELEILTDRLQLTLRALEDE--KKKTDTLLYSVLPPSVANELRH----------KRPVPAK 415

  Fly   284 AGLRKLFLEPYPNVSILVADMVNYTHLTTTLE----APQLVEILHDLFVNFDLAANRNR---AMR 341
            .         |.||:||.:.:|.:....:...    |.::|.:|:||:..||...:..:   ..:
  Rat   416 R---------YDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYK 471

  Fly   342 IKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGH 406
            ::.:||.|..|:|:|.....||......||:|:.|...|....| .:.:.||:|:|||..|:||.
  Rat   472 VETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGE-SVQITIGIHTGEVVTGVIGQ 535

  Fly   407 TKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSML 443
            ...::.::...|::|:|.|::|..|.::||:.|...|
  Rat   536 RMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	55/200 (28%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	46/159 (29%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Gucy1b1	NP_036901.2	HNOB	2..166	CDD:285002
		HNOBA	207..406	CDD:285003	24/109 (22%)
		CYCc	385..584	CDD:214485	57/210 (27%)
		Guanylate_cyc	412..605	CDD:278633	48/171 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900