DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	323	Identity:	75/323 - (23%)
Similarity:	139/323 - (43%)	Gaps:	70/323 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 ILSRYQLVYQNIVYQLVMKKE----------------NGLLESILPRKMIRTLQEEICSRIEDQD 276
            :|::.:|....:..||..|||                ..||.::||..:...|:|.
Mouse   514 LLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETLLYAMLPEHVANQLKEG--------- 569

  Fly   277 KNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMR 341
                      :|:....:...:||.:|:|.:|::....|..|:|.:|:.::..||...|.:...:
Mouse   570 ----------KKVAAGEFETCTILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTNIHDVYK 624

  Fly   342 IKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVSSRRELD------INLRIGVHSGEVF 400
            ::.:||:|..|.|:|....:||....:.||.|     .:|::..::      |.:|:|:|:|.|.
Mouse   625 VETIGDAYMVVGGVPVPVESHAQRVANFALGM-----RISAKEVMNPVTGEPIQIRVGIHTGPVL 684

  Fly   401 AGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPI-LQQ 464
            ||::|....::.::...|:..:|:||.|||..||:|......|:     .:|.|......| ::.
Mouse   685 AGVVGDKMPRYCLFGDTVNTASRMESHGLPNKVHLSPTAHRALE-----NKGFEIVTRGEIEVKG 744

  Fly   465 AGIRT--FLVSNRLPDAVE----PGELDDELSSASINSCRLSYGGYYEEIQIKAQREIMKEVD 521
            .|..|  ||:.|.....||    |..|.|...:::..:            |:|..|.::..:|
Mouse   745 KGKMTTYFLIRNLNATEVEIMGRPSALADGKEASTPRN------------QVKKPRAVLSNMD 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	51/203 (25%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	44/158 (28%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167
		HNOBA	380..566	CDD:400168	11/51 (22%)
		Guanylate_cyc	572..754	CDD:306677	50/191 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810