DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and PHLPP1

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	1143	Identity:	205/1143 - (17%)
Similarity:	355/1143 - (31%)	Gaps:	435/1143 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 YIGYAFYMQYL----------NDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQL 234
            ||.:..:.:||          :.::|...|:..::.....||.:|                 ..|
Human   615 YICFDTFTEYLRWLRQVSKVASQRISSVDLSCCSLEHLPANLFYS-----------------QDL 662

  Fly   235 VYQNIVYQLVMKKENGLLES-ILPRKMIRTLQEEICSRIEDQDKNFTPSKA-GLRKLFLEPYPNV 297
            .:.|:       |:|.|.:: .||           .:|..::.:.||..|: .|....|..:|
Human   663 THLNL-------KQNFLRQNPSLP-----------AARGLNELQRFTKLKSLNLSNNHLGDFP-- 707

  Fly   298 SILVADMVNYTHLTTTLEA----PQLVEILHDL--FV---NF--DLAANRNRAMRIKFLGDSYNC 351
             :.|..:.....|..:..|    |..|.::|:|  |:   ||  .|.|......::.:||.|:|.
Human   708 -LAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAELENMKQLSYLGLSFNE 771

  Fly   352 VAGIPNYFPAHAS----C----CVD----QAL-EMIHITQGVSSRRELDINLRIGVHSGEVFAGI 403
            ...||.......:    |    ||:    ||| :|.||       :.:|:.|
Human   772 FTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHI-------KHVDLRL------------- 816

  Fly   404 IGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIR 468
                           ::..:|.:..:..|.||:|     ||
Human   817 ---------------NVIRKLIADEVDFLQHVTQ-----LD------------------------ 837

  Fly   469 TFLVSNRLPDAVEPGELDDEL-SSASINSCR------LSYGGYYEEIQIKAQREIMKEVDQMAVG 526
              |..|:|      |:||..: ::..:..|.      |...||:    :||......|:.|:.|
Human   838 --LRDNKL------GDLDAMIFNNIEVLHCERNQLVTLDICGYF----LKALYASSNELVQLDV- 889

  Fly   527 HCFIEWRRSSSMKKQDFNEEYLFSNQIHLVLGVFRSWKREWEFHNLPDLMIKYTMLLVLCAGLAI 591
                                |...|.:. .:.|.|:     ...|:|:.:.:...|.||..|
Human   890 --------------------YPVPNYLS-YMDVSRN-----RLENVPEWVCESRKLEVLDIG--- 925

  Fly   592 MSINLIEEATYPDILVLLGILLILLILC------ILAGYKKLRLQWKKLTPMSQPSCFLSRWLLR 650
              .|.|.|             |...:.|      :|||:.:                     |.|
Human   926 --HNQICE-------------LPARLFCNSSLRKLLAGHNQ---------------------LAR 954

  Fly   651 ISERIEDSLFVRIPLTMVVLL-----LLYVMSSQAVFSCDVAKLEL-----------SII-EAHL 698
            :.||:|.:....:.:....||     ||....|....:....|||.           ||: |.:|
Human   955 LPERLERTSVEVLDVQHNQLLELPPNLLMKADSLRFLNASANKLESLPPATLSEETNSILQELYL 1019

  Fly   699 YNEKSYAECFGPWTVTYCVVIVISLLFVVPGCPLVIKILAGLLILGLHLGTVHLYYG-------- 755
            .|.....:|             :.||   .|.|              ||..:|:.|.
Human  1020 TNNSLTDKC-------------VPLL---TGHP--------------HLKILHMAYNRLQSFPAS 1054

  Fly   756 --FAFERSETTDL-GLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRV----CYEEAHQQT 813
              ...|..|..|| |.|.....|..:....:..|:  .|.|.:..|...|::    |.:.:..:.
Human  1055 KMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVI--AHSNCIEVFPEVMQLPEIKCVDLSCNEL 1117

  Fly   814 DE---------KLRSIKI--------------IMANILPTHVAQVYKVRRP-------------H 842
            .|         ||:.:.:              ::.||      :.:|:.:|             |
Human  1118 SEVTLPENLPPKLQELDLTGNPRLVLDHKTLELLNNI------RCFKIDQPSTGDASGAPAVWSH 1176

  Fly   843 DQLYYENF---SKVAVMFASIENFNADTAGL----------RILHEIICCFDDLLVDYQTRYKIE 894
            .  |.|..   :|:.|...|:.||..:...|          .:.:.:.|...|:|.:...:.|.|
Human  1177 G--YTEASGVKNKLCVAALSVNNFCDNREALYGVFDGDRNVEVPYLLQCTMSDILAEELQKTKNE 1239

  Fly   895 KIKVMGWTYMVACGLETDHYTDFSIDIPVKQPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQP 959
            :      .|||            :..|.:::....:..:.|.:.:..|.  ..|....|.:.:..
Human  1240 E------EYMV------------NTFIVMQRKLGTAGQKLGGAAVLCHI--KHDPVDPGGSFTLT 1284

  Fly   960 YAQV-QDVAVLVMTEFALDLLRIMHDIRYNYVFS---------EYDTFLTGSLKI-GISHGSVMA 1013
            .|.| :...||......|.|.|       :|:.|         ::...:|...|: |::..:.:.
Human  1285 SANVGKCQTVLCRNGKPLPLSR-------SYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRIL 1342

  Fly  1014 GVVGL-----SKPHYDIWGHTVNMASR-----MSSTGLLDNIQV------TRHTAKVLRQFNIRC 1062
            |...|     .:||.    .:|.:..:     :.|.||.|::.|      .|:....|......|
Human  1343 GYTFLHPSVVPRPHV----QSVLLTPQDEFFILGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLC 1403

  Fly  1063 ----NYRGHTEVKGV-------------------GKVPTYLVVVDP---DLTFQDHDQVSMSMKD 1101
                :|..|..:..|                   |.||.....:.|   ::..:|.....:.:..
Human  1404 TLAQSYGCHDSISAVVVQLSVTEDSFCCCELSAGGAVPPPSPGIFPPSVNMVIKDRPSDGLGVPS 1468

  Fly  1102 SKSWVIDTLSLSFTPSFVPPK-SSTSDEEEAEGELEEN 1138
            |.|.:...:|...:.|.:..: .||:.:|...|.|.||
Human  1469 SSSGMASEISSELSTSEMSSEVGSTASDEPPPGALSEN 1506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	46/223 (21%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	36/176 (20%)
		CYCc	814..1056	CDD:214485	52/317 (16%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	52/298 (17%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	2/21 (10%)
		PP2Cc	1168..1420	CDD:214625	50/284 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510		12/49 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131	4/15 (27%)
		PH	555..636	CDD:278594	4/20 (20%)
		LRR_RI	625..929	CDD:238064	82/449 (18%)
		LRR_8	638..703	CDD:290566	17/99 (17%)
		LRR 1	638..659		4/20 (20%)
		leucine-rich repeat	641..661	CDD:275380	4/36 (11%)
		LRR 2	661..682		7/38 (18%)
		leucine-rich repeat	662..692	CDD:275380	9/47 (19%)
		LRR 3	692..712		5/22 (23%)
		leucine-rich repeat	693..738	CDD:275380	9/47 (19%)
		LRR_8	714..770	CDD:290566	14/55 (25%)
		LRR 4	715..736		4/20 (20%)
		LRR 5	738..760		6/21 (29%)
		leucine-rich repeat	739..761	CDD:275380	6/21 (29%)
		LRR 6	761..783		6/21 (29%)
		leucine-rich repeat	762..784	CDD:275380	6/21 (29%)
		LRR 7	784..804		5/19 (26%)
		leucine-rich repeat	785..808	CDD:275380	7/22 (32%)
		LRR 8	808..831		5/57 (9%)
		leucine-rich repeat	810..832	CDD:275380	4/49 (8%)
		LRR_RI	814..1074	CDD:238064	74/424 (17%)
		LRR 9	832..853		11/57 (19%)
		leucine-rich repeat	833..853	CDD:275380	10/56 (18%)
		leucine-rich repeat	854..895	CDD:275380	10/65 (15%)
		LRR 10	873..894		6/45 (13%)
		LRR 11	895..916		4/26 (15%)
		leucine-rich repeat	896..918	CDD:275380	4/27 (15%)
		LRR 12	918..939		8/38 (21%)
		leucine-rich repeat	919..941	CDD:275380	9/39 (23%)
		LRR 13	941..962		8/41 (20%)
		leucine-rich repeat	942..963	CDD:275380	8/41 (20%)
		LRR_8	962..1024	CDD:290566	13/61 (21%)
		LRR 14	963..984		4/20 (20%)
		leucine-rich repeat	964..987	CDD:275380	4/22 (18%)
		LRR 15	987..1008		4/20 (20%)
		leucine-rich repeat	988..1011	CDD:275380	3/22 (14%)
		LRR 16	1013..1033		7/35 (20%)
		LRR_8	1014..1072	CDD:290566	17/87 (20%)
		leucine-rich repeat	1014..1037	CDD:275380	8/52 (15%)
		LRR 17	1037..1058		4/20 (20%)
		leucine-rich repeat	1038..1061	CDD:275380	3/22 (14%)
		LRR 18	1061..1082		6/20 (30%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		22/138 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900