DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and PHLPP2

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	611	Identity:	126/611 - (20%)
Similarity:	204/611 - (33%)	Gaps:	206/611 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 DLEWRHLK--------------------NKCQNLRLELACS---------RLRELALMSNVVQII 58
            ||...|||                    |:..:|.|...||         :||||.|....::.:
Human   421 DLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTL 485

  Fly    59 W-------HVELLMVAHVILLLALVKDIILVTMVPYFAVMLFSPFIMLLSMQNNVGMITNTLISW 116
            :       .|.:..|..::..|.|.::  |:..||.:|..  :..|.:|.:..|       |::.
Human   486 YASSNRLTAVNVYPVPSLLTFLDLSRN--LLECVPDWACE--AKKIEVLDVSYN-------LLTE 539

  Fly   117 LMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHV----VLVSVYMTLPIAFYQGSSVYVLGMVVS 177
            :....|:|:.|...:||             ::||    .||. ::.|.:...|.:::..|...:
Human   540 VPVRILSSLSLRKLMLG-------------HNHVQNLPTLVE-HIPLEVLDLQHNALTRLPDTL- 589

  Fly   178 IIYIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQ 242
               ...|..::|||...:            :|..:.|..|       ....||..||:|..
Human   590 ---FSKALNLRYLNASAN------------SLESLPSACT-------GEESLSMLQLLYLT---- 628

  Fly   243 LVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKL-----------FLEPYP- 295
                 .|.|.:..:| .::..|...|.....:|.:.|..||  |.||           .|:..|
Human   629 -----NNLLTDQCIP-VLVGHLHLRILHLANNQLQTFPASK--LNKLEQLEELNLSGNKLKTIPT 685

  Fly   296 ------NVSILVADMVNYTHLTTTLEAPQ----------LVEI---------LHDLFVNFDLAAN 335
                  .:..|||...|.:.....|:.||          |.||         |.||    ||..|
Human   686 TIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDL----DLTGN 746

  Fly   336 RNRAMRIKFLGDSYNCVAGI---PNYFPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSG 397
            .|..:..|.| |.::.:..:   ....|.     .|..:.....:.|::........|.:...:.
Human   747 TNLVLEHKTL-DIFSHITTLKIDQKPLPT-----TDSTVTSTFWSHGLAEMAGQRNKLCVSALAM 805

  Fly   398 EVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPIL 462
            :.||..:|.....||        .:|.|.  ||.|:.     .:|.|   :..|..:.:.||.:.
Human   806 DSFAEGVGAVYGMFD--------GDRNEE--LPRLLQ-----CTMAD---VLLEEVQQSTNDTVF 852

  Fly   463 QQAGIRTFLVSNR------------------LPDAVEPGELDDELSSASINSCR--LSYGGY--- 504
            .   ..|||||:|                  .||..:|.. ...|:.|::.:|:  |..||.
Human   853 M---ANTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPAS-SFSLTVANVGTCQAVLCRGGKPVP 913

  Fly   505 ----------YEEIQ-IKAQREIMKE 519
                      .||.| :|.|:.|:.|
Human   914 LSKVFSLEQDPEEAQRVKDQKAIITE 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	49/237 (21%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	36/181 (20%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131
		LRR 1	250..271
		leucine-rich repeat	253..273	CDD:275380
		LRR 2	273..296
		leucine-rich repeat	274..300	CDD:275380
		LRR 3	300..321
		leucine-rich repeat	301..323	CDD:275380
		LRR_RI	313..606	CDD:238064	43/225 (19%)
		LRR_8	322..380	CDD:290566
		LRR 4	323..344
		leucine-rich repeat	324..346	CDD:275380
		LRR 5	346..368
		leucine-rich repeat	347..369	CDD:275380
		LRR 6	369..390
		leucine-rich repeat	370..416	CDD:275380
		LRR 7	392..412
		LRR 8	416..439		5/17 (29%)
		leucine-rich repeat	418..440	CDD:275380	5/18 (28%)
		LRR 9	440..460		3/19 (16%)
		leucine-rich repeat	442..461	CDD:275380	3/18 (17%)
		LRR 10	461..480		6/18 (33%)
		leucine-rich repeat	462..481	CDD:275380	5/18 (28%)
		LRR 11	481..502		2/20 (10%)
		leucine-rich repeat	482..503	CDD:275380	2/20 (10%)
		LRR 12	503..524		6/24 (25%)
		leucine-rich repeat	504..526	CDD:275380	6/25 (24%)
		LRR 13	526..547		5/27 (19%)
		leucine-rich repeat	527..549	CDD:275380	6/28 (21%)
		LRR_8	549..606	CDD:290566	14/86 (16%)
		LRR 14	549..570		7/34 (21%)
		leucine-rich repeat	550..565	CDD:275380	5/27 (19%)
		LRR 15	571..592		3/24 (13%)
		leucine-rich repeat	572..595	CDD:275380	4/26 (15%)
		LRR 16	595..616		6/39 (15%)
		leucine-rich repeat	596..645	CDD:275380	14/77 (18%)
		LRR 17	621..644		6/32 (19%)
		LRR_8	645..703	CDD:290566	13/59 (22%)
		LRR_4	645..685	CDD:289563	9/41 (22%)
		LRR 18	645..666		6/22 (27%)
		leucine-rich repeat	646..669	CDD:275380	8/24 (33%)
		LRR 19	669..690		2/20 (10%)
		leucine-rich repeat	670..692	CDD:275380	2/21 (10%)
		LRR 20	692..713		5/20 (25%)
		leucine-rich repeat	693..714	CDD:275380	5/20 (25%)
		LRR 21	714..735		4/20 (20%)
		leucine-rich repeat	715..734	CDD:275380	3/18 (17%)
		LRR 22	737..758		9/25 (36%)
		leucine-rich repeat	738..764	CDD:275380	10/30 (33%)
		PP2Cc	784..1033	CDD:238083	39/178 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900