Protein Alignment CG32305 and Adcy5

DIOPT Version :9

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_001012783.3
• Gene: Adcy5 / 224129
• MGIID: 99673
• Length: 1262
• Species: Mus musculus
• Alignment Length: 1137
• Identity: 294/1137 - (25%)
• Similarity: 504/1137 - (44%)
• Gaps: 228/1137 - (20%)

  Fly    63 LLMVAHVILLLALVKDIILVTMVP----YFAVMLFSPFIMLLSM---------QNNVGMITNTLI 114
            |.|:..|::|:.||.........|    |.||:..:..::|:..         |:::|:....||
Mouse   243 LTMLMAVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALI 307

  Fly   115 SWLMALFLTSMDLVSDLLGTIYSGAAYPTVPCYDHVVLVSVYMTLPIAFYQGSSVYVLGMVVSII 179
            :.::|:.:..:.|......   |...:.||     ..:.::|..||:..   .:..:.|:::|.:
Mouse   308 AVVLAVQVVGLLLPQPRSA---SEGIWWTV-----FFIYTIYTLLPVRM---RAAVLSGVLLSAL 361

  Fly   180 YIGYAFYMQYLNDQVSFYLLASYAIYLFTLNLIFSFFTII-------RDYGLRRAILSRYQLVYQ 237
            ::..:.   :.|.|..|.|.     .|.:..||||...|:       .:...|:|.....:.:..
Mouse   362 HLAISL---HTNSQDQFLLK-----QLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQA 418

  Fly   238 NIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVA 302
            .:..|...:::..||.|:|||.:...::.:|.::.||.         ...|::::.:.|||||.|
Mouse   419 RLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDM---------MFHKIYIQKHDNVSILFA 474

  Fly   303 DMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCV 367
            |:..:|.|.:...|.:||..|::||..||..|..|..:|||.|||.|.||:|:|.....||.|||
Mouse   475 DIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCV 539

  Fly   368 DQALEMIHITQGVSSRRE---LDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGL 429
            :..::||   :.:|..||   :::|:|:|:|||.|..|::|..|||||:||.||.:.|.:|:.|.
Mouse   540 EMGMDMI---EAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 601

  Fly   430 PGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGELDDELSSASI 494
            .|.:|:::.||:.|:..|....|....:| ..|::..|.|||:.:......|...:..:::....
Mouse   602 AGRIHITKATLNYLNGDYEVEPGCGGDRN-AYLKEHSIETFLILSCTQKRKEEKAMIAKMNRQRT 665

  Fly   495 NSCRLS---YGG---YYEEIQIKAQREIMKEVDQMAVGHCFIEWRRSSSMKKQDFNE-------- 545
            ||...:   :|.   :|..:   ...::.||:.:|.......:..:.|:..:.:.:|
Mouse   666 NSIGHNPPHWGAERPFYNHL---GGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDA 727

  Fly   546 ---EYLFSNQIHLVLGVFRSWKREWEFHNLPDLMIKYTMLL-------VLCAGLAIMSINLIEEA 600
               :.|.|..:...|..||.          |||..||:..:       |.||.|..:.|..::..
Mouse   728 RSIDRLRSEHVRKFLLTFRE----------PDLEKKYSKQVDDRFGAYVACASLVFLFICFVQIT 782

  Fly   601 TYPDILVLLGILLILLILCILAGYKKLRLQWKKLTPMSQPSCFLSRWLLRISERIEDSLFVRIPL 665
            ..|..|.:|...|...:|..|..:..:.....||.|  .|...|||.::|..   ::|..|.:..
Mouse   783 IVPHSLFMLSFYLSCFLLLALVVFVSVIYACVKLFP--TPLQTLSRKIVRSK---KNSTLVGVFT 842

  Fly   666 TMVVLLLLYVMSSQAVFSCDVAKLELSIIEAH--------------------LYNEKSYA----- 705
            ..:|.|..:|    .:|.|:...|...:.|.|                    |.:|:.:.
Mouse   843 ITLVFLSAFV----NMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQP 903

  Fly   706 ECFGPWTVTYCVVIVISLLFVVPGCPLVIKI-LAGLLILGLHLGTVHLYY--------------- 754
            .|..|...||.|  ::|||    .|.:.::| ..|.|:|.|.:..:::..
Mouse   904 NCNFPEYFTYSV--LLSLL----ACSVFLQISCIGKLVLMLAIEFIYVLIVEVPGVTLFDNADLL 962

  Fly   755 ----GFAFERSET-------TDLGLKSDYAHTWYLVALFIV-LVLRERHVNYLRKFNYFMRVCYE 807
                ...|..:.|       |.:.||   ..|..::::|:: |.|..:.|....:.::..::...
Mouse   963 VTANAIDFSNNGTSQCPEHATKVALK---VVTPIIISVFVLALYLHAQQVESTARLDFLWKLQAT 1024

  Fly   808 EAHQQTDEKLRSIKIIMANILPTHVAQVYKVR-RPHDQLYYENFSKVAVMFASIENFN------- 864
            |..::.:|.....:.::.||||..||..:..| |.:|:|||::...||||||||.||:
Mouse  1025 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE 1089

  Fly   865 ADTAG---LRILHEIICCFDDLLVDYQTRYKIEKIKVMGWTYMVACGLETDHYTDFSIDIPVKQP 926
            |:..|   ||:|:|||..||:::.:.:.| ::||||.:|.|||.|.||....|
Mouse  1090 ANNEGVECLRLLNEIIADFDEIISEDRFR-QLEKIKTIGSTYMAASGLNDSTY------------ 1141

  Fly   927 EADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNYVF 991
                                       |...:.:       :..:.:||   :::|..::|   .
Mouse  1142 ---------------------------DKAGKTH-------IKAIADFA---MKLMDQMKY---I 1166

  Fly   992 SEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKVLR 1056
            :|: :|....:|||::.|.|:|||:|..||.|||||:|||:||||.|||:.|.||||....:||.
Mouse  1167 NEH-SFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLA 1230

  Fly  1057 QFNIRCNYRGHTEVKGVGKVPTYLVVVDPDLT 1088
            ....:...||..:|||.|::.||.:...|.|:
Mouse  1231 ANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS 1262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	77/200 (39%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	66/155 (43%)
		CYCc	814..1056	CDD:214485	85/252 (34%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	84/245 (34%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	47/243 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	76/206 (37%)
		Guanylate_cyc	461..622	CDD:278633	67/163 (41%)
		DUF1053	669..761	CDD:283888	17/104 (16%)
		CYCc	1037..1238	CDD:214485	85/254 (33%)
		Guanylate_cyc	1063..1257	CDD:278633	84/247 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910