DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32305 and Adcy2

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_705762.2	Gene:	Adcy2 / 210044	MGIID:	99676	Length:	1095	Species:	Mus musculus

Alignment Length:	1153	Identity:	305/1153 - (26%)
Similarity:	511/1153 - (44%)	Gaps:	231/1153 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VILLLALVKDIILVTMVPYFAVMLFSPFIMLLSMQNNVGMITN--TLISWLMALF-LTSMDLVSD 130
            ::.||.:|....|..:..:||        :.|.::::|..:..  |.::...|:| |..::.|..
Mouse    51 IVFLLLIVMGACLALLAVFFA--------LGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFK 107

  Fly   131 LLGTIYSGAAY--------------PTVPCYDHV-----VLVSVYMTLP-------IAFYQGSSV 169
            .|..::|...:              .||..:|.|     ::..||..||       ||....||.
Mouse   108 KLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSS 172

  Fly   170 YVLGMVVSIIYIGYAFYMQYLN------DQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAI 228
            :.:  |:|:          ||:      :.:.:.:||:..|::.. ||..::...:.:..|::..
Mouse   173 HTI--VLSV----------YLSATPGAKEHLFWQILANVIIFICG-NLAGAYHKHLMELALQQTY 224

  Fly   229 LSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEP 293
            ......:...|..:...:::..||.|:||..:...::.||..|::........:......|:::.
Mouse   225 RDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKR 289

  Fly   294 YPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNY 358
            :.|||||.||:|.:|.|.:.....:||.:|::||..||..|..|..||||.|||.|.||:|:|..
Mouse   290 HTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPIS 354

  Fly   359 FPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNR 423
            .|.||..||...|:|....:.|.....:|||:|:|||||.|..|:||..|||:|:||.||.:.|.
Mouse   355 LPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANH 419

  Fly   424 LESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGE---- 484
            :|:.|:||.||:|..||..|:..|...|| :....||.|:|..::|:.|.|...:...|..
Mouse   420 MEAGGVPGRVHISSVTLEHLNGAYKVEEG-DGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRP 483

  Fly   485 ---LDDELSSASINSCRL--SYGGYYEEIQIKAQREIMKE-----VDQMAVGHCFIEWR--RSSS 537
               ||.....||:...|.  |:|.......:..:..:..|     ...:.:|....:.|  |:.|
Mouse   484 RHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKS 548

  Fly   538 MKK---QDFNE-------------EYLFSNQIHLVLGVF--RSWKREWEFHNLPDLMIKYTMLLV 584
            .||   ::.||             ::|.|..|..:...|  ::.::|:....||  ..||   .|
Mouse   549 QKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLFFYNKNIEKEYRATALP--AFKY---YV 608

  Fly   585 LCAGLAIMSINLIEEATYPDILVL---LGILLILLILCILAGYKKLRLQWKKLTPMSQPSCFLSR 646
            .||.|..:.|.:::....|...:|   .|...:.||..:...:....||..|....|      ..
Mouse   609 TCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASAS------LL 667

  Fly   647 WLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVF--------------SCDVAKLELSIIE-- 695
            |||:.|..|.:..:.||.||:|...::..|   |||              :.:.:...:|:.:
Mouse   668 WLLKSSGIIANRPWPRISLTIVTTAIILTM---AVFNMFFLSNSEETTLPTANASNANVSVPDNQ 729

  Fly   696 -AHLYNEKSYAECFGPWTVTYCVVIVISLLFVVPGCPLVIKI------------LAG--LLILGL 745
             |.|:....:   |.|:.:..|::.:||       |.:.:::            |.|  :::|..
Mouse   730 TAILHARNLF---FLPYFIYSCILGLIS-------CSVFLRVNYELKMLIMMVALVGYNIILLHT 784

  Fly   746 HLGTVHLYYGFAFER----SETTDLGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCY 806
            |...:..|....|:|    .:...:|..|       |...||.|::..|...|..:.::..:..:
Mouse   785 HAHVLDAYSQVLFQRPGIWKDLKTMGSVS-------LSIFFITLLVLGRQSEYYCRLDFLWKNKF 842

  Fly   807 EEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRR-PHDQLYYENFSKVAVMFASIENF------- 863
            ::..::.:......::::.|:||.|||:.:..|. .:::||::::..|.||||||.:|
Mouse   843 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTES 907

  Fly   864 NADTAG---LRILHEIICCFDDLLVDYQTRYK-IEKIKVMGWTYMVACGLETDHYTDFSIDIPVK 924
            :.:..|   ||:|:|||..|||||  .:.::. :||||.:|.|||.|.||..         :|
Mouse   908 DVNKEGLECLRLLNEIIADFDDLL--SKPKFSGVEKIKTIGSTYMAATGLSA---------VP-- 959

  Fly   925 QPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNY 989
                                       |.::..:|..|...:..:|  |||..|:..:..|. .:
Mouse   960 ---------------------------SQEHAQEPERQYMHIGTMV--EFAYALVGKLDAIN-KH 994

  Fly   990 VFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKV 1054
            .|:::      .|::||:||.|:|||:|..||.|||||:|||:||||.|||:||.||||..|:.:
Mouse   995 SFNDF------KLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLI 1053

  Fly  1055 LRQFNIRCNYRGHTEVKGVGKVPTYLVVVDPDLTFQDHDQVSMSMKDS 1102
            |:.....|..||...|||.|.:.||.|          :.::|.|:..|
Mouse  1054 LQTLGYTCTCRGIINVKGKGDLKTYFV----------NTEMSRSLSQS 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	81/197 (41%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	71/152 (47%)
		CYCc	814..1056	CDD:214485	85/253 (34%)
		Nucleotidyl_cyc_III	845..1081	CDD:299850	88/246 (36%)
Adcy2	NP_705762.2	AC_N	<37..264	CDD:292831	43/233 (18%)
		CYCc	240..443	CDD:214485	80/202 (40%)
		Guanylate_cyc	285..469	CDD:278633	81/184 (44%)
		DUF1053	499..603	CDD:283888	19/105 (18%)
		CYCc	852..1060	CDD:214485	86/256 (34%)
		Guanylate_cyc	882..1081	CDD:278633	89/257 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5262
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.830