Protein Alignment CG32305 and Adcy2

DIOPT Version :10

• Sequence 1: NP_728725.2
• Gene: CG32305 / 317967
• FlyBaseID: FBgn0052305
• Length: 1164
• Species: Drosophila melanogaster
• Sequence 2: NP_705762.2
• Gene: Adcy2 / 210044
• MGIID: 99676
• Length: 1095
• Species: Mus musculus
• Alignment Length: 1153
• Identity: 305/1153 - (26%)
• Similarity: 511/1153 - (44%)
• Gaps: 231/1153 - (20%)

  Fly    69 VILLLALVKDIILVTMVPYFAVMLFSPFIMLLSMQNNVGMITN--TLISWLMALF-LTSMDLVSD 130
            ::.||.:|....|..:..:||        :.|.::::|..:..  |.::...|:| |..::.|..
Mouse    51 IVFLLLIVMGACLALLAVFFA--------LGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFK 107

  Fly   131 LLGTIYSGAAY--------------PTVPCYDHV-----VLVSVYMTLP-------IAFYQGSSV 169
            .|..::|...:              .||..:|.|     ::..||..||       ||....||.
Mouse   108 KLLRVFSLVIWICLVAMGYLFMCFGGTVSAWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSS 172

  Fly   170 YVLGMVVSIIYIGYAFYMQYLN------DQVSFYLLASYAIYLFTLNLIFSFFTIIRDYGLRRAI 228
            :.:  |:|:          ||:      :.:.:.:||:..|::.. ||..::...:.:..|::..
Mouse   173 HTI--VLSV----------YLSATPGAKEHLFWQILANVIIFICG-NLAGAYHKHLMELALQQTY 224

  Fly   229 LSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQEEICSRIEDQDKNFTPSKAGLRKLFLEP 293
            ......:...|..:...:::..||.|:||..:...::.||..|::........:......|:::.
Mouse   225 RDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKR 289

  Fly   294 YPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAANRNRAMRIKFLGDSYNCVAGIPNY 358
            :.|||||.||:|.:|.|.:.....:||.:|::||..||..|..|..||||.|||.|.||:|:|..
Mouse   290 HTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPIS 354

  Fly   359 FPAHASCCVDQALEMIHITQGVSSRRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNR 423
            .|.||..||...|:|....:.|.....:|||:|:|||||.|..|:||..|||:|:||.||.:.|.
Mouse   355 LPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANH 419

  Fly   424 LESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPILQQAGIRTFLVSNRLPDAVEPGE---- 484
            :|:.|:||.||:|..||..|:..|...|| :....||.|:|..::|:.|.|...:...|..
Mouse   420 MEAGGVPGRVHISSVTLEHLNGAYKVEEG-DGEIRDPYLKQHLVKTYFVINPKGERRSPQHLFRP 483

  Fly   485 ---LDDELSSASINSCRL--SYGGYYEEIQIKAQREIMKE-----VDQMAVGHCFIEWR--RSSS 537
               ||.....||:...|.  |:|.......:..:..:..|     ...:.:|....:.|  |:.|
Mouse   484 RHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKS 548

  Fly   538 MKK---QDFNE-------------EYLFSNQIHLVLGVF--RSWKREWEFHNLPDLMIKYTMLLV 584
            .||   ::.||             ::|.|..|..:...|  ::.::|:....||  ..||   .|
Mouse   549 QKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLFFYNKNIEKEYRATALP--AFKY---YV 608

  Fly   585 LCAGLAIMSINLIEEATYPDILVL---LGILLILLILCILAGYKKLRLQWKKLTPMSQPSCFLSR 646
            .||.|..:.|.:::....|...:|   .|...:.||..:...:....||..|....|      ..
Mouse   609 TCACLIFLCIFIVQILVLPKTSILGFSFGAAFLSLIFILFVCFAGQLLQCSKKASAS------LL 667

  Fly   647 WLLRISERIEDSLFVRIPLTMVVLLLLYVMSSQAVF--------------SCDVAKLELSIIE-- 695
            |||:.|..|.:..:.||.||:|...::..|   |||              :.:.:...:|:.:
Mouse   668 WLLKSSGIIANRPWPRISLTIVTTAIILTM---AVFNMFFLSNSEETTLPTANASNANVSVPDNQ 729

  Fly   696 -AHLYNEKSYAECFGPWTVTYCVVIVISLLFVVPGCPLVIKI------------LAG--LLILGL 745
             |.|:....:   |.|:.:..|::.:||       |.:.:::            |.|  :::|..
Mouse   730 TAILHARNLF---FLPYFIYSCILGLIS-------CSVFLRVNYELKMLIMMVALVGYNIILLHT 784

  Fly   746 HLGTVHLYYGFAFER----SETTDLGLKSDYAHTWYLVALFIVLVLRERHVNYLRKFNYFMRVCY 806
            |...:..|....|:|    .:...:|..|       |...||.|::..|...|..:.::..:..:
Mouse   785 HAHVLDAYSQVLFQRPGIWKDLKTMGSVS-------LSIFFITLLVLGRQSEYYCRLDFLWKNKF 842

  Fly   807 EEAHQQTDEKLRSIKIIMANILPTHVAQVYKVRR-PHDQLYYENFSKVAVMFASIENF------- 863
            ::..::.:......::::.|:||.|||:.:..|. .:::||::::..|.||||||.:|
Mouse   843 KKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTES 907

  Fly   864 NADTAG---LRILHEIICCFDDLLVDYQTRYK-IEKIKVMGWTYMVACGLETDHYTDFSIDIPVK 924
            :.:..|   ||:|:|||..|||||  .:.::. :||||.:|.|||.|.||..         :|
Mouse   908 DVNKEGLECLRLLNEIIADFDDLL--SKPKFSGVEKIKTIGSTYMAATGLSA---------VP-- 959

  Fly   925 QPEADSEIRRGSSVLTVHFGSTEDDEMSGDNVSQPYAQVQDVAVLVMTEFALDLLRIMHDIRYNY 989
                                       |.::..:|..|...:..:|  |||..|:..:..|. .:
Mouse   960 ---------------------------SQEHAQEPERQYMHIGTMV--EFAYALVGKLDAIN-KH 994

  Fly   990 VFSEYDTFLTGSLKIGISHGSVMAGVVGLSKPHYDIWGHTVNMASRMSSTGLLDNIQVTRHTAKV 1054
            .|:::      .|::||:||.|:|||:|..||.|||||:|||:||||.|||:||.||||..|:.:
Mouse   995 SFNDF------KLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLI 1053

  Fly  1055 LRQFNIRCNYRGHTEVKGVGKVPTYLVVVDPDLTFQDHDQVSMSMKDS 1102
            |:.....|..||...|||.|.:.||.|          :.::|.|:..|
Mouse  1054 LQTLGYTCTCRGIINVKGKGDLKTYFV----------NTEMSRSLSQS 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	AcyC	62..451	CDD:441717	119/416 (29%)
		Nucleotidyl_cyc_III	292..445	CDD:448371	71/152 (47%)
		Nucleotidyl_cyc_III	845..1081	CDD:448371	88/246 (36%)
Adcy2	NP_705762.2	AcyC	54..474	CDD:441717	128/441 (29%)
		Guanylate_cyc	285..469	CDD:425528	81/184 (44%)
		Adcy_cons_dom	499..604	CDD:461877	19/106 (18%)
		Guanylate_cyc	882..1081	CDD:425528	89/257 (35%)