DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and gcy-5

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_496219.1	Gene:	gcy-5 / 191643	WormBaseID:	WBGene00001532	Length:	1122	Species:	Caenorhabditis elegans

Alignment Length:	293	Identity:	76/293 - (25%)
Similarity:	144/293 - (49%)	Gaps:	47/293 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 NLIFSFFTIIRDYGLRRAILSRYQLVYQNIVYQLVMKKENG--LLESILPRKMIRTLQEEICSRI 272
            ||:...|.::.:|      .|..::..:....:|.::|:..  ||..:||:::...|
Worm   823 NLMDHVFNMLEEY------TSTLEVDIEERTKELTLEKKKADILLSRMLPKQVAERL-------- 873

  Fly   273 EDQDKNFTPSKAGLRKLFLEP--YPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFDLAAN 335
                      |||..   :||  :..|::|.:|:|.:|.|.......|:|.:|:||:.|||....
Worm   874 ----------KAGQT---VEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDTIIE 925

  Fly   336 RNRAMRIKFLGDSYNCVAGIP--NYFPAHASCCVDQALEMIHITQG--VSSRRELDINLRIGVHS 396
            .:...:::.:||.|.||:|:|  |.: ||....||.:|:.:...:.  |.......:.||||::|
Worm   926 EHGVYKVESIGDGYLCVSGLPTKNGY-AHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGINS 989

  Fly   397 GEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHYIFREGTEAAKNDPI 461
            |...||::|.:..::.::...|:..:|:||:|.|.::|:|:...|:|.:||..:..| :::.:.|
Worm   990 GPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYET-SSRGEVI 1053

  Fly   462 LQQAGI-RTFLVSNRLPDAVEPGELDDELSSAS 493
            ::..|: .||.|.         |:.|.:..|.|
Worm  1054 IKGKGVMETFWVL---------GKTDSDTKSLS 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	59/203 (29%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	49/158 (31%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
gcy-5	NP_496219.1	PBP1_NPR_GC_like	30..440	CDD:107347
		ANF_receptor	49..426	CDD:279440
		PK_GC	546..816	CDD:270894
		HNOBA	<830..873	CDD:285003	8/48 (17%)
		CYCc	852..1042	CDD:214485	60/211 (28%)
		Guanylate_cyc	879..1067	CDD:278633	57/198 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900