DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32305 and gcy-4

DIOPT Version :9

Sequence 1:	NP_728725.2	Gene:	CG32305 / 317967	FlyBaseID:	FBgn0052305	Length:	1164	Species:	Drosophila melanogaster
Sequence 2:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans

Alignment Length:	352	Identity:	84/352 - (23%)
Similarity:	161/352 - (45%)	Gaps:	87/352 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 NLIFSFFTIIRDY--------GLRRAILSRYQLVYQNIVYQLVMKKENGLLESILPRKMIRTLQE 266
            ||:...|:::.:|        |.|...|:            |..||.:.||..:||:::...|
Worm   826 NLMDHVFSMLEEYTSSLEVEVGERTKELT------------LEKKKSDILLGRMLPKQVAERL-- 876

  Fly   267 EICSRIEDQDKNFTPSKAGLRKLFLEPYPNVSILVADMVNYTHLTTTLEAPQLVEILHDLFVNFD 331
                            ||| :.:..|.:..|::..:|:|.:|.|.:.....|:|.:|:|:|.|||
Worm   877 ----------------KAG-QAVEPESFDLVTVFFSDLVKFTDLASKCSPFQVVNLLNDVFSNFD 924

  Fly   332 LAANRNRAMRIKFLGDSYNCVAGIPNYFPAHASCCVDQALEMIHITQGVS--------------S 382
            ....::...:::.:||.:.||:|:||          ...:|.|....|:|              .
Worm   925 SIIEKHDVYKVESIGDGFLCVSGLPN----------RNGMEHIRQIVGMSLCFMEFCRNFRIPHL 979

  Fly   383 RRELDINLRIGVHSGEVFAGIIGHTKWQFDIWSKDVDITNRLESSGLPGLVHVSQRTLSMLDEHY 447
            .|| .:.||:|::||...||::|.:..::.::...|:..:|:||:|.|.::|:|:...|:|..:|
Worm   980 PRE-RVELRVGINSGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLVNNY 1043

  Fly   448 IFREGTEAAKNDPILQQAGI-RTF------LVSNRLPDAV-----EPGEL----DDELSSASINS 496
            .::..|. ::.:.|::..|: .|:      .:||:....:     :|.::    |.||::.|..|
Worm  1044 PYQFETN-SRGEVIIKGKGVMETYWLLGKMSLSNQSTPPITKVNHKPRKIASFTDSELTNYSFRS 1107

  Fly   497 C-----RLSYGGYYEEIQIKAQREIMK 518
            .     .|| ....|||:...:||:|:
Worm  1108 VSPYVENLS-DNDDEEIRRVLRREMMR 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32305	NP_728725.2	CYCc	251..449	CDD:214485	54/211 (26%)
		Nucleotidyl_cyc_III	292..445	CDD:299850	45/166 (27%)
		CYCc	814..1056	CDD:214485
		Nucleotidyl_cyc_III	845..1081	CDD:299850
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347
		ANF_receptor	49..423	CDD:279440
		PKc_like	558..819	CDD:304357
		HNOBA	<834..876	CDD:285003	11/53 (21%)
		CYCc	855..1047	CDD:214485	57/221 (26%)
		Guanylate_cyc	882..1070	CDD:278633	50/199 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900